Exam #2 - Need to Know

[FROM PART 1]

Different types of cancer surgeries:

  1. preventative

  2. diagnostic

  3. staging

  4. curative

  5. debulking

  6. palliative

  7. supporting

  8. restorative

Might need more memorization:

What are the 3 goals for chemo?

  1. cure

  2. control

  3. palliation

What are 2 examples of chemotherapy drugs?

  1. mitotic inhibitors

  2. antimetabolites

What are 2 advantages of photodynamic therapy?

  1. can be targeted precisely

  2. costs less than other cancer treatments

Know advantages and disadvantages:

Autologous stem transplants -

Advantage: No graft v host disease

Disadvantage: these whores → cancer cells get transplanted back along with healthy stem cells too SMH

Allogenic transplants -

Advantage: donor stem calls make their own immune cells and donate stem cells

Disadvantage: there’s always dumbass risks of infections along with “graft v host disease” that bitch

Syngeneic transplants -

Advantage: the hoe “graft v host disease” can’t occur lmao

Disadvantage: this other bitch “graft v cancer” has no effect though

[FROM PART 2]

What is the time course of radiation damage?

  1. physical interactions

  2. physical-chemical interactions

  3. biological response

  4. medical effects

What are the conditions of radiation exposure?

  1. quality of radiation

  2. quantity of radiation

  3. received dose of radiation

  4. exposure conditions

What are the types of injury observed in the cell from radiation? From least to most severe

  1. subclinical

  2. mutation

  3. division delay

  4. reproductive failure

  5. interphase death

Need to know:

What are the indirect actions on the body?

  • radiation deposits energy into body tissue by energy loss effects

  • energy loss CAUSES ionization and break-up of body molecules

3 ways the “sticky” ends of chromosomes behave?

  1. breaks may rejoin = form original chromosomes

  2. they may fail to rejoin

  3. breaks reassort and rejoin = produce abnormal chromosomes

Know these:

Potentially Lethal Damage (PLD) -

  • comes from the laboratory

  • depends on post irradiation environmental conditions

  • damage may either be repaired or become lethal

Lethal Damage (LD) -

  • irreversible, irreparable damage —> cell death baby, they’re GONE

Sublethal Damage (SLD) -

  • can accumulate (if not repaired) and lead to eventual cell death

  • repairs 1-2 hours, kinda a quick bitch

  • independent of post irradiation conditions

    • EXCEPT A HOE NAMED OXYGEN