Cellular respiration is the process by which cells convert glucose into ATP, the energy currency of the cell.
Aerobic respiration occurs in the presence of oxygen and produces more ATP than anaerobic respiration, which occurs in the absence of oxygen.
Also known as the citric acid cycle
Takes place in the mitochondria
Converts pyruvate into energy (ATP)
Involves a series of chemical reactions
Produces NADH and FADH2
Generates carbon dioxide as a waste product
Essential for aerobic respiration
Can be inhibited by toxins or lack of oxygen
Named after Sir Hans Krebs, who discovered it in 1937
Involves enzymes such as citrate synthase, isocitrate dehydrogenase, and succinate dehydrogenaseglyc
Glycolysis
- Central Idea: Glycolysis is the metabolic pathway that converts glucose into pyruvate, producing ATP and NADH in the process.
Main Branches
- Energy Investment Phase
- Glucose Activation
- Fructose-1,6-bisphosphate Formation
- Cleavage of Fructose-1,6-bisphosphate
- Energy Generation Phase
- Oxidation of Glyceraldehyde-3-phosphate
- Substrate-level Phosphorylation
- Pyruvate Formation
Sub-branches
Energy Investment Phase
- Glucose Activation
- Glucose phosphorylation
- Hexokinase enzyme
- ATP consumption
- Fructose-1,6-bisphosphate Formation
- Fructose-6-phosphate to Fructose-1,6-bisphosphate
- Phosphofructokinase enzyme
- ATP consumption
- Cleavage of Fructose-1,6-bisphosphate
- Fructose-1,6-bisphosphate to 2 Glyceraldehyde-3-phosphate
- Aldolase enzyme
Energy Generation Phase
- Oxidation of Glyceraldehyde-3-phosphate
- Glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate
- Glyceraldehyde-3-phosphate dehydrogenase enzyme
- NADH production
- Substrate-level Phosphorylation
- 1,3-bisphosphoglycerate to 3-phosphoglycerate
- Phosphoglycerate kinase enzyme
- ATP production
- Pyruvate Formation
- Phosphoenolpyruvate to Pyruvate
- Pyruvate kinase enzyme
- ATP production
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