BS3016 Stroke II 28 Jan 2025

BS3016: Neuroscience Futures ENCHANTED BP – Explaining the Results

• Professor T G Robinson

  • Pro Vice-Chancellor

  • Head of College of Life Sciences

  • Dean of Medicine

  • NIHR Senior Investigator

Cerebrovascular Physiology: Implications for Hypertension Treatment

• Impact of Blood Pressure (BP) Management:

  • Decreasing BP:

    • Arteriolar vasodilation leading to maximal vasodilation, resulting in diminished cerebral blood flow (CBF) and potential cerebral ischaemia.

  • Increasing BP:

    • Arteriolar vasoconstriction that can lead to breakthrough vasodilation, increased CBF, but also risks blood-brain barrier (BBB) dysfunction and cerebral oedema.

Patient Criteria for Treatment

• Candidates include:

  • Patients with acute ischaemic stroke < 4.5 hours of onset eligible for intravenous rtPA (recombinant tissue plasminogen activator) with systolic BP < 185 mmHg.

  • Randomization groups established for