Week 1 topics
Biomolecules Overview
Four Major Classes of Biomolecules
- Proteins
- Carbohydrates
- Lipids
- Nucleic Acids
Monomer Units of Biomolecules
- Proteins: Amino Acids
- Carbohydrates: Simple sugars (e.g., glucose)
- Lipids: Free fatty acids, Acetyl group
- Nucleic Acids: Nucleotides (Bases, purines, and pyrimidines)
Functions of Biomolecules
- Proteins:
- Structure
- Enzymes
- Storage
- Signaling (receptors)
- Regulation
- Carbohydrates:
- Structure
- Energy storage
- Lipids:
- Energy Storage
- Cell membranes
- Signals
- Nucleic Acids:
- Information storage
- Information transfer
- Proteins:
Central Dogma of Molecular Biology
- The central dogma describes the flow of genetic information within a biological system:
- \text{DNA} \rightarrow \text{RNA} \rightarrow \text{Protein}
- Note: RNA viruses are an exception to this flow.
Metabolism
- Metabolism is defined as the creation and use of biomolecules.
- Includes both energy production and the building of cellular structures.
Gene Structure
- What makes up a gene?
- RNA Polymerase binds to the template strand.
- Nucleosomes (Histones and DNA)
- Promoter region
- TATA box
- General Transcription Factors
- Regulatory Elements
- Enhancer or Silencer