Embryonic Development of Multicellular Organisms

Introduction

  • Cell Division: large # identical cells through mitosis
  • Cell Differentiation: cells become specialized in structure & function
  • Morphogenesis: “creation of form” – organism’s shape
  • Determination: irreversible series of events that lead to cell differentiation

Totipotent vs Pluripotent vs Multipotent

  • Totipotent cells: can form all the cell types in a body, plus the extraembryonic, or placental, cells.   * Embryonic cells within the first couple of cell divisions after fertilization are the only cells that are totipotent.
  • Pluripotent cells: can give rise to all of the cell types that make up the body   * Embryonic stem cells are considered pluripotent.
  • Multipotent cells: can develop into more than one cell type, but are more limited than pluripotent cells   * Adult stem cells and cord blood stem cells are considered multipotent.

Determinants and Formation

  • Cytoplasmic determinants: maternal substances in egg distributed unevenly in early cells of embryo
  • Induction: cells triggered to differentiate
  • Cell-Cell Signals: molecules produced by one cell influences neighboring cells
  • Pattern formation: setting up the body plan (head, tail, L/R, back, front)
  • Morphogens: substances that establish an embryo’s axes
  • Homeotic genes: master control genes that control pattern formation

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