3/15/24

Proof of Chromosomal Theory of Inheritance

• At the time that DNA was discovered as the molecular basis of hereditary, there was no knowledge of DNA structure or the genetic code

Discoveries of DNA

Proof Genes are “on” the Chromosomes

• Work was done by Clavin B. Bridges

• Morgan’s experiments proved that the sex and the phenotype can be separated

  • Would give money

Discovery of the Hereditary Material

• Griffith’s experiments (1928)

• Observation: S (smooth w/ coat) and R (rough, no coat) can be inherited

• Conclusion: There is a transforming principle, a genetic material that transfirms the type R bacteria into Type S bacteria resulting in inheritance of the trait

• Conclusion: Since DNase destrotys ponly DNA, DNA is the transforming principle and molecular basis of hereditary

• Discovery of the hereditary material

• the Double helix