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M1.1 Basic Terminology

  • Anatomy: Study of body structure.

    • Microscopic Anatomy: Structures observed with a microscope.

    • Macroscopic Anatomy (Gross): Structures visible to the naked eye.

  • Physiology: Study of body functions and how body parts work together.

    • Key concept: Homeostasis.

    • Animal Physiology: Study in animals.

    • Comparative Physiology: Study across species.

  • Systemic Approach: Study of structures and functions within an organ system (e.g., nervous system).

  • Principle of Complementarity: Function reflects structure; form determines function.

Anatomical Position

  • Standardized frame of reference for anatomical descriptions: subject faces observer, palms forward.

  • Key terms:

    • Prone: face down.

    • Supine: face up.

  • Body Planes: described as:

    1. Sagittal Plane: divides into right and left sections.

    2. Frontal (Coronal) Plane: divides into anterior and posterior sections.

    3. Transverse Plane: divides into upper and lower sections.

Major Directional Terms

  • Superior/Inferior: Up/Down.

  • Anterior/Posterior: Front/Back.

  • Proximal/Distal: Near/Far from attachment.

  • Medial/Lateral: Close/Far from midline.

  • Superficial/Deep: Close/Far from surface.

Levels of Organization

  • Levels from simplest to most complex:

    1. Chemical: Atoms and molecules.

    2. Cellular: Cells.

    3. Tissue: Groups of similar cells.

    4. Organ: Different tissues forming a structure (e.g., brain).

    5. Organ System: Groups of organs (e.g., nervous system).

    6. Organism: Living entity made up of organ systems.

M1.3 Homeostatic Mechanisms

  • Homeostasis: The intricate processes responsible for maintaining a stable internal environment, regardless of external fluctuations.

  • Stress: Refers to any condition or factor that poses a challenge to homeostasis, invoking physiological responses.

  • Components involved in homeostatic regulation:

    • Receptors: Detect changes in the environment and send signals to control centers.

    • Control Centers: Analyze information and determine the necessary response to maintain homeostasis.

    • Effectors: Execute the responses through muscle contractions or glandular secretion to restore balance.


Feedback Mechanisms

  • Negative Feedback: Reverses deviation from set point; common for maintaining homeostasis (e.g., temperature regulation).

  • Positive Feedback: Amplifies change, leads to rapid alterations in body state (e.g., childbirth).

M2.1 Atoms and Molecules

  • Matter: Composed of elements, has mass and volume.

  • Atom: Smallest part of an element; nucleus contains protons and neutrons; electrons orbit nucleus.

  • Atomic properties: Atomic number (protons), Mass number (protons + neutrons).

  • Ions: Charged atoms; cations (positive), anions (negative).

  • Isotopes: Variants of elements with different neutron counts.

Chemical Bonds

  • Types: Ionic, Covalent, Hydrogen Bonds.

  • Ionic Bonds: Formed by attraction of opposite charges.

  • Covalent Bonds: Electrons shared between atoms; can be single, double, or triple.

  • Hydrogen Bonds: Weak attractions between polar molecules (important in water).

M2.2 Inorganic Compounds

  • Water (H₂O): Constitutes approximately 70% of cellular composition, is essential for life, serving crucial functions such as:

    • Acting as a solvent for biochemical reactions.

    • Regulating temperature through high heat capacity.

    • Facilitating chemical reactivity in metabolic processes.

    • Providing lubrication in joint and body cavity functions.

  • Acids/Bases: Substances that can donate protons (acids) or accept protons (bases), significantly influencing the characteristics and behavior of solutions.

  • pH Scale: A logarithmic scale ranging from 0 to 14 that quantifies the acidity or alkalinity of solutions, critical for maintaining proper biological functions.


M2.3 Organic Compounds

  • Macromolecules: Large organic compounds made of repeating subunits (monomers).

    • Carbohydrates: Monosaccharides (simple sugars), disaccharides (two sugars), polysaccharides (many sugars).

    • Proteins: Composed of amino acids, exhibit various functions (structural, communication, protection).

    • Levels of Protein Structure: Comprises four levels: Primary (sequence of amino acids), Secondary (alpha helices and beta sheets), Tertiary (three-dimensional structure), and Quaternary (multiple polypeptide chains).

    • Enzymes: Catalysts for metabolic reactions.

    • Lipids: Energy storage, structural (phospholipids, steroids).

    • Nucleic Acids: DNA and RNA, store genetic information.

M3.1 Intracellular Organization

  • Cell: Basic unit of life containing a plasma membrane and cytoplasm with organelles.

  • Membranes: Selectively permeable, composed of phospholipids and proteins forming the fluid mosaic model.

M3.2 Cell Cycle

  • Chromatin/Chromosome: DNA forms chromatin within the nucleus and condenses into chromosomes during cell division.

  • Cell Cycle Phases: Interphase (growth, DNA replication) and Mitosis (cell division).

M3.3 Membrane Transport Mechanisms

  • Passive Transport: No energy required (e.g., diffusion, facilitated diffusion, osmosis).

  • Active Transport: Energy required for movement against the concentration gradient (e.g., sodium-potassium pump).

  • Tonicity: Effects of solutions on cell volume; isotonic, hypotonic, hypertonic.

M4.1 Histology and Cell Junctions

Tissues: Groups of similar cells performing functions; classified as epithelial, connective, muscle, and nervous.

  • Epithelial Tissue: Covers body surfaces and lines cavities; essential for protection, absorption, and secretion.

  • Connective Tissue: Provides support and structure to the body, characterized by a variety of cell types and an extracellular matrix.

  • Muscle Tissue: Responsible for movement through contraction; encompasses three types: skeletal, cardiac, and smooth muscle.

  • Nervous Tissue: Composed of neurons and glial cells, critical for transmitting signals throughout the body.

  • Intercellular Junctions:

  • Tight junctions, desmosomes, gap junctions for cell interaction.


M4.2 Glandular Epithelium

Glands: Synthesizing and secreting substances; classified as endocrine (ductless) and exocrine (with ducts).

  • Endocrine Glands: Ductless glands releasing hormones directly into the bloodstream, regulating various bodily functions.

  • Exocrine Glands: Glands with ducts that secrete substances onto epithelial surfaces or into body cavities, facilitating functions like digestion and secretion of sweat.

  • Methods of Secretion:

  • Merocrine: Release products through exocytosis without loss of cellular material.

  • Apocrine: Involve the loss of part of the cell's cytoplasm along with the secretory product.

  • Holocrine: Entire cells rupture to release their contents, as seen in sebaceous glands.

M4.3 Epithelial Tissue Classification

  • Epithelial tissues are classified based on layers and cell shape:

    • By layers: Simple (one layer) vs. Stratified (multiple layers).

    • By shape: Squamous (flat), Cuboidal (cube-shaped), Columnar (tall and column-like).

  • Microscopic Anatomy: Different types of epithelium serve various functions in protection, absorption, secretion.