BS3016 Stroke II 28 Jan 2025

BS3016: Neuroscience Futures ENCHANTED BP – Explaining the Results

  • Professor T G Robinson

    • Pro Vice-Chancellor

    • Head of College of Life Sciences

    • Dean of Medicine

    • NIHR Senior Investigator

Cerebrovascular Physiology: Implications for Hypertension Treatment

  • Impact of Blood Pressure (BP) Management:

    • Decreasing BP:

      • Arteriolar vasodilation leading to maximal vasodilation, resulting in diminished cerebral blood flow (CBF) and potential cerebral ischaemia.

    • Increasing BP:

      • Arteriolar vasoconstriction that can lead to breakthrough vasodilation, increased CBF, but also risks blood-brain barrier (BBB) dysfunction and cerebral oedema.

Patient Criteria for Treatment

  • Candidates include:

    • Patients with acute ischaemic stroke < 4.5 hours of onset eligible for intravenous rtPA (recombinant tissue plasminogen activator) with systolic BP < 185 mmHg.

    • Randomization groups established for

robot