Bioavailability: the rate at which a drug makes it to its destination and becomes available to the site of action for which it is intended
Half-Life: the amount of time it takes the body to break down and excrete one half of a drug
Time taken for the plasma concentration of the drug to decrease by 50%
Half-life is an important factor in the creation of drugs because it helps determine proper dosing intervals
Clearance is the amount of plasma from which a substance is removed per unit time
First Pass Effect: all drugs absorbed by the GI tract enter the portal blood supply, and go directly to the liver