CIBA160

Chapter 1: IntroductionSpeaker: Jukka Lobomeria, psychology student, University of Jyvaskyla.Topic: Protein synthesis's role in long-term memory.Main source: "Neurobiology of Learning and Memory" by Cerruti Rudi.

• Process starts with stimuli impacting neural pathways, leading to protein synthesis.

• Transcription: DNA replicates into mRNA.

• Translation: mRNA is translated into protein at ribosomes, aiding engram solidification.

Chapter 2: Kind Of Cascade

• Protein synthesis is vital for Long-Term Potentiation (LTP).

• High protein correlates with sustained LTP; various molecular cascades guide signal transduction.

• Protein synthesis is crucial during consolidation and maintenance phases, with actin filaments supporting neuron structure.

• Memory consolidates when resistant to interference.

Chapter 3: Local Protein Synthesis

• Neuron structure divided into LTP1, LTP2, LTP3; stimuli raise calcium levels for synthesis.

• Each compartment's position affects protein synthesis.

• Local synthesis occurs in dendritic spines during immediate stimulus responses.

Chapter 4: Local Protein Stimulus

• LTP3 stimuli prompt immediate protein synthesis for memory consolidation.

• Stronger stimuli enhance memory strength, leading to sequential protein transcription.

Chapter 5: Whole Ribosomal Complexes

• Ribosomal complexes are essential for local protein synthesis; mRNA is critical.

• The Ubiquitin Proteasome System manages protein balance to prevent overproduction.

• Different synthesis waves cater to immediate retention and specific protein needs.

Chapter 6: Kind of Receptors

• Transcription factors like CREB are crucial for mRNA synthesis and synaptic strengthening.

• Calcium acts as a signaling messenger; synthesis is self-regulated by BDNF.

Chapter 7: Kind of Evidence

• Reconsolidation has two peaks: 1-2 hours and 9-12 hours post-event.

• Immediate Early Genes like ARC help quick synthesis.

Chapter 8: Large Dendritic Spines

• Proteins interact with dendritic spines for memory consolidation.

• ARC supports spine stability, crucial for strong memory while microtubules transport mRNA and proteins for synaptic plasticity.