Embryonic Development of Multicellular Organisms
Introduction
- Cell Division: large # identical cells through mitosis
- Cell Differentiation: cells become specialized in structure & function
- Morphogenesis: “creation of form” – organism’s shape
- Determination: irreversible series of events that lead to cell differentiation
Totipotent vs Pluripotent vs Multipotent
- Totipotent cells: can form all the cell types in a body, plus the extraembryonic, or placental, cells. * Embryonic cells within the first couple of cell divisions after fertilization are the only cells that are totipotent.
- Pluripotent cells: can give rise to all of the cell types that make up the body * Embryonic stem cells are considered pluripotent.
- Multipotent cells: can develop into more than one cell type, but are more limited than pluripotent cells * Adult stem cells and cord blood stem cells are considered multipotent.
Determinants and Formation
- Cytoplasmic determinants: maternal substances in egg distributed unevenly in early cells of embryo
- Induction: cells triggered to differentiate
- Cell-Cell Signals: molecules produced by one cell influences neighboring cells
- Pattern formation: setting up the body plan (head, tail, L/R, back, front)
- Morphogens: substances that establish an embryo’s axes
- Homeotic genes: master control genes that control pattern formation
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