DNA Structure and Replication Review

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RNA DNA

Monomer of DNA & RNA- nucletoides

Backbone- covalent bonds

Bases- hydrogen bonds

Leading Strand- 3’-5’

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DNA Replication-

Where?- Nucleus

Key Players- 

• Helicase

Unzips the two strands of DNA by breaking hydrogen bonds that holds DNA together

• DNA Polymerase

Replicates DNA models

• DNA Primase

Makes primase so DNA Polymerase knows where to go to start work

• Ligase

Helps glue DNA fragments together

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#1. Start at the origin. Helicase comes in and unwinds the DNA. SSBP proteins bind to the DNA stands to keep them separated. Topoisomerase keeps the DNA from supercoiling. 

#2. Primase comes in and makes RNA primers on both strands. 

#3. DNA Polymerase buils new strands.  It can only build the new strand in the 5’ prime to 3’ prime direction. The fragments that are made are Okazaki fragments

#4. Ligase seals the Okazaki fragments

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mRNA tRNA     rRNA

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