BMES451_Lecture 7_Transport in Tissues & Devices(1)

BMES 451 Transport Phenomena in Living Systems

  • Instructor: Chris Rodell, Assistant Professor

  • School: Biomedical Engineering, Science & Health Systems, Drexel University

  • Contact: cbr58@drexel.edu

Page 1: Overview of Course and Midterm Review

  • Lecture Theme: Transport in Tissues & Devices

  • Midterm 1 Review

    • Scheduled for today

    • Homework: HW3 to be posted by Wednesday, due in a week

    • Next Midterm: Future date, content focus discussed

    • Key Topics:

      • Midterm 1 Discussion

      • Refreshers & Generalizations

      • Transport in: Tissues, Tissue Engineering, Drug Delivery

Page 2: Midterm Statistics

  • Midterm 1 Review Results:

    • Mean Score: 66 ± 13

    • Median Score: 67

    • Interpretation: No concern, as scores are favorable and improving.

  • Average Score Graph: Scale from 0-100.

Page 3: Quiz Format and Free Points

  • True/False Questions:

    • Based on key concepts such as equilibrium and diffusion principles

  • Bonus Points: Students starts with +4 on the midterm, total available score is 96.

Page 4: Core True/False Concepts Reviewed

  • Average scores for True/False questions: 80%

  • Key Points on True/False Questions:

    • Concentration Gradient: No flux in equilibrium

    • Ideal Gases: Diffusion coefficient increases with pressure

    • Mass Conservation Principle: Governed by GDE

    • Fick’s Law Application: Applicable under specific conditions only

Page 5: Specific True/False Statements

  1. In equilibrium, no concentration gradient → True

  2. Diffusion coefficient increases with gas pressure → False

  3. For dilute solutions, DAB = DBA → False

  4. Conservation of mass via GDE under all conditions → True

  5. Fick’s law of diffusion under limited conditions → True

  6. Majority of biological reactions follow second order kinetics → False

  7. Heterogeneous reactions contribute to RA → True

  8. Diffusion is faster than convection over long distances → False

Page 6: Further Analysis of Statements

  • Steady State Conditions: Does not equate to zero concentration change (can have flux)

  • Detailed explanations of diffusion principles compared between gases, liquids, and solids

Page 7: Importance of Concentration Gradients

  • Discusses the relevance of concentration gradients in transport processes across different states of matter

Page 8: Derivation and Application of Fick’s Law

  • General Differential Equation (GDE): Key equation for mass transport including flux and reactions

  • Understanding of how Fick's Law aids in predicting flux across interfaces

Page 9: Practical Applications in Transport Systems

  • General use of the diffusion equation applied to biological systems and practical transport applications

Page 10: Mass Transfer and Diffusion Principles

  • Highlights mass transfer mechanisms including diffusion, convection, and their mathematical formulations

Page 11: Advanced Concepts in Drug Delivery Mechanisms

  • Discussion of hydrogel applications within drug delivery systems

  • Overview of how drugs diffuse through tissues while accounting for degradation

Page 12: Evaluation of Drug Delivery Scenarios

  • Examples of diffusion dynamics using steady state assumptions, boundary conditions, and concentration profiles

Page 13: Concentration Profiles and Drug Kinetics

  • Detailed sketching of concentration profiles with respect to drug diffusion patterns

Page 14: Key Takeaways

  • Understanding the relevance of concentration gradients, flux dynamics, and mass transfer rates becomes critical for successful application in biomedical contexts

Page 15: Conclusion and Recap of Course Material

  • Concepts from prior lectures integrated into current discussions to illustrate continuity in education and application

  • Emphasis on practical applications and underlying biological principles.