NSAIDs: Non-selective, block COX-1 and COX-2: Patient specific for drug prescriptions.
COX-1 and COX-2
COX-1: Mucosal lining in stomach, antiplatelet effects. Blocking can cause ulcers and bleeding.
COX-2: Pain, fever. Selectively blocking only Cox two we are not inhibiting platelet aggregation on COX-one. Risk for MI or history of MI, this is absolutely country in the game.
Aspirin: Has irreversible and antiplatelet effects and NSAIDs reversible.
NSAIDs Considerations
Platelet Inhibition: Stop taking aspirin one week before elective surgery because platelets live about a week.
Risk of ulcers and hypertension.
Renal-Induced Hypertension
Prostaglandins: NSAIDs block these, which are needed for mucosal lining in your stomach and to open afferent arteriole for the kidney.
Renal Induced Hypertension: Prostaglandins are needed to open your afferent arteriole of the kidney. If constricted the afferent arteriole to the kidney, we have reduced blood flow to the kidney, and the efferent aren't erial says release the renin.
Constricting the afferent arteriole leads to reduced blood flow. The efferent arteriole then releases renin, activating the RAS cascade and causing hypertension.
Celebrex: Is the only selective COX-2 inhibitor on the market. Contraindicated in patients with risk of MI or history of MI.
Toradol: Prescription-grade NSAID with a 5-day limit. Has a five day limit because because it's nephrotoxic.
Opioids
Bind to mu receptors.
No ceiling dose; the maximum dose is limited by adverse effects (respiratory depression).
Start low and go slow, especially with the elderly.
Opioid Naive vs. Opioid Tolerant
Opioid naive: Someone who does not take opioids regularly, requiring lower doses.
Opioid tolerant: Someone who uses drugs recreationally or for chronic pain management, requiring higher doses.
Important to get a good patient history.
Opioid Conversions
Math is involved with math.
Ten milligram IV MORPHINE = 30 milligrams P O.
Make sure when ordering meds and switching between them they are correct
Conversion chart is used to convert between IV and PO doses; it hangs in every med room.
Methadone
It is used to come some people off of drugs. Great. Specifically heroin. Yes. This is the drug. Methadone is used for getting people off heroin, and it's just as addictive as heroin
Patient-Controlled Analgesia (PCA)
The patient must be cognitively intact.
Patient controlled: the patient must push the button themselves.
Demand rate: Bolus dose when the patient pushes the button (e.g., demand rate push button, 0.2 mg with 20-minute lockout).
Can be administered at a nasal route.
Chart demands and amount administered to know if medication is working.
Interspinal Analgesia
Epidurals: Most common in labor and delivery.
Placement by anesthesiologist, management by anesthesiologist.
Intermittent or continuous boluses.
Adverse effects
Narcan: Blocks opioids.
Opioids: Have a longer half life than narcan, give another dose or a consistent drip.
Lots of other adjuvants used for pain.
Cannabis: Not given on the hospital.
Ketamine: a hallucigetic that actually does not relieve any pain but just acts as a hallucinogen.
Education is Important
Explain why drugs are being given and how to report changes.
Train people to be able to use these scales.
Teach people they're not gonna become addicts.
Make sure to take pain meds: " You're not impressing me, sir Graham."
Identify acceptable functional level of pain.
We want to identify how they want to measure levels of pain.