2.9 Healing

Flashcards

Q: What is the difference between resolution and repair in wound healing?
A: Resolution = near original structure/function restored; Repair = replaced with scar tissue → some functional loss.

Q: What are the 4 phases of wound healing?
A: Hemostasis, Inflammation, Proliferation, Remodelling/Maturation.

Q: What happens during hemostasis?
A: Fibrin clot forms to stop bleeding, seal wound, and provide scaffold → scab in skin.

Q: Why is inflammation necessary for healing?
A: It neutralises harmful agents, prevents further damage, and allows white blood cells to clear debris.

Q: Which cells perform wound debridement?
A: Neutrophils and macrophages.

Q: What is granulation tissue composed of?
A: Fibroblasts, collagen, new capillaries, lymphatic vessels, macrophages.

Q: What is the role of fibroblasts?
A: Produce collagen → structural support + strength.

Q: What is the role of myofibroblasts?
A: Contract wound edges → reduce replacement tissue needed.

Q: What is epithelialisation?
A: Growth of new epithelial cells that bridge and seal the wound.

Q: At what point does remodelling/maturation begin and how long can it last?
A: Begins ~2 weeks post-injury, can continue for years.

Q: What is the maximum tensile strength regained in healed tissue?
A: About 80% of the original tissue strength.