• increase in km → weak binding of subtrate

y int = 1/ V_max

_{so when inhibited → Vmax is smaller making 1/Vmax bigger so the whole line is shifted up}

_{km lower → so it binds tighter??}

• competitive inhbitor - inc in S can overcome the inhibitor

• noncompetitive - no amount of S can overcome inhibitor

• uncompetitive - inc in S favors inhibitor

• competitive - slope = Km/Vmax Km increases, Vmax stays same → bigger slope but y int stays the same

• noncompetitive - Km stays the same; dec in V max → bigger slope and y - int increases

• uncompetitive - more I → Km/ Vmax decreases constant so slope is the same y int. is increasing

CHRONIC MYELOID LEUKEMIA

• The BCR-ABL gene encodes a protein that is a constitutively active form of the ABL protein, a type of tyrosine kinase.

• Tyrosine kinases are enzymes that catalyze the transfer of a phosphate group from ATP to specific tyrosine residues on target proteins. This phosphorylation can lead to changes in protein function and signaling pathways.

• The BCR-ABL protein’s constitutive activity means that it is always "on," leading to uncontrolled cell division and the survival of granulocytes.