Organic Chemistry I - Chapter 5 Stereochemistry

Stereochemistry - CM 2113 Organic Chemistry I

Introduction to Stereochemistry

  • Stereochemistry is the study of the three-dimensional structure of molecules.
  • Biological systems exhibit exquisite selectivity, often discriminating between molecules that possess subtle differences in their stereochemistry. A notable example is Thalidomide, where different stereoisomers caused vastly different biological effects.
  • Constitutional isomers (also known as structural isomers) differ in their bonding sequence, meaning their atoms are connected in different ways.
  • Stereoisomers (also known as configurational isomers) possess the same bonding sequence; however, they differ in the orientation of their atoms in space.

Chirality

  • Chirality refers to the property of