Topic | Learning Objective |
2.2.1 | Analyze a patient & develop a list of reasonable potential diagnoses. |
Annotate diagrams of mitosis to show understanding of the process. |
Identify key terms relating to the patient’s diagnosis. |
Contrast cancer cells & normal cells. Be able to identify images and slides of cancerous cells. |
Explain the reason for, and process of, performing a biopsy to a patient’s parents. |
2.2.2 | Explain the different kinds of proteins & their roles, as well as examples of each. |
Explain a patient’s diagnosis using technical terms but simplifying for the family. |
Annotate a diagram & fill in blanks to show understanding of the processes of transcription & translation. |
Practice transcription & translation, including using a codon chart properly. |
Explain what can go wrong with DNA & how it affects proteins & individuals. |
Illustrate understanding of different mutation types by showing how each could affect DNA, mRNA & amino acid chain produced. |
Analyze the sickle cell mutation. |
Explain to a patient’s family why blood is being drawn & how the process will check for genetic abnormality. |
Determine patient’s NF1 status including details of mutation, signs/symptoms of disease, what to expect in the future, care/treatments needed & related testing. |
2.2.3 | Identify key terms relating to the familial inheritance. (allele, dominant, recessive, genotype, phenotype, etc.) |
Differentiate between homozygous & heterozygous alleles, determine a patient genotype & the resulting phenotype. |
Give examples of various genotypes, alleles, and phenotypes while relating them to one another. |
Explain to a patient’s family how their child ended up with a mutated gene, as well as the likelihood that they could pass the mutation on. |
Describe the purpose of a pedigree, the symbols used, and be able to determine the inheritance patterns of certain diseases. Be able to determine genotypes and phenotypes of all family members in a pedigree. |
2.2.4 | Use patient information (like a growth chart) to determine the potential causes of disorder, eliminating possibilities until confirming a diagnosis. |
Explain how a Cytogeneticist can help the patient. |
Describe the who, what, when and why of HeLa cells. |
Describe the steps of performing a chromosome spread and be able to identify chromosomes in a microscope. |
Explain what a karyotype is, tools used to organize the chromosomes & differences in sex chromosomes. |
2.2.5 | Relate terms connected to meiosis & differentiate between a graphic showing zygote(s) & one showing gamete(s). |
Compare and contrast meiosis & mitosis. |
Label and describe the steps of meiosis I & the steps of meiosis II. Understand why the differences occur. |
Explain how many chromosomes gametes SHOULD contain after meiosis, as well as how nondisjunction could affect this number. |
Be able to label the parts of a chromosome. |
Analyze karyotypes to look for monosomy, trisomy, sex, normal chromosome #, and other chromosomal errors. |
Label & describe 5 different chromosomal errors. |
Complete a karyotype using chromosomes for a fictional patient. (ChromoBoard Activity) |
Complete a cytogenetics report based on the karyotype & the patient history. |
2.2.6 | Explain Familial Hypercholesterolemia’s cause, impacts on body & mode of inheritance. |
Summarize the process of testing for FH, and based on the genotype what is the recommended treatment plan. |
Complete a gel electrophoresis and analyze the results for FH or other genes. |
Based on electrophoresis results, create a pedigree of the Kim family members showing inheritance of FH. |
Note
Studied by 9 people