1. Which lipoprotein is primarily responsible for transporting cholesterol from peripheral tissues to the liver?

- A) LDL

- B) VLDL

- C) HDL

- D) Chylomicrons

2. What is the major protein component of HDL?

- A) ApoB-100

- B) ApoC-II

- C) ApoA-I

- D) ApoE

3. Which lipoprotein is considered the major cholesterol carrier in the blood?

- A) HDL

- B) LDL

- C) VLDL

- D) Chylomicrons

4. What enzyme is activated by ApoA-I and is involved in the esterification of cholesterol in HDL?

- A) Lipoprotein lipase

- B) Hepatic lipase

- C) Lecithin-cholesterol acyltransferase (LCAT)

- D) Cholesteryl ester transfer protein (CETP)

5. Which lipoprotein class is rich in triacylglycerol and carries exogenous lipids from the intestine to all cells?

- A) LDL

- B) HDL

- C) VLDL

- D) Chylomicrons

6. What is the role of ApoB-100 in lipoprotein metabolism?

- A) Activates LCAT

- B) Binds to LDL receptors on cells

- C) Enhances hepatic lipase activity

- D) Transfers cholesterol esters

7. Which apolipoprotein enhances hepatic lipase activity and is primarily found in HDL?

- A) ApoA-I

- B) ApoB-48

- C) ApoA-II

- D) ApoE

8. What is the main function of VLDL?

- A) Transport cholesterol from tissues to the liver

- B) Carry dietary lipids from the intestine to cells

- C) Carry endogenous lipids from the liver to cells

- D) Store cholesterol in adipose tissue

9. Which transporter protein interacts with ApoA-1 to extract cholesterol from peripheral cells?

- A) CETP

- B) ABCA1

- C) LCAT

- D) ApoE

10. What mutation causes Tangier disease, leading to very low levels of HDL?

- A) Mutation in CETP gene

- B) Mutation in ApoA-I gene

- C) Mutation in ABCA1 gene

- D) Mutation in ApoE gene

11. Which lipoprotein class acts as a source of cholesterol esters for LDL?

- A) HDL

- B) VLDL

- C) Chylomicrons

- D) Intermediate-density lipoprotein (IDL)

12. What is the role of cholesteryl ester transfer protein (CETP) in HDL metabolism?

- A) Transfers cholesterol esters from HDL to IDL and LDL

- B) Enhances hepatic lipase activity

- C) Activates LCAT

- D) Binds to LDL receptors

13. Which lipoprotein is removed from circulation by binding to the hepatic scavenger receptor SR-B1?

- A) LDL

- B) VLDL

- C) HDL

- D) Chylomicrons

14. What are the anti-inflammatory, antioxidant, and vasodilatory effects associated with?

- A) LDL functions

- B) VLDL functions

- C) HDL functions

- D) Chylomicrons functions

15. Which apolipoprotein is exclusively found in chylomicrons?

- A) ApoB-100

- B) ApoB-48

- C) ApoA-I

- D) ApoC-II

16. What happens to LDL receptors when cholesterol concentration in cells is high?

- A) More LDL receptors are synthesized

- B) No more LDL receptors are synthesized

- C) LDL receptors increase their activity

- D) LDL receptors are degraded

17. Which lipoprotein is secreted in nascent form by hepatocytes and enterocytes?

- A) VLDL

- B) LDL

- C) HDL

- D) Chylomicrons

18. What is the function of ApoE in lipoprotein metabolism?

- A) Activates LCAT

- B) Enhances hepatic lipase activity

- C) Involved in the uptake of chylomicron remnants and VLDL by the liver

- D) Transfers cholesterol esters from HDL to IDL

19. What is the condition characterized by the inability to eliminate cholesterol from cells due to a mutation in the ABCA1 gene?

- A) Familial hypercholesterolemia

- B) Tangier disease

- C) Atherosclerosis

- D) Hypertriglyceridemia

20. Which apolipoprotein is majorly involved in the anti-oxidant function of HDL?

- A) ApoB-100

- B) ApoC-II

- C) ApoE

- D) ApoA-I

Answers :

1. C

2. C

3. B

4. C

5. D

6. B

7. C

8. C

9. B

10. C

11. D

12. A

13. C

14. C

15. B

16. B

17. C

18. C

19. B

20. D