Instructor: Chris Rodell, Assistant Professor
School: Biomedical Engineering, Science & Health Systems, Drexel University
Contact: cbr58@drexel.edu
Lecture Theme: Transport in Tissues & Devices
Midterm 1 Review
Scheduled for today
Homework: HW3 to be posted by Wednesday, due in a week
Next Midterm: Future date, content focus discussed
Key Topics:
Midterm 1 Discussion
Refreshers & Generalizations
Transport in: Tissues, Tissue Engineering, Drug Delivery
Midterm 1 Review Results:
Mean Score: 66 ± 13
Median Score: 67
Interpretation: No concern, as scores are favorable and improving.
Average Score Graph: Scale from 0-100.
True/False Questions:
Based on key concepts such as equilibrium and diffusion principles
Bonus Points: Students starts with +4 on the midterm, total available score is 96.
Average scores for True/False questions: 80%
Key Points on True/False Questions:
Concentration Gradient: No flux in equilibrium
Ideal Gases: Diffusion coefficient increases with pressure
Mass Conservation Principle: Governed by GDE
Fick’s Law Application: Applicable under specific conditions only
In equilibrium, no concentration gradient → True
Diffusion coefficient increases with gas pressure → False
For dilute solutions, DAB = DBA → False
Conservation of mass via GDE under all conditions → True
Fick’s law of diffusion under limited conditions → True
Majority of biological reactions follow second order kinetics → False
Heterogeneous reactions contribute to RA → True
Diffusion is faster than convection over long distances → False
Steady State Conditions: Does not equate to zero concentration change (can have flux)
Detailed explanations of diffusion principles compared between gases, liquids, and solids
Discusses the relevance of concentration gradients in transport processes across different states of matter
General Differential Equation (GDE): Key equation for mass transport including flux and reactions
Understanding of how Fick's Law aids in predicting flux across interfaces
General use of the diffusion equation applied to biological systems and practical transport applications
Highlights mass transfer mechanisms including diffusion, convection, and their mathematical formulations
Discussion of hydrogel applications within drug delivery systems
Overview of how drugs diffuse through tissues while accounting for degradation
Examples of diffusion dynamics using steady state assumptions, boundary conditions, and concentration profiles
Detailed sketching of concentration profiles with respect to drug diffusion patterns
Understanding the relevance of concentration gradients, flux dynamics, and mass transfer rates becomes critical for successful application in biomedical contexts
Concepts from prior lectures integrated into current discussions to illustrate continuity in education and application
Emphasis on practical applications and underlying biological principles.