health sci 1111

Pseudoscience and Self-Help

Scientific evidence is often screwed by social media, not backed by facts, which affects decision-making. Pseudoscience is the spread of misinformation and word of mouth. We must stay away and move closer to fact-based scientific evidence. 


  • Dunning Kruger Effect -> the less you know = overestimate their ability, ignorance


Misinformation can lead to disease and infection; anti-vax are led by personal beliefs and misinformation, most definitely not by science. 



Early Life Inputs 

Epigenetic Patterns-> genome flexibility, beyond fixed DNA code, can affect gene expression and carried within gametes

-Early life stressors form the person you become, neglect, trauma, illness, loss, poverty, etc


The importance of early development = shapes mental wellbeing


Critical Window                                        vs.                                        Sensitive Window

crucial for normal development, not extremely detrimental 


Prenatal= exposure to trauma


Infant emotional attachment= children and primary caregivers 


People who were small at birth have an increased risk of developing, e.g. coronary heart disease (CHD) and type 2 diabetes later in life. Not only a small body size at birth but also non-optimal growth during infancy is associated with an increased risk for the disease above.


CHD- Coronary heart disease, more likely to develop if small at birth


Dutch Hunger Winter Study

Effects of maternal undernutrition during the Dutch famine in 1944-45. Gestation with a focus on chronic cardiovascular and metabolic diseases, aging and mental health. 



ACE study-> How childhood trauma shapes the person and mental welfare. The study also emphasizes the importance of early intervention and support to prevent the long-term impacts of ACEs. It has since influenced public health policy and trauma-informed care approaches aimed at helping people with histories of childhood adversity.

  • Childhood trauma impacts the way we respond to stress- it could be different than others.


Toxic Stress-> Prolonged stress during critical or sensitive windows, long-term severe effects- get sick often, physical effects


Helsinki Birth Cohort-> 20% more likely to be depressed at follow, intergenerational effects among women


Gene Regulation->Cell identity- exposure to the environment

Imprinting - sex differences depending on who they are inherited from


Early Life stressors can have long-term and potentially intergenerational impacts on health and well-being. Through intervention, we can tackle this!!





Mental Health and Mindset

Fixed mindset

  • Not open to things changing or other perspectives, stuck in your ways, unable to believe that something could be different

  • Restricts many efforts and attempts 

  • View their ability as fixed


Growth mindset

  • It allows for new opportunities and success because you can view things from many different perspectives and are open to seeing things from others’ sides, a growth mindset is so beneficial and leads to a well-rounded and open mindset. 

  • Approach as “okay, i don't understand” or “I’m not very good at this” later turns into, “Even though i am not very good at this, i am going to try one more time.” 

  • A growth mindset is not just EFFORT; must be good strategy and support in said process

  • PROBLEM SOLVING !!!!


CAROL DWECK -> Examined praise and person to person feedback, and its impact on childhood development. 



How everyday interactions shape mindsets->

-The language we use tells others what we believe and what we value

-Feedback tells us what is expected of us and what goals we should have


Many Factors that contribute to potentially developing a mental disorder,

Adolescent- relationships 

Early Life stressors

Exposure to others

Substance abuse

Sexual behaviors

Some of the examples above can lead to other ones, 


Multifactorial Causation

  • Combination of many factors that lead to disorders

  • Social and environmental factors

  • Must think about all factors prior to intervening 


Interventions include these three stages

  • Prevention

  • Promotion

  • Treatment


Why do some people avoid challenges, while others seek it out?


Praise = acknowledging the fact there can be change, influences students' response to failure. 


     Neuroplasticity 

The brain's ability to adapt

Strengthening or weakening our neurons and their pathways


Used to believe that the brain only developed in childhood and then declined later in life- predicated on brain damage patients would rarely make a recovery, inability to observe the inner workings of the brain, the brain was seen as a machine. 


Neurogenesis -> Birth of new neurons and glial cells


Plasticity-> New neural connections, 

                     Use it or lose it 

                     Use it and improve it

                     Time

                     Salience

                     Age

                     Repetition 


Impacts on brain development;

  • Learning environments impact brain development 

  • Psychoactive drugs can impact brain development

  • Early stress & Parent child relationships also contribute 

  • Peer relationships 

  • Physical Development 

  • Intestinal Flora- linked to brain 


Neuroplasticity can also be maladaptive, chronic pain, PTSD


Phantom Limbs-> Limb that has been amputated; still feel pain in said limb

Difficulty getting relief from pain 

Phenomenon described by neuroplasticity 


Meditation and Neuroplasticity 

  • Keep our brains young = meditation 



 Resilience 

Overcoming negative effects of risk exposure adapting or coping successfully with traumatic experiences 


  1. Content Specific

  2. Culture Specific  


PROMOTIVE AND PROTECTIVE FACTORS AND PROCESSES


Promotive Factors- characteristics, conditions or resources that enhance positive development          eg. access to quality education


Promotive Process- actions, behaviors and strategies that are engaged in to promote positive outcomes    eg. commitment to studying and learning

Protective Factors- Shield or buffer against the development of negative outcomes or risks         eg. strong social support 


Protective Process- actions, behaviors, or strategies that individuals or communities use to reduce or mitigate the impact of adverse situations or stressors

eg.    seeking help during difficult times


Promotive = predictors of higher levels of better outcomes

Protective = compensate for risks, predictors of lower level of psychological symptoms 


Assets = reside within an individual , coping skills, competance 

Resources = emotional supports , parental support 


Categories of resilience models  


  • Compensatory…..

Where a resilience factor counteracts a risk factor

Has direct effect on outcome

Decreasing the possibility of a negative outcome

Independent of the effect of the risk factor 

eg.mindfulness


  • Protective….

Assets and resources lower the risk of a negative outcome

Protective factors may neutralize the effects of risks, weaken, but not

completely remove them, or enhance the positive effect of another

promotive factor in producing a positive outcome

Protective Stabilizing= More risk more negative outcome


  • Challenge….

Exposures to both low and high levels of a risk factor are associated

with negative outcomes, but moderate levels of the risk are related to

less negative (or positive) outcomes.


  • Inoculation….

 A little bit of challenge so that you know how to deal with it 


Intervention to Cultivate Resilience  

Goal of intervention research; What protects individuals and systems from breaking down when things go wrong in some circumstances?


Everyday Stressors and Social Suffering 

Housing and homelessness

Social Relationship

Ill health

Government 

Faith

Morals 


  1. Which model of resilience suggests that low levels of exposure to stress can actually promote better outcomes?
    a) Compensatory Model
    b) Challenge Model
    c) Inoculation Model
    d) Protective-Reactive Model
    Answer: c) Inoculation Model


  1. In the context of resilience, which of the following is a key difference between protective and promotive factors?
    a) Protective factors neutralize risk, while promotive factors encourage positive outcomes despite risk.
    b) Promotive factors are more effective in high-risk situations, while protective factors work better in low-risk situations.
    c) Protective factors mitigate risk, whereas promotive factors eliminate it entirely.
    d) Promotive factors operate in the absence of risk, while protective factors only work in its presence.

ANSWER: a) 















 Courage and Vulnerability 

Barriers to expressing vulnerability include-

-Stigmatization

-Sign of weakness 

ESPECIALLY BY THE CERTAIN GROUPS___

  1. Minority groups- stems from fear of further discrimination 

  2. Survivors of Trauma - fear of retraumatization and trust issues 

  3. Children- peer pressure 

  4. Men - toxic masculinity 



Toxic Masculinity

  • Promotes traditional male behaviour of “be a man,” “men don’t cry,” etc 

  • Encourages emotional suppression and reluctance to show vulnerability 


We can challenge by recognizing vulranbiluity is a sign of strength, not weakness, open conversations surrounding emotions an, mental health and coping skills. 


Resilience and Vulnerability can go hand in hand.

Vulnerability is an essential asset to building trust in relationships and developing deeper connections. This is why, inherently, women have deeper connections than men do, and that is why when female friendships begin to struggle, it is more painful and upsetting. 


Courage 

Capacity and strength to act meaningfully and with integrity in the face of acknowledged vulnerability. 

About connection and community 


TUTORIAL—-  People who come forward and open up about their trauma are courageous, and I admire them. 


I believe that vulnerability plays a huge role in creative expression as it can help others be vulnerable as well; movies, music, and artists opening up about their struggles can vastly help others. Relatable aspect. 


I think that as a society, we all need to do better and make everyone feel included and valued. I believe that one way we can continue to do this is by offering mental health resources and letting people know there are others who go through similar things. 


7. Attention or Time management?

Time and well-being are linked through the quality of life

Time itself is a precious commodity; it structures all of our days and the way we live

Time is closely linked to happiness, prioritizing 


Gallup Poll -

 48% of individuals feel as though they don’t have enough time to do the things they want 


Too much timeless enjoyment of activities 


Time use survey, different activities such as relaxing, leisure, socializing, and exercising. Tracked subjective well-being. Less than 2 hours of free time is a drop in subjective well-being. 2-5 hours of free time per day is ideal for wellbeing. 



Passive leisure= doom scroll

Active leisure = going and doing things, moving your body


Social connection is so important for wellbeing- brief interactions.


Time is a resource for health =

-Time needed for production and consumption 

- Time is needed to build social connections/ relationships, exercise, work, play and other activities 


Unequal access to time = value is assigned to time, economically saved or spent, shouldn’t be “wasted.” 


Parents who have newborn- total 10 hours of discretionary time per week 


Multidimensional = poverty and social exclusion


WHAT IS LAZINESS??????

  • Warning sign that something or some process is no longer working 

  • Hard work being emphasized over health and other life impacts 

  • People who are dealing with mental health struggles are labelled as lazy 


“I think when we start listening to laziness, we can really question a lot

of unfair social standards .... And it's just all of this drive towards

meeting a really arbitrary standard of perfection. When we stop pushing

ourselves to kind of overachieve by this completely arbitrary metric, we

can say, ‘OK, what actually feels good for my body? How do I actually

want to spend my time?”

  • Devon Price 



Pilot Study (2018)

 Multiple laughter yoga sessions improved psychological well-being by reducing tension anxiety while also lowering stress indicators. 




Problem with time management

  • Limited hours in the day tend to underestimate how long tasks take, which often makes us feel worse. 


Attention Management

-Limiting distraction 

- Getting things done at the right time when you’re motivated to do so 


Multitasking is ineffective, has decreased quality, hinders learning and information retention, and compromises creativity. 


Procrastination- Pay yourself first, limit your work in progress, resist the allure of middling priorities



Sleep 

We sleep because it’s for memory consolidation, emotional regulation, brain function and energy conservation. 


Circadian Clock- internal 24-hour clock, 8 hours in bed, 10-hour time period to eat within, usually 7 am-7 pm 

Klietman and Richardson Experiment = Spent six weeks in the darkness for a study that demonstrated humans have an internal circadian rhythm 


Variations in the Circadian cycle due to  

  • Genetics

A molecular clock consists of a network of timekeeping genes and their associated proteins, such as 

CRY

CLOCK

PER

Sex differences Females reach maximum lateness at 19.5 years old, while for men, it’s around 21 years old. They disappear at 50 when females begin menopause. 

  • Age 

  • Environmental Influences 

  • Medical Conditions



Early Birds
- .5 of the population

-commonly familial 


{ Sleep Cycles disordered }

JET LAG - treatments light exposure and melatonin consumption 

SHIFT WORK DISORDER - treatments  would be more traditional schedule

DELAYED SLEEP- trouble falling asleep or waking up 



CIRCADIAN MISALIGNMENT - leads to negative health outcomes, late chronotypes, and shift workers have a higher chance of ending up with depression. Long-term shift work leads to dementia and cancer  


!!Chronotype is like night owl or early bird!!

Knowing your chronotype is useful when making decisions and such 


Temperature influences sleep Thermoregulation is reduced during sleep, so the body will wake up to regulate temperature instead of staying asleep

•Sleeping in an environment warm enough to raise body temperature can reduce REM and Deep/slow-wave sleep


  • Blue light technology interferes with melatonin production in the brain 



SLEEP RESTORES AND REPAIRS

  • muscles, tissues and cells 


Immune function- produces and releases cytokinesis, reduces the production of antibodies


Brain Detoxification = Noriphinerphrine is boosted when we are awake, and levels go back down when we sleep. 

The glymphatic system becomes more active, facilitating the removal of waste products



Daylight savings = Higher rate of pregnancy loss when spring daylight savings time was within 21 days after embryo transfer



Sleep deprivation - too little sleep results in an increased concentration of hormone which makes you feel hungry. 

^Ghrelin Levels and lower Leptin levels 


Long term sleep deprivation increases the risk of Alzheimer’s, 



Mindfulness 

2 components

1. Self-regulation of attention, focus on immediate experience and moment

2. Attitude of curiosity, openness and acceptance 


Mindfulness has peaked more interest recently- Mindful activities

-Visualization                                                             -Sensory Awareness

- Colouring or drawing -Progressive relaxation

-Observing nature -Mindful Breathing 

-Journaling

-Gratitude practice  



!!Mindfulness is not equal to meditation!!

The practice of being present mentally and physically 

  • Intention

  • Attention

  • Attitude


Seminal Study By Jon Kabat Zinn

1979

Rationale- stress reduction and relaxation program 

  • Those who live with chronic pain were often told to just learn to live with pain

  • Mindfulness meditation was unfamiliar in the US


Based upon theoretical considerations of pain perception and attention

  • Pain signals somatic damage

  • Chronic pain = no benefit 

  • Development of a psychological model

  • Learned attentional and attitudinal shift 

METHODS

51 individuals with chronic pain -> 10-week program

- Three mindfulness practices 

-Group format

-Expectation of relief 

-Non-goal orientation

-Self-responsibility

RESULTS 

After 10 weeks

Reductions in mood disturbance and psychiatric symptoms 

Pain reduction maintained at - 2,5. 4 .  7. months 




Interventions

Stress reduction

Acceptance and commitment therapy 

Mindfulness-based cognitive therapy 

Dialectical behavior therapy 



Mindfulness-based stress reduction 

Implemented globally

Program    - 8weeks

2.5 hour classes

1 day of silence 

Practices include body scans and yoga. Sitting meditations, mindful eating and walking 


Mechanisms of Action

  • Attention regulation

  • Body awareness

  • Emotional Regulation

  • Change in perspective on the self

Physical Impacts 

  • Balances nervous system 

  • Lower blood pressure 

  • Pain management 

  • Improved sleep

  • Weight management 

  • Reduced inflammation

  • Heart health



Functional Changes

• Attention regulation

• Body awareness

• Emotion Regulation

• Memory Processes

• Inter-Hemispherical Communication

 

Structural Changes

• Cortical thickness

• Grey-matter volume

• Frontopolar cortex

• Sensory cortices and insula

• Hippocampus

• Anterior cingulate cortex (ACC), mid-cingulate cortex, and

orbitofrontal cortex

• Superior longitudinal fasciculus and corpus callosum




Happiness

Bhutanh constitution

  • 1. Psycological Wellbeing, life satisfaction, positive emotion, negative emotion

  • 2. Health - self-reported health status, disability, mental health

  • 3. Time use- work, sleep 

  • 4. Education- literacy, schooling , value

  • 5. Cultural diversity and resilience- cultural participation

  • 6. Community Vitality- donation, safety, family 

  • 7. Good governance- political participation, services

  • 8. Environment- Wildlife damage, ecological issues 

  • 9. Living standards- Assets, Income, Housing

 

Hedoic- satisfaction

Eudimonic- Fufilment with life 


Happiness’s effect on health 

  • Improved physical, better immune system and lower cardiovascular diseases 

  • More social- stronger networks and relationships

  • More productive- happy workers tend to make more money 

  • Better citizens- more likely to donate time and money 


Happiness found increased test scores!!


Social Support

Emotional

Appraisal 

Informational

Instrumental



Bradford Hill Criteria

  1. Temporality

  2. Strength

  3. Bilogical gradient 

  4. Consistency 

  5. Specificity

  6. Plausability 

  7. Coherence

  8. Analogy 

  9. Experiment 



Brain Sleep Detoxification

-glymphatic system in the brain becomes more active in the brain during sleep, resulting in the removal of waste products

-sleep deprivation leads to waste builduo in the brain and is linked to alzhimers


Sleep Deprivation= increase Ghrelin Levels and decrease of leptin levels 


Dr. Ann Masten - considering systems when understanding resilience is important for how it incorporates how people work with one another


London Taxi Study- increased grey matter in the posterior hippocampus 

Cantrill Ladder- measures of life satisfaction 


Toxic Masculinity- begins in early adolescence by everyday things, emotional suppression 


Multitasking is extremely inefficient, hinders memory and education 


Toxic Stress leads to epigenetic changes 


Music therapy- helps cancer paitents is the reduction in serum cortisol 


REM sleep- happens in cycles of 90 minuetes at a time 


Circadian Clock- translation and transcription feedback loops , molecular components= CLOCK / BMAL1

CRY

PER


Bucharest early intervention- investigate effects of ealy deprivation and institutionalization on social development 

 

Daylight savings and pregnancy- higher rate of pregnancy loss when day light savings occur within 21 days of embryo transfer