Three domains of life:
Eukaryotic Cells
Prokaryotic Cells (contains Bacteria and Archaea)
Understanding differences is critical for microbiology and health-related studies.
Eukaryotes:
Single-celled eukaryotes typically lack cell walls.
Animals lack cell walls entirely.
Fungi have cell walls (made of chitin).
Algae also possess cell walls.
Prokaryotes usually have cell walls composed primarily of peptidoglycan.
Understanding interactions with drugs and other microorganisms:
Relevance in health fields, such as responses to treatments.
Utilize animal testing to predict effects on human cells due to structural similarities.
Practical benefits: Food sources (mushrooms, yeast) and antibiotics (e.g., penicillin from molds).
Organisms classified based on sexual reproduction methods and structures.
Cell walls (Fungi: chitin, Plants: glycoproteins and polysaccharides).
General Characteristics:
More complex than prokaryotic cells.
Motility present in most eukaryotic cells since they possess structures for movement (flagella, cilia).
Key Organelles and Structures:
Nucleus: Contains linear chromosomes, encased in a double membrane with nuclear pores (allowing passage in and out).
Ribosomes: Significant for protein synthesis; eukaryotes possess 80S ribosomes, while prokaryotes have 70S ribosomes.
Endoplasmic Reticulum: Rough (with ribosomes) for protein synthesis; Smooth (without ribosomes) for lipid synthesis and processing.
Golgi Apparatus: Modifies, sorts, and packages proteins for secretion or use within the cell.
Mitochondria: Energy production (ATP) through cellular respiration; has its own circular DNA.
Membrane Composition:
Both types have a plasma membrane, but eukaryotes have internal bound membranes and a more complex structure.
Genetic Material:
Eukaryotic cells contain a true nucleus; prokaryotic genetic material is located in the nucleoid region.
Structural Complexity:
Eukaryotes have membrane-bound organelles with distinct functions; prokaryotes are simpler and lack compartmentalization.
Prokaryotic Movement: Typically through flagella that rotate.
Eukaryotic Locomotion:
Flagella and cilia, where cilia can coordinate for movement.
Eukaryotic flagella wave back and forth.
Cytoskeleton: Maintains cell shape, enables motility, and transports materials.
Cell Wall Differences:
Important for identifying bacteria (gram-positive vs. gram-negative). Penicillin targets peptidoglycan in bacterial cell walls.
Understanding cell structures aids in diagnosing and treating infections, identifying tissue necrosis, and informing treatment choices.
Laboratory relevance: Tests for infection, efficacy of antibiotics, and studying structural responses to injuries.
Knowledge of prokaryotic and eukaryotic structures is critical for clinical applications, understanding human biology, and developing health-related interventions.