Module Overview - Focus on Cancer, Endocrine, and HIV.

Cancer Overview - Definition: Group of diseases with uncontrolled cell growth.

Biology of Cancer
  • Dysfunctions in cancer development:
    • Defective Cell Proliferation:
    • Loss of apoptosis, uncontrolled division leading to increasing cell numbers.
    • Defective Cell Differentiation:
    • Cells only perform specific functions loss.
Mutations in Genes
  • Protooncogenes: Promote regular cell growth; mutations turn them into oncogenes (tumor-inducing).
  • Tumor Suppressor Genes: Suppress growth; mutations can lead to inactivity (e.g., BRCA1, BRCA2).
Stages of Cancer Development
  1. Initiation: Irreversible mutation occurs, leading to loss of cellular regulation.
  2. Promotion: Reversible growth of altered cells occurs (ex: dietary factors).
  3. Progression: Increased tumor growth, invasiveness, and metastasis.
Carcinogens
  • Types:
    • Chemical: (ex: benzene, formaldehyde)
    • Radiation: UV rays linked to skin cancer.
    • Viral: Certain viruses cause malignancies (e.g. HPV, Hepatitis B).
Immune System Role
  • Immunologic Surveillance: The immune response to tumor antigens.
  • Immunologic Escape: Cancer cells evade immune detection.
Tumor Markers
  • Used to monitor therapies and recurrence (e.g., PSA, CA-125).
Benign vs. Malignant Tumors
  • Benign: Encapsulated, well-differentiated, low recurrence.
  • Malignant: Invasive, poorly differentiated, metastatic.
Cancer Classification
  • Types: Histologic, Clinical Staging, TNM classification.
    • TNM Parameters:
    • T: Tumor size/invasiveness.
    • N: Lymph node involvement.
    • M: Metastasis status.
Warning Signs of Cancer
  1. Change in bowel/bladder habit.
  2. Sore that doesn’t heal.
  3. Unusual bleeding.
  4. Thickening/lump.
  5. Indigestion.
  6. Change in warts/moles.
  7. Nagging cough.
Cancer Treatment Education and Precautions
  • Patient Education:
    • Managing Side Effects: Educate on common side effects (e.g., nausea, fatigue, hair loss, neuropathy) and strategies for management (e.g., antiemetics, rest, skin care).
    • Adherence to Treatment: Emphasize the importance of following chemotherapy, radiation, or immunotherapy schedules strictly for optimal outcomes.
    • Infection Prevention: Advise on hand hygiene, avoiding crowds, reporting fever immediately due to immunosuppression from treatment.
    • Nutrition and Hydration: Recommend maintaining a balanced diet and adequate fluid intake to support healing and manage side effects.
    • When to Seek Help: Instruct on urgent signs/symptoms requiring immediate medical attention (e.g., high fever, uncontrolled pain, severe bleeding).
  • Nurse Precautions:
    • Safe Handling of Chemotherapeutic Agents: Adhere to institution-specific guidelines for preparing, administering, and disposing of hazardous drugs, including proper PPE (double gloving, impermeable gowns, face shields).
    • Neutropenic Precautions: Implement strict infection control measures for immunocompromised patients (e.g., hand hygiene, private rooms, limiting visitors, avoiding fresh fruits/vegetables, monitoring for signs of infection).
    • Monitoring for Adverse Reactions: Closely monitor patients during and after administration of chemotherapy/immunotherapy for acute and delayed adverse reactions (e.g., extravasation, hypersensitivity, anaphylaxis).
    • Psychosocial Support: Provide emotional support and resources for patients and families coping with a cancer diagnosis and treatment.
    • Pain Management: Assess and manage cancer-related pain effectively using pharmacological and non-pharmacological interventions.

Endocrine Overview

Diabetes Mellitus (DM)
  • Type 1 DM: Autoimmune destruction of beta cells, requiring exogenous insulin.
    • Symptoms include polydipsia, polyuria, polyphagia.
  • Type 2 DM: Insulin resistance with inadequate secretion; linked to obesity, genetics.
    • Symptoms include fatigue, recurrent infections.
Diabetes Diagnostics
  • Normal Glucose Range: 74 to 106 mg/dL.
  • Diagnostic Methods: A1C, fasting glucose levels, oral glucose tolerance test.
Complications of Diabetes
  • Diabetic Foot Care: Risk of neuropathy and poor healing, leading to ulcers and infections.
  • Common Complications: Retinopathy, nephropathy, neuropathy.
Diabetes Education and Precautions
  • Patient Education:
    • Blood Glucose Monitoring: Instruct on proper use of glucometers, frequency of testing, and target ranges. Emphasize logging results.
    • Medication Administration: Teach proper insulin injection technique (site rotation, dose accuracy) or oral medication regimen, including timing and potential side effects.
    • Dietary Management: Education on carbohydrate counting, balanced meals, portion control, and avoiding sugary drinks.
    • Exercise: Advise on the benefits of regular physical activity and precautions (e.g., checking blood sugar before/after, carrying snacks).
    • Foot Care: Emphasize daily foot inspection, proper footwear, avoiding walking barefoot, and prompt reporting of any sores or injuries.
    • Sick Day Rules: Provide instructions for managing diabetes during illness (e.g., frequent monitoring, adequate hydration, adjusting medication as advised by provider).
    • Hypoglycemia Management: Educate on recognizing symptoms of low blood sugar and immediate treatment (e.g., 15-15 rule).
  • Nurse Precautions:
    • Medication Safety: Verify insulin doses with another nurse, ensure correct type of insulin, and proper administration route (e.g., subcutaneous).
    • Monitoring for Complications: Assess for signs of chronic complications (retinopathy, nephropathy, neuropathy) during hospital stays.
    • Hypoglycemia/Hyperglycemia Management: Be prepared to treat acute episodes, ensuring readily available glucose sources and monitoring response. Administer IV insulin as per protocol for severe hyperglycemia/DKA/HHS.
    • Patient Safety: Ensure patients with neuropathy are aware of fall risks and have appropriate foot protection.
Hyperthyroidism
  • Definition: Overproduction of thyroid hormones (T<em>3T<em>3 and T</em>4T</em>4) by the thyroid gland, leading to increased metabolic rate.
  • Causes: Most commonly Graves' disease (autoimmune).
  • Symptoms: Weight loss, nervousness, heat intolerance, tremors, palpitations, exophthalmos (in Graves' disease), goiter.
  • Treatment: Antithyroid medications (e.g., methimazole, propylthiouracil), radioactive iodine therapy, surgery (thyroidectomy).
Hyperthyroidism Education and Precautions
  • Patient Education:
    • Medication Adherence: Stress the importance of taking antithyroid medications exactly as prescribed and not discontinuing them abruptly.
    • Monitoring for Side Effects: Educate on signs of potential adverse effects (e.g., agranulocytosis with antithyroid drugs - sore throat, fever).
    • Symptoms to Report: Advise immediate reporting of worsening symptoms, especially signs of thyroid storm (fever, severe tachycardia, altered mental status).
    • Dietary Considerations: Avoid iodine-rich foods if contraindicated by treatment plan.
    • Eye Care: For Graves' ophthalmopathy, advise on lubricating eye drops and protecting eyes from irritants.
  • Nurse Precautions:
    • Thyroid Storm Recognition: Closely monitor for signs of thyroid storm (fever, extreme tachycardia, delirium) and be prepared for emergency management.
    • Cardiac Monitoring: Monitor heart rate and rhythm due to increased risk of arrhythmias.
    • Comfort Measures: Provide a cool, quiet environment to help manage heat intolerance and nervousness.
    • Medication Administration: Administer antithyroid medications as ordered and monitor for therapeutic effects and side effects.
Hypothyroidism
  • Definition: Underproduction of thyroid hormones (T<em>3T<em>3 and T</em>4T</em>4) by the thyroid gland, leading to a slowed metabolic rate.
  • Causes: Hashimoto's thyroiditis (autoimmune), iodine deficiency, thyroidectomy, radiation therapy.
  • Symptoms: Weight gain, fatigue, cold intolerance, bradycardia, constipation, dry skin, hair loss, muscle aches, depression.
  • Treatment: Thyroid hormone replacement therapy, primarily levothyroxine.
Hypothyroidism Education and Precautions
  • Patient Education:
    • Daily Medication Adherence: Emphasize taking levothyroxine consistently, typically on an empty stomach with water, 30-60 minutes before food/other medications.
    • Lifelong Treatment: Explain that thyroid hormone replacement is usually lifelong.
    • Symptoms of Imbalance: Educate on signs of over- or under-medication (hyperthyroid symptoms if dose too high, hypothyroid symptoms if dose too low) and the need for regular blood tests to adjust dosage.
    • Drug Interactions: Advise about potential interactions with other medications (e.g., iron, calcium, antacids, proton pump inhibitors) that can impair absorption.
    • Constipation Management: Suggest increased fiber intake and fluids.
  • Nurse Precautions:
    • Myxedema Coma Recognition: Monitor for and be prepared to manage myxedema coma (severe hypotension, hypothermia, hypoventilation, altered mental status) in critical situations.
    • Medication Timing: Administer levothyroxine consistently, accounting for food and other medication interactions.
    • Cardiac Monitoring: Monitor for bradycardia and other cardiac changes, as patients may have underlying cardiovascular disease.
    • Warming Measures: Provide a warm environment to help manage cold intolerance.
    • Preventing Drug Interactions: Be aware of medications that can affect levothyroxine absorption or metabolism.

HIV Overview

  • Definition: RNA virus causing immunosuppression; transmitted through body fluids.
Transmission
  • Not spread through casual contact; mainly through sexual contact with an infected individual.
Disease Progression
  • Stages:
    • Acute stage: Flu-like symptoms, CD4 counts drop.
    • Chronic stage: Often asymptomatic.
    • AIDS: CD4 count <200 cells/μL\mu L or presence of AIDS-defining illness in an HIV-positive individual.
Diagnostics
  • CD4 Count & Viral Load: Reflect immune function and disease activity.
  • Testing Methods: Rapid HIV tests and confirmatory tests.
Treatment Overview
  • Goal: Suppress viral load, prevent progression to AIDS.
  • ART Classes: NRTIs, protease inhibitors, integrase inhibitors.
Risk Reduction and Education
Patient Education
  • Importance of strict medication adherence to achieve viral suppression, prevent drug resistance, and improve quality of life.
  • Safe practices to prevent infection transmission: consistent and correct condom use, avoiding sharing needles/syringes, and understanding mother-to-child transmission prevention.
  • Regular follow-up appointments for monitoring CD4 count and viral load, and for overall health assessments.
  • Nutritional guidance, maintaining a healthy lifestyle, and avoiding opportunistic infections through vaccinations and prophylaxis.
  • Importance of disclosing HIV status to sexual partners and healthcare providers to ensure safe practices and proper care.
  • Accessing mental health support and resources for coping with the diagnosis and managing chronic illness.
Nurse Precautions
  • Adherence to standard precautions (universal precautions) for all patient encounters, regardless of known HIV status, including hand hygiene and safe injection practices.
  • Proper use of Personal Protective Equipment (PPE) such as gloves, gowns, masks, and eye protection when anticipating exposure to blood or body fluids.
  • Strict needle stick and sharps injury prevention protocols, including safe handling and disposal of needles and other sharp instruments in puncture-resistant containers.
  • Prompt reporting of any occupational exposures (e.g., needle stick) and initiation of Post-Exposure Prophylaxis (PEP) within 72 hours if indicated, following institutional guidelines.
  • Maintaining patient confidentiality regarding HIV status and all health information, adhering to HIPAA