Pharmaceutics Lecture 1, 1/14/2025 (Tue)

Introduction to Class

• Topic: Pharmaceutical Dosage Forms and Drug Delivery Systems

• Focus: Non-sterile compounding

• Instructors: Your instructor and Dr. Das (co-instructor)

• Lab Start Date: February 6th

• Communication: Appointments can be made in-person or via Zoom

Course Structure

• Exams Overview:

  • Exam 1: Covers topics 1-10 (25% of final grade)

  • Exam 2: Covers topics 11-20 (25% of final grade)

  • Final Exam (Exam 3): Cumulative exam covering all topics (30% of final grade)

  • Lab Component: 20% of final grade

• Practice Quizzes:

  • Will be available every weekend after two classes for review purposes

  • Auto-graded, help to reinforce material comprehension

  • Feedback on flexibility for deadlines if students cannot complete them on weekends

Grading Breakdown

• Grading Components:

  • 80% from exams (25% each for first two exams, 30% for final)

  • 20% from lab performance

• Lab Expectations:

  • Lab grades awarded after completion of the lab

  • Importance of diligence in lab activities to secure grades

Class Expectations

• Professionalism:

  • Notify instructors in advance if unable to attend lab/exams for potential makeup

• Study Materials:

  • Emphasize reviewing syllabus and Blue Line presentations for optimal studying

  • Practice problems and quizzes are essential for exam preparedness

Exam Formats

• Exams will consist of:

  • Multiple Choice Questions

  • True/False Questions

  • Match the Following

  • Avoidance of case studies in this class

Course Content

• Topics Covered in Exams:

  • Exam 1: Up to emulsions

  • Exam 2: Following materials up to certain drug delivery advances

  • Exam 3: Polymers, nanoparticles, and advanced drug delivery systems

Understanding Pharmaceutical Ingredients

• Active Ingredients (API): Example - Ibuprofen in tablet form, responsible for therapeutic effect

• Inactive Ingredients: Non-active, provide structure, stability, and other roles in dosage forms (e.g. binders, fillers)

  • Binders: Help in mixing and maintaining unity of components

  • Disintegrants: Help tablets dissolve in the gastrointestinal tract

Dosage Forms Overview

• Role of Dosage Forms:

  • Ensure safe drug delivery, optimize therapeutic outcomes

  • Factors affecting bioavailability include: solubility, release profile, and stability of the drug

• Drug Delivery Systems:

  • Control the drug release rate (e.g., patches, sustained release)

• Examples of Drug Delivery Systems:

  • Traditional Dosage Forms: Tablets, capsules, intravenous drugs

  • Novel Delivery Systems: Transdermal patches, controlled release forms

The Importance of Formulation Design

• Key Considerations in Dosage Form Design:

  • Physical and chemical properties of drugs

  • Bioavailability and stability assessments

  • Compatibility of active and inactive ingredients

  • Route of administration based on the required therapeutic effect

Additional Considerations

• Patient Compliance: Customizing drugs for ease of administration and palatability (flavors, forms)

• Manufacturing Process: Transition from laboratory preparation to full-scale production

• Regulatory Requirements: Adherence to guidelines and documentation protocols for formulation processes

Active vs. Inactive Ingredients Examples

• Active Ingredients: Medications that provide therapeutic effects (e.g., menthol in a cough syrup)

• Inactive Ingredients: Fillers, dyes, preservatives that support the formulation but do not have a therapeutic effect (e.g., sucrose in syrups)

Conclusion

• Key Reading Materials:

  • Basic Principles and Applications to Pharmacy Practice by Dr. Das

  • Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems

• Next Class Focus: Detailed discussion on active vs. inactive ingredients and review of drug delivery systems