Neural Communication, Neuroplasticity, and Brain Damage

Neurotransmitters

  • Different types of neurotransmitters exist, with endorphins being a popular category.
  • Endorphins are commonly referred to as morphine within, focusing on pain control and pleasure/rewarding behavior.
  • Neurotransmitters affect brain processes like emotions and stability.
  • Charts in textbooks and notes provide information on various neurotransmitters.
  • The focus is on neurotransmitters that occur naturally in the brain and body.

Key Neurotransmitters and Their Functions

  • Acetylcholine: Memory, attention
  • Dopamine & Serotonin: Pleasure, arousal, reward
  • Norepinephrine & Acetylcholine: Alertness (on switches)
  • GABA: Downer, turns things off
  • Glutamate: Memory
  • Endorphins: Pain and pleasure

Agonists and Antagonists

  • Agonists: Increase the effect of neurotransmitters by mimicking receptor sites or making it easier for neurotransmitters to get in. They can mimic or block reuptake production.
  • Antagonists: Block or inhibit neurotransmitters by blocking the receptor sites or stopping the reuptake process. They prevent neurons from releasing neurotransmitters, prolonging their effect.

How Drugs Work

  • Drugs work by targeting receptor sites.
  • Agonists mimic neurotransmitters, creating more of a sensation or making it easier for neurotransmitters to enter neurons.
  • Antagonists block neurotransmitters or stop the reuptake process.
  • Reuptake inhibitors prevent neurons from releasing neurotransmitters, prolonging their effect.

Painkillers

  • Two main types of painkillers: Acetaminophen and Ibuprofen.
  • Acetaminophen (e.g., Tylenol) reduces pain and fevers.
  • Ibuprofen (e.g., Advil) reduces pain and inflammation.
  • It's important to know which type to take depending on the issue.
  • Tolerance for painkillers can develop with continued use, leading to addiction.

The Endocrine System

  • The endocrine system involves hormones, which function similarly to neurotransmitters but affect organs instead of the brain.
  • Hormones work slower than neurotransmitters.
  • Hormones are created by endocrine glands and travel through the bloodstream.
  • Some hormones are identical to neurotransmitters but take different routes.
  • The adrenal and pituitary glands are important for hormone production within the autonomic nervous system.

Biopsychosocial Approach

  • Biopsych involves biological factors, behavioral science, neuroscience, behavior genetics, and physiology.
  • Psychology cannot be divorced from biology; they work together.
  • The modern biopsychosocial approach integrates biological, psychological, and social factors.
  • Brains are roughly the same size from person to person, though larger now than in cavemen.
  • Each sub system must be integrated.

Neuroplasticity

  • Neuroplasticity is the brain's ability to change and adapt.
  • It is easier and faster in children, but adults can also reorganize and build new pathways.
  • The brain is always changing and building new pathways as you learn.
  • Neuroplasticity is what sets humans apart from animals, allowing for faster adaptation.
  • The more you practice, the more you develop pathways

Lesions

  • Lesions refer to tissue destruction, often in the brain in the context of psychology.
  • The brain still wants to rewire after lesions, especially in childhood.

Brain Imaging Systems

  • Different imaging systems are specialized for different things.
  • EEG (Electroencephalogram): Reads activity as it goes through the brain, showing where neurons are active.
  • MEG (Magnetoencephalography): Looks at magnetic fields from brain's neural activity.
  • CT Scan (Computed Tomography): Takes x-rays from different angles to build an image of the brain.
  • PET Scan (Positron Emission Tomography): Tracks activity by tracking glucose with a dye, showing where activity is happening.
  • MRI (Magnetic Resonance Imaging): Uses radio waves to create a computer model of soft tissue.
  • fMRI (functional MRI): Looks at natural blood flow to show brain activity and structural abnormalities.

Neurogenesis

  • Neurogenesis is the ability to form new neurons as the brain learns and adapts.
  • The brain has a limited ability to repair itself; it can rewire but not fully repair.
  • Younger brains can reorganize more easily.
  • Severely injured areas of the spine and brain cannot regenerate.

Split Brain Research

  • The corpus callosum connects the left and right hemispheres, enabling communication.
  • Split brain surgery separates the hemispheres, often to treat severe epilepsy.
  • Cutting the corpus callosum doesn't affect personality because the lobes are still intact.
  • The two sides of the brain are close together but not fused; the corpus callosum keeps them connected.
Split Brain Experiments
  • In experiments, split-brain patients focus on a dot with words on either side. Normal brains perceive "heart," but split brains see "he" and "art" separately.
  • Verbal responses come from the left side (e.g., saying "art"), while motor responses come from the right side (e.g., pointing to "he").
  • The right side of the brain controls the left side of the body, specializing in facial recognition and spatial awareness.
  • The left side of the brain controls the right side of the body, specializing in logic, math, and spatial reasoning.
  • Each hemisphere has control of the opposite side of the body.
  • Right side: facial recognition, spatial awareness, self-awareness.
  • Left side: logical, mathematical, spatial reasoning.