Tissues damage occurs and pain signals are created

Pain mediated chemicals =

• substances P

• Prostaglandins

• Bradykinins

• Histamine

body’s natural pain killers=

• serotonin

• enkephalins

• endorphins

Pain signals travel from peripheral → dorsal horn of spinal cord → hits gate → if conducts through → hits cerebral cortex and thalamus → brain interprets the pain → Body’s natural pain killers produced and released → binds to opioids receptors and inhibits conduction of pain impulses → decreases pain