1.10 Pharmacodynamics

FLASHCARDS – Pharmacodynamics

Flashcard 1
Q: Define pharmacodynamics.
A: The study of what a drug does to the body and how it does it, focusing on its molecular targets and actions.

Flashcard 2
Q: What are the four main protein targets of drugs?
A: Carrier molecules, enzymes, ion channels, receptors.

Flashcard 3
Q: Give an example of a drug that blocks a carrier molecule.
A: SSRI (e.g., fluoxetine) blocks serotonin reuptake.

Flashcard 4
Q: What is competitive enzyme inhibition?
A: Drug binds to the enzyme’s active site, preventing substrate binding.

Flashcard 5
Q: Name two competitive enzyme inhibitors.
A: Statins, ibuprofen.

Flashcard 6
Q: What is non-competitive enzyme inhibition?
A: Drug binds to an allosteric site, changing enzyme shape so the substrate can’t bind.

Flashcard 7
Q: Give an example of a non-competitive enzyme inhibitor.
A: Aspirin inhibits prostaglandin synthesis.

Flashcard 8
Q: Why are potassium channel blockers rarely used?
A: They can cause dangerous effects in the heart and other tissues.

Flashcard 9
Q: Which sodium channel blocker is used for seizures?
A: Phenytoin.

Flashcard 10
Q: What does a β2-agonist like salbutamol do?
A: Mimics adrenaline to cause bronchodilation.

Flashcard 11
Q: What is the difference between a full and partial agonist?
A: Full agonist produces the same response as natural ligand; partial agonist produces a weaker response.

Flashcard 12
Q: What is an example of a competitive receptor antagonist?
A: Naloxone for opioid overdose.

Flashcard 13
Q: What is an example of a non-competitive receptor antagonist?
A: Cyclothiazide blocking glutamate receptors.