Drugs 101 - Mental Illness

Drugs 101 and Mental Illness

The Body as a Chemical-Based Machine

• The body operates as a chemical machine, which means that mental health issues can often arise from either physical or chemical imbalances.

Brain Function and Behavior

• The brain, being an organ, controls various human behaviors, from normal functions (like sleeping) to complex actions (like playing an instrument).
• Influences on behavior can include genetic predispositions as well as environmental factors.

Genetic Basis of Mental Illness

• Personality and mental illnesses have been shown to have a genetic component. This includes variations in personality types (Type A and B).
• Historical perspectives have seen mental illnesses attributed to nonscientific causes, such as demon possession.

Historical Treatments

• Trepanation: An ancient practice to treat mental illness by drilling holes in the skull.
• Freud's Psychotherapy (1896): Established a method to treat mental disorders through talking therapies.
• The Lobotomy (1940s) and Electroshock Therapy: Both became common treatments for severe mental illnesses, though with significant side effects.

Development of Effective Drug Treatments

• The 1950s marked the introduction of effective medications for mental health issues. Notably:
  • Schizophrenia: Defined as a loss of contact with reality, identified by symptoms such as hallucinations and delusions.
  • Thorazine (1952): First effective treatment for schizophrenia, leading to a 25% remission rate but with Parkinsonian-like side effects.

The Role of Dopamine in Schizophrenia

• High dopamine activity is theorized to contribute to schizophrenia. Thorazine acts as a dopamine antagonist to mitigate symptoms.
• Antipsychotic drugs have various effects on dopamine receptor subtypes, with D2 being particularly significant.

Evolution of Antipsychotic Drugs

• Early antipsychotics had numerous side effects due to their non-selectivity across different receptors. Newer generations, such as Atypical Antipsychotics (1972), showed fewer motor-control-related side effects and targeted serotonin receptors more effectively.

Treatment of Anxiety and Mood Disorders

• Antidepressants: Both Tricyclics and MAO Is inhibitors target serotonin to alleviate depression symptoms, with the understanding that low serotonin levels trigger depressive disorders.
• Prozac (first SSRI): Demonstrated a cleaner side effect profile but still showed side effects like anxiety and sexual dysfunction.

Treating Anxiety Disorders

• Benzodiazepines: These medications amplify GABA signaling which helps reduce anxiety. They offer cleaner profiles compared to older medications but can still lead to dependency.

Challenges in Mental Health Drug Treatment

• Many psychiatric drugs have received criticism for limited effectiveness in comparison to placebo, highlighting the complex nature of mental illnesses and patient compliance with treatment.
• Patient non-compliance is often attributed to misunderstanding the medication's purpose, fear of side effects, or even financial constraints.

Ongoing Need for Improvement

• While modern drugs have improved in terms of side effects and specificity, the efficacy rates for mental health medications may lag behind those for other diseases.
• Future breakthroughs in drug treatment will depend on advancements in understanding the biochemistry of mental illnesses, alongside patient education and addressing potential barriers to treatment adherence.