Chirality and Stereochemistry

Conformational Preferences and Chirality

Substituent Conformation

  • Bulky and large substituents in molecular structures prefer to occupy equatorial positions if possible. This is due to steric hindrance, as equatorial positions offer more space and minimize unfavorable interactions.

Projections and Representations

  • The Hill projection (H.I.L.L.) is a method for representing molecular structures, which typically utilizes wedges and dashed wedges to indicate three-dimensional orientation of groups.

Handedness and Chirality

  • Handedness (or chirality) refers to the property of an object or molecule that is non-superimposable on its mirror image.
  • Examples of Handedness in Everyday Objects and Systems:
    • Gas Regulators: Standard gauges for cylinders typically have right-handed threads. However, regulators for hydrogen gas specifically feature a left-handed thread, distinguishing it for safety reasons.
    • Traffic Systems: The rules governing traffic, such as the ability to make a