meiosis

Meiosis: Source of Genetic Variation

• Meiosis gives rise to cells that are genetically different from each other and is the type of cell division used to produce gametes (sex cells)

• During meiosis, the nucleus of the original 'parent' cell undergoes two rounds of division. These are:

  • Meiosis I

  • Meiosis II

Meiosis I

• The nucleus of the original 'parent' cell is diploid (2n) i.e. it contains two sets of chromosomes

• Before meiosis I, these chromosomes replicate

• During meiosis I, the homologous pairs of chromosomes are split up, to produce two haploid (n) nuclei

  • At this point, each chromosome still consists of two chromatids

• Note that the chromosome number halves (from 2n to n) in the first division of meiosis (meiosis I), not the second division (meiosis II)

Meiosis II

• During meiosis II, the chromatids that make up each chromosome separate to produce four haploid (n) nuclei

  • At this point, each chromosome now consists of a single chromatid

During meiosis, one diploid nucleus divides by meiosis to produce four haploid nuclei

• Having genetically different offspring can be advantageous for natural selection

• Meiosis has several mechanisms that increase the genetic diversity of gametes produced

• Both crossing over and independent assortment result in different combinations of alleles in gametes

Crossing over

• Crossing over is the process by which non-sister chromatids exchange alleles

• Process:

  • During meiosis I homologous chromosomes pair up and are in very close proximity to each other

  • The paired chromosomes are known as bivalents

  • The non-sister chromatids can cross over and get entangled

  • These crossing points are called chiasmata

  • The entanglement places stress on the DNA molecules

  • As a result of this, a section of chromatid from one chromosome may break and rejoin with the chromatid from the other chromosome

• This swapping of alleles is significant as it can result in a new combination of alleles on the two chromosomes

• There is usually at least one, if not more, chiasmata present in each bivalent during meiosis

• Crossing over is more likely to occur further down the chromosome away from the centromere

Crossing over of non-sister chromatids leads to the exchange of genetic material

Independent assortment

• Independent assortment is the production of different combinations of alleles in daughter cells due to the random alignment of homologous pairs along the equator of the spindle during meiosis I

• The different combinations of chromosomes in daughter cells increases genetic variation between gametes

• In meiosis I, homologous chromosomes pair up and are pulled towards the equator of the spindle

  • Each pair can be arranged with either chromosome on top, this is completely random

  • The orientation of one homologous pair is independent/unaffected by the orientation of any other pair

• The homologous chromosomes are then separated and pulled apart to different poles

• The combination of alleles that end up in each daughter cell depends on how the pairs of homologous chromosomes were lined up

• To work out the number of different possible chromosome combinations the formula 2ⁿ can be used, where n corresponds to the number of chromosomes in a haploid cell

• For humans, this is 2²³ which calculates as 8,324,608 different combinations

Independent assortment of homologous chromosomes leads to different genetic combinations in daughter cells