Quiz 2

Intoxication

• Changes in patterns of activity

• changes in syronity bewteen activites

Drug mechanisms

• Agonist spectrum

  • ligand gated ion channles

  • G-protein coupled receptors

    • enzyme activity

  • Reuptake transporter

Angoist spectrum ligandgated ion channels

• LOOOK AT SLIDE

G-protein coupled receptors

• how much of second recptor is made shows how effective it is

Angonist close receptor making it devativated

• once its inactivated it wont take more nicotine untill it’s time to smoke again (the nictine levels go down and the craving comes back)

Accumbens dopamine is also increased

• Presynaptic ach receptors in Nac dopamine realse (Nicotine)\

Steps of response

• No nicotine

• nicotine arrives

• Da neurons are activated

• Nicotine desentizes nAChR begins

Bio mechanism

• Opioids are agonists to the mu opiod receptor

  • pleasure and redusing pain

Role in addiction circut

• Mu opiod receptors are on the presynaptic

Tolerance and withdrawl (opiod)

• After a few weeks poeple can go with withdrawl when just staying at the same dose so people keep uping their dose

• Methodone treatment

  • Binds to Mu opiod recpetor but causes recpetor to be brough into cell

  • Has a long half life (24-36hrs)

  • Need to slowly increase dose

  • intercats with alchol

Caffine

• adenosine 2a recptor antaginist

• blocks the tired feeling' (prevents the inhibition of VTA dopamine)

Reuptake transport

• after vesicle release neurotramiter
  

Stimulants

• Amphetamines

  • lab manifactures

Role in the VTA

• reto messangers

• ‘

Impact on nucles accumbens

• sometimes prevents sometimes encourges