Anatomy Notes
Prefixes
Therm- means heat
Endo- means within
An Endotherm is an organism that maintains a constant body temperature (inner heat)
A / An/ Anano- means not, against
Dia- means complete
Ecto- means outer, outside
Hyper- means too much, excessive
Hypo- means too little, below normal
Peri- means around, surrounding
Pro- means before, infront
Retro- means behind
Sub- means below
Trans- means through, across
Terms
Arthro- Joint
Tuberosity- Rounded prominence
Cardio- Heart
Cephalo- Head
Costo- Ribs
Process- Projecting part
Hemo- Blood
Ilio- Pelvis
Myo- Muscle
Fossa- Groove or depression
Osteo- Bone
Suffixes
-algia means pain
-cyte means cell
-ectomy means removal
-emia means blood condition
-itis means inflammation
-oma means tumor, mass
-opsy means to view
Planes and Positions
Positions
The anatomical position is the description of any region or part of the body in a specific stance. In this position, the body is upright, directly facing the observer, feet flat and directed forward, upper limbs are to the side, and the palms are facing forward.
When the body is lying face up, it is in the supine position.
When the body is lying face down, it is in the prone position.
Anterior view: at or near the front of the body
Posterior view: at or near the back of the body
Midline is the imaginary line running down the middle of the body
Lateral means away from the midline
Medial means toward the midline
Superior View: positioned looking towards the head with the feet furthest away, showing the upper half of the body
Inferior View: positioned looking towards the feet with the head furthest away, showing the lower part of the body
Deep: away from the surface of the body
Superficial: close to the surface of the body
Distal: away from the attached end of a limb or the body
Proximal: toward the attached end of a limb or the body
Planes
Planes are imaginary flat surfaces that pass through parts of the body
Sections are cuts along a certain plane
Frontal Plane: divides the body into front and back portions.
Transverse plane: Divides the body into superior (top) and inferior (bottom) portions
Oblique plane: passes through a structure or the entire body at an angle.
Sagittal Plane: Divides a structure or the body vertically into left and right portions.
Movement within the planes is parallel to the planes
Movement
When the body is lying face up, it is in the supine position.
When the body is lying face down, it is in the prone position.
Flexion bends the joint or brings bones closer together
Extension straightens or opens a joint
Hyper-extension: movement beyond straightening
Abduction moves the limb laterally away from the midline of the body
Adduction moves the limb laterally toward the midline of the body
Inversion: The inner side of the foot moves up
Eversion: the outer edge of the foot moves up
Pronation occurs when the radius crosses over the ulna (palm of the hand turns down)
Supination occurs when the radius and ulna are next to each other (palm of the hand turns up)
Plantarflexion: pushing toes downward (pushing the gas pedal)
Dorsiflexion: pulling the toes toward the body (letting off the gas)
Internal Rotation: joint internally rotates, limb turns toward the midline
External Rotation: swing limb away from the midline
Body Cavities
Body Cavity: a space that protects internal organs
Two main Cavities: Anterior & Posterior
Ventral (Anterior) can be separated into even smaller cavities: Thoracic, Abdominal, and Pelvic
Thoracic Cavity- Lungs, Heart, Diaphragm is the floor of the cavity
Abdomino-pelvic Cavity- Largest in the body, Digestive Organs. Pelvic- holds reproductive organs and bladder

Dorsal (Posterior) can be separated into Cranial and Vertebral.
Cranial Cavity- brain
Spinal (Vertebral) Cavity- spinal cord
Cell Physiology
Basic Cell Functions:
obtain nutrients
perform chemical reactions to turn nutrients and oxygen into energy
Eliminate cell waste
Synthesize proteins for structure and growth
Control the exchange of materials from the environment
Move materials internally
Sense and respond to changes in the environment
Reproduction
Specialized Cells- form four primary types of tissue
Muscle
Nervous
Epithelial
Connective
Muscle Tissue- specialized cells for contracting (3 types)
smooth
cardiac
skeletal
Nervous Tissue- specialized cells for initiating and transmitting electrical impulses. Found in the brain, spinal cord, nerves, and special sense organs. Important for: Communication, Coordination, and Control
Epithelial Tissue- specialized cells for exchanging materials between the cell and its environment
Two General Types of Structures:
Epithelial Sheets- separate boundaries
Secretory glands- release substances: Endocrine & Exocrine
Connective Tissue- has relatively few cells dispersed within extracellular material: Connects, Supports, and Anchors Diverse Structures: Loose connecting tissue attaching epithelial tissue to deep structures: Tendons and Bones
Cell Structure
Shared Features: Plasma Membrane, Nucleus, Cytoplasm
Additional Cell Structures
Cytoskeleton- made of protein filaments; highways of the cell
Nucleus- control center; contains DNA
Ribosomes- make proteins
Endoplasmic Reticulum- protein & lipid production and transport
Vesicles- transport materials
Golgi Apparatus- sorts molecules
Mitochondria- makes ATP
Vacuoles- storage
Membranes and Transport
Biological Membranes: Selective barriers - Permeable to some substances and not others.
Cell Membrane Structure:
Separates cell interior from exterior
Lipid Bilayer- two layers of phospholipids
Proteins embedded in lipid bilayer
Membrane → Cytoplasm → Cytosol
Cell-to-Cell Adhesion:
CAM’s- cell adhesion molecules
Extracellular matrix- biological glue
Specialized cell junctions- velcro-like cohesion
Membrane Transport:
Membrane transport- substances that pass into or out of a cell through the plasma membrane
Permeable = substance can cross
Impermeable = substance cannot cross
Selectively Permeable = only some substances can cross
Two factors influencing whether a substance can cross:
Size of substance
Relative Solubility
Solubility- the ability of a solid, liquid, or gaseous substance to dissolve in a solvent
Diffusion:
Solute- substance that can be dissolved
Solvent- breaks apart solute (in the body is water)
Diffusion- when the solvent becomes part of the solution
Concentration- the amount of solute dissolved in specific amount of solution
Concentration Gradient:
Difference between the concentrations of a solute in two areas of a solution
In cells, a concentration gradient results from unequal distribution between particles outside the cell (extracellular fluid)
Creates a potential force to move substances through the membrane to achieve equilibrium
Transport:
Ways to transport is allowed
Active Transport- uses energy: Endocytosis, Exocytosis
Passive Transport- requires no energy: Simple, Facilitated
Cellular Respiration
Cell Metabolism- the processes that occur in a cell to maintain life: Anabolism, Catabolism
Human Metabolism- Calorie, Cellular Respiration, ATP
Adenosine Triphosphate (ATP):
Energy currency of the body
Cash to pay the price of running functions
Adenosine plus 3 phophates
Mitochondria
Energy organelles
Power Plants of the cell
Extraction of energy from the nutrients in food
Generate ~90% of the energy we need for functioning

Cellular Respiration:
Oxygen is used to make energy from glucose
Also called aerobic metabolism, aerobic respiration, and oxidative metabolism
Step 1 is Glycolysis to break down the 6-carbon sugar molecules
3 Step Process
Glycolysis (Anaerobic)
Krebs Cycle (Aerobic)
Electron Transport Chain (Aerobic)

Glycolysis:
Glyc=sweet and olysis= breakdown (Sweet breakdown)
Enzymes in the cytosol break down the glucose into 2 pyruvte molecules and 2 hydrogens and 2 NADH molecules and creates 2 ATP
Process requires 2 ATP so you only create a net of 2 more
Krebs Cycle (Citric Acid Cycle)
Acetyl-CoA molecules enter the cycle and produce:
6 NADH, 2 FADH, and 2 ATP
NADH and FADH2 move to the next step
Electron Transport Chain
Series of proteins in the mitochondrial membrane transfer electrons from donors to acceptors
Oxidative phosphorylation
Energy released by the electrons is used to generate ATP
*One molecule of glucose can produce 36-38 ATP
Metabolism and Energy Systems
Metabolism
Chemical reactions that occur in the body to maintain itself
Also called bioenergetics
Defined as the study of how energy is transformed through biochemical reactions
Thermodynamics:
First law of thermodynamics
Energy can neither be created nor destroyed, only recycled or converted from one form to another
In humans, this is the concept of energy balance- all of the energy of a human consumes is either used to perform body functions or stored within the body
Exercise Metabolism
The bioenergetics as it relates to the unique physiologic changes and demands placed on the body during exercise
Fuel for Metabolism
Substrates:
Proteins (chains of amino acids)
Carbohydrates
Fats
Glucose
One of the main sources of energy
Can be made in the body from other substrates (fats and amino acids)
Majority comes from carbohydrates
Stored glucose is glycogen
Fuel Needs and Exercise Intensity
Rest or Low-intensity activity = fats (lipids) primarily fuel the body
As intensity increases, the body transitions to using mostly glucose for energy
VT (Ventilatory Threshold) 1: metabolic marker for increased intensity that requires 50% glucose and 50% fat
VT2: metabolic marker for high intensity and the point at which glucose is providing almost all of the energy
Fat as Fuel
Source of energy for rest and low-intensity action
Triglycerides- free fatty acids
Excess calories are converted to fat
Utilized in aerobic metabolic pathway to produce ATP
Amino Acids as Fuel
Protein- made of long chains of amino acids
Humans use 20 different amino acids to assemble protein
9 essential amino acids
Utilized to build muscle and repair tissue
Can also supply energy for ATP if carb and fat sources are low
Gluconeogenesis- the process used to break down amino acids to use them for ATP production
Ketone Bodies
Ketogenesis- the formation of ketone bodies from amino acids
Ketone bodies- water-soluble molecules produced in the liver as a result of fatty acid oxidation or conversion of amino acids during gluconeogenesis
Anaerobic metabolization
Ketosis occurs when the metabolism creates ketone bodies to make up for lack of carbohydrate stores
Energy Systems
The human body is an organic machine that turns chemical energy into mechanical work
Phophorylation- addition of phophate to a molecule of ADP to make ATP
Three metabolic pathways:
ATP PC System (phosphagen)
Glycolytic system (glycolysis)
Oxidative system
ATP-PC (Phosphagen) System
First step in ATP gerating metabolic pathways
Also called phosphocreatine system
Called upon when body transitions to higher intesity actions
10-15 second duration
Anaerobic
Power forms of exercise
The Glycolytic System
Also referred to as glycolysis
Slightly slower anaerobic system
Turns free blood glucose or stored glycogen into pyruvate and ATP
Lasts for roughly 30-60 seconds but can be increased with high intesity training
The Oxidative System
Most compex of the three systems
Also called oxidative phosphorylation
Requires oxygen- Aerobic
Three substrates utilized:
Free fatty acids
Pyruvate (created during glycolysis)
Amino acids
All three substrates must be converted to AcetylCoA
Exercise Energy Needs
Defined by 2 factors:
Intensity
Duration
Inverse relationship
As intensity rises, the duration must go down
Energy Expenditure
Kilocalorie: kcal is the basic unit of energy that is provided by food
Total Daily Energy Expenditure (TDEE) is the number of calories that a person expends in 24 hours (varies for many reasons)
RMR: resting metabolic rate is the number of calories a person burns just living their daily lives
Physiological processes like digestion, respiration, heart function … etc
General activities like walking from one room to another at gome or typing on a keyboard at work or school… etc
Thermogenesis
Thermogensis is the metabolic process in which the body burns calories to produce heat
Exercise Activity Thermogenesis: Energy used when exercising
Non-exercise Thermogensis: the energy used for activites of daily living
Thermic Effect of Food: Energy used to digest food
In combination with RMR these three energy oyutputs combine to equal Total Daily Energy Expenditure
Measuring Human Energy Needs
estimate for most individuals’ daily calorie intake needs at rest:
The Mifflin-St Jeor equation, created in the 1990s, provides a valid estimate of RMR
Men: (10 x weight in kg) + (6.25 x height in cm) - (5 x age in years) +5
Women: (10 x weight in kg) + (6.25 x height in cm) - (5 x age in years) - 161
Energy Needs for PA
To calculate how mnay calories to add to your resting metabolic rate (RMR) for physical activity, you can multiply your RMR by a factor based on the intensity and frequency of your exercise:
Lightly active: Exercise 1-3 days per week and multiply you RMR by 1.375
Moderately active: Exercise 3-5 days per week and mutliply your RMR by 1.55
Very active: Exercise 6-7 days per week and multiplt your RMR by 1.725
To get your total calorie needs per day, adding your activity calories to your RMR will estimate how you might maintain your current body weight or acieve “energy balance“
Skeletal System
206 bones in the human skeleton
Divided into 2 sections
Axial- skull, vertebral column, and ribcage
Appendicular- upper and lower extremities
Axial vs Apendicular Skeleton
Axial includes cranium, thorax and vertebral column
Appendicular includes pevlis and lower and upper extremeities
What is a bone?
Living system of tissue with functions including:
Support: gives shape to the body and allows humans to stand
Protection: protects vital organs and structures
Movement: made possible by muscles pulling on bones
Storage of minerals: essential minerals stored in the bones
Blood: Blood cells are formed in the red marrow within certain bones
Shapes or Types of Bones
Long Bones: femur, humerus, tibia, fibula, radius, ulna
Short Bones: trapezoid (wrist bone), carpals, tarsals
Irregular Bones: pelvis, vertebrae, some facial bones
Flat Bones: scapula, sternum, ribs
Sesamoid: Patella (bones that protect tendons and ligaments)
Gross Anatomy of Bones
Bone Tissue:
Compact bone makes up the dense outer layer of bone. Its functional unit is the osteon. Compact bone is very hard and strong
Spongy bone is found inside bones and is lighter and less dense tha compact bone. This is because spongy bone is porous - this makes our weight lighter for efficient movement.
Bone marrow is a sot connective tissue that produces blood cells. It is found inside the pores of spongy bone.
Periosteum is a tough, fibrous membrane that covers and protects the outer surfaces of bone.
Bone Vascular Tissue and Nerves
Bones are supplied with blood and nutrients through a complex system of blood vessels
Nerve channels also run within bone tissue
Bone Development from Embryo to Adult
Bone development, ossification (osteogenesis), begins by the sixth or seventh week of embryonic life
Bone forms on a cartilaginous matrix
growth plates
The human skeleton is composed of 270 bones at birth - this total decreases to 206 bones by adulthood after some bones have fused
It is believed that peak bone density occurs between the ages of 18-25 years.
Remodeling of Bone
Ossification (or osteogenesis) is bone remodeling is the process of laying down new bone material by cells called osteoblasts. It is synonymous with bone tissue formation or remodeling
Bone tissue is continuously remodeled through the concerted actions of bone cells
Bone resorption is caused by osteoclasts
Bone formation is caused by osteoblasts
An imbalance between bone resorption and formation can result in bone diseases, including osteoporosis
Bone cells are triggered to break down or form new bone based on the levels of calcium and phosphorus in the blood
Anabolic vs. Catabolic
Anabolism
Process by which the body systems take smaller units like nutrients, cells, or amino acids and bonds the together to create bigger structures
Example: Osteoblasts are anabolic- the buid bone when stimulated by hormones in the body; healing after a wound is another example
Catabolism
Process takes larger structures like proteins, fats or tissues and breaks them down into smaller units
Example: Osteoclasts are catabolic- they break down bone and send minerals into the bloodstream; digestion is another example
Bone Injuries and Disorders
Fractures:
Fractures can be described by their location, the bone alignment, whether there are associated complications with blood and nerve function, and whether the skin is intact at the fracture site
Injury and Healing of Bone
Fractures- any loss of continuity of bone. Anytime the bone loses integrity, whether it’s a hairline crack or a shattered bone, it’s considered a fracture.
The bone healing process has three stages: inflammation, bone production and bone remodeling
Inflammation and clotting at the fracture site happen first. This provides the initial structural stability and framework for producing new bone.
As healing progresses into bone production, the clotted blood formed by inflammation is replaced with fibrous tissue and cartilage (known as soft callus). The soft callus is replaced with hard bone (known as hard callus)
Bone remodeling- the final phase of bone healing- goes on for several months. In remodeling, bone continues to form and becomes compact, returning to its original shape
Bone Bruise
Brone Bruises- less severe than a bone fracture and happens when a person sustains a traumatic blow extreme/repeated pressure, or a rotational or twisting force
The injury can cause bleeding and swelling in the central cavity of the bone where red and yellow bone marrow is stored
Osteoporosis
Osteoporosis: a bone disease that occurs when the body loses too much bone, has too little bone, or both. As a result, bones become weak and may break from a fall or even from sneezing or minor bumps in advanced stages. means “pourous bone“
Osteoporosis-related ractures most commonly occur in the hip, wrist or spine
Risk Factor: age, gender, ethnicity, genetics, body frame size
Treatment: For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates
Bisphosphonates are drugs that slow down or prevent bone loss by inhibiting osteoclasts.
Prevention is key!!
Weight bearing exercise- form follows function
Proper diet- ph balance in bloodstream is very important
Osteomalacia
Defined: softening of the bones, typically through a deficiency of vitamin D or calcium
People who live in areas where sunlight hours are short or eat a diet low in vitamin D ca develop osteomalacia
Celiac disease cna lead to malabsorption of vitamin D
Kidney or liver disease can interfere with body’s ability to make vitamin D
Medications can interfere with vitamin D absorption
Osteoarthritis
Defined: a degenerative disease in which the protective cartilage on the ends of bones wears down over time
Most commonly affects joints in your hands, knees, hips, and spine
No specific cause. Several factors lead to the development of OA, including excess weight, injury or overuse and genes
Scurvy
Defined: Scruvy is the name for a vitamin C deficiency
Vitamin C is important in the formation of collagen, a connective tissue of the body
Cartilage
Cartilage has no nerves or blood supply
There are three types of cartilage tissue: hyaline, elastic, and fibrocartilage
Cartilage is surrounded by a dense tissue membrane called a perichondrium
Types of Cartilage
Hyaline
The most prevalent type of cartilage and is flexible yet resilient
Covers the end of bone, connects ribs to sternum, is the skeleton of the larynx, supports the external nose
Elastic
More elastic than hyaline
Found in the external ear and the epiglottis
Fibrocartilage
Highly compressible but lots of tensile strength
Found in thick pad-like structures like the menisci of the knee or the discs of the vertebral column.
Overview of Major Bones
Major Bones in Human Skeleton- Axial
Core of human body protecting vital organs: 80 bones
29 bones in the head - (8 cranial and 14 facial bones) and 7 associated bones (6 auditory ossicles and the Hyoid Bone)
25 bones of the thorax - (the sternum and 24 ribs)
26 bones in the vertebral column (24 vertebrae, the sacrum and the coccyx)
Cranium
The cranium supports the structures of the face and protects the brain
Composed of two parts: cranium and mandible
Made up of a number of fused flat bones
Contains foramina (openings), processes (projections) and several cavities or sinuses
Sutures of the Skull
Coronal Suture: junction between the frontal and parietal bones
Sagittal Suture- junction between the two parietal bones
Lambdoid Suture- junction between the parietal and occipital bones
Fontanelle- soft spot or space between the cranial bones
Cranial Sutures
Degrees of suture ossification
A. Degree 1- suture clearly visible
B. Degree 2- dashed suture line with some tracks of complete fusion
C. Degree 3 only traces of suture remain
D. Degree 4- suture is completely fused
Male and Female DIfferences in Skull
Subtle differences in male and female skull:
Women have a more rounded frontal bone; men have less rounded and sloping frontal bone
Male skull is larger and heavier
Women’s eye sockets are more rounded; men’s are more sqaure
Spinal Bones
Adult spine consists of 26 bones
24 presacral vertebrae (7 cervical, 12 thoraic, and 5 lumbar)
sacrum (5 fused sacral vertebrae)
coccyx (4 frequently fused coccygeal vertebrae).
Prior to adolescence, the spine consists of 33 bones because the sacrum’s five bones and the coccyx’s four do not fuse until adolescence
Rib Cage
A human rib cage consists of 24 ribs, the sternum (including xiphoid process), costal cartilage and 12 thoracic vertebrae
Fixed ribs- first seven rib pairs
False ribs- eighth-to-twelfth pairs of ribs. The eighth-to-tenth pairs of ribs connect to the sternum indirectly via the costal cartilages of the ribs above them. Their elasticity allows ribcage movement for respiratory activity.
Floating ribs: the 2 lowermost rib pairs (eleventh and twelfth); they are attached only to the vertebrae but not to the sternum or cartilage of the sternum
Major Bones in Human Skeleton- Appendicular
Bones of the Appendicular seleton:
4 bones in the shoulder girdle (clavicle and scaula each side)
6 bones in the arm and forearm (humerus, ulna, and radius)
58 bones in the hands (carpals 16, metacarpals 10, phalanges 28 and sesamoid 4)
2 pelvis bones
8 bones in the legs (femur, wtibia, patella and fibula)
56 bones in the feet (tarsals, metatarsals, phalanges and sesamoid)
Shoulder Girdle
Anchor sthe appendicular skeleton to the axial skeleton at the top
Consists of a complex of five joints
Arm/Forearm
Humerous
Radius
Ulna
Hand and Wrist Bones
Carpas
Metacarpals
Phalanges
Pelvis
Connects the lower appendicular skeletonto the axial skeelton at the sacrum
In adults, each hipbone consiss of 3 fused bones
Ilium
Ischium
Pubis
Male vs Female Pelvis
Angle of pubic arch
Coccyx or tailboen in males is projected more inwards
Female sacrum is wider and shorter
Angle of acetabulum is more vertical in females
Pelvic inlet in women more oval shape and larger
Leg Bones
Femur (largest bone in body)
Patella or knee cap
Tibia
Fibula
Foot and Ankle Bones
Tarsals
The calcaeus and talus, navicular, cuboid and 3 cuneiforms
Metatarsals
Phalanges
Joint & Joint Structures
Types of Joints in Human Body
joints allow for movement of the human body
Synovial
Fibrous
Cartilaginous
Joint Classification and Movement
Joint names are typically derived from names of the bones involved
Joint classification is according to the manner in which the adjacent bones are bound to one another and how freely the bones can move
Fibrous Joints
Joints that are held tightly together by fibrous connective tissue
Lttle to no motion
No joint cavity
Examples: sutures of skull, tooth in a jaw, articulation between the radius and ulna; tibia and fibula
Syndesmosis
Slightly movable fibrous joint in which bones are joined together by connective tissue
Typically found between the long bones of the body
Also knows as “fixed joints”
Example: the tibia and fibula; radius and ulna
Interosseous membrane
Cartilaginous Joints
Bones connected by cartilage
Pad of cartilage lies between ends of bones
No joint cavity
Typically, little to no motion
Examples: Pubic symphysis, costochondral joints of ribs, sternum, epiphyseal plates in growing bones, vertebral discs
Synovial Joints
Most moveable
Ends of the bones are covered with articular cartialge
Have a joint cavity separating the articulating bones
Has a joint capsule enclosing the joint
Lined with synovial membrane that helps lubricate joint with synovial fluuid
Examples: hip, shoulder, elbow, knee
Structure of a Joint
Joints are complex structures consisting of bone, muscle, synovium, cartilage, and ligaments
Joint Structures
Articulating bones
Bones that come together and ofrm the jointwhere movement happens
Joint Capsule
Fibrous capsule surroudning the joint
Connected to the outer layer of the ends of the bones that come together
Reists dislocation
Synovial membrane
Loose connective tissue inside the joint capsule that contains elastin and fatty tissue
Secretes synovial fluid, which lubricates the joint
Meniscus
Also called “cartilage”
Pads (kind of like a pillow) that enable articulating bones whose shapes do not match each other exactly to fit more snugly together
Ligaments
Hold bones together at a joint
Intracpsular- located inside the articular capsule and surrounded by folds of synovial membrane
Extracapsular- located outside of the articular capsule, and an may be fused with (attached to) the joint capsule
Bursae
sac-like structures thfat reduce friction between bones
Joint Movement:
Synovial joint movement occurs within all three planes of motion: sagittal, frontal, and transverse
Uniplanar- movement in one direction
Elbow, knee
Biplanar- allow movement in two planes that are perpendicular to each other
Finger
Multiplanar- allow movement in all three planes
Hip, shoulder
6 Types of Synovial Joints
Plane/Gliding Joints
Examples: calvicle and scapula (AC joints); intercarapal and intertarsal joints; Multi-axial joint but limited by surroudning ligaments
Articular surfaces are flat
Condyloid/ Elipsoidal Joint
Articular surfaces are oval concave on one side and convex on the other
Examples:
metacarpal/phalanges (knuckles); metatarsal/phalanges (toe knuckles)
Biaxial- move in two axis
Ball and Socket Joints
Multiaxial- all three planes of movement
One end of bone is rounded and articulates into a cup like socket
Examples: hip; shoulder
Hinge Joints
Uniaxial- allows flexion and extension
Conves surface fits into a concave depression on other bone
Examples: elbow, knee
Saddle Joint
Biaxial- flexion & extension, and abduction and adduction
One surface is concave like a saddle, and the other is convex
Example: Thumb (metacarpal-trapezium) or calcaneal-cuboid joint
Pivot Joint
Uniaxial
One articular bone iwth rounded surface fits into a ring formed by a ligament on another bone
Pivots around an axis
Examples:
proximal radial/ulnar joint that allows the radius to rotate as you pronate and supinate your hand
Atlas (C1) and Axis (C2) joint allows you to shake your head “no”
Joint Examples
Ball and Socket: hip and shoulder
Pivot: vertebrae
Hinge: elbow and knee
Four Groups of Movement in Synovial Joints
Gliding- surfaces of 2 bones move back and forth upon each other
Head of a rib and adjoining vertebra
Angular- increase or decrease in angle between adjoining bones
Flexion of lower arm toward the humerus
Circumduction- sequential combination of flexion, extension, abduction, adduction
Shoulder or hip circle motion
Rotation- motion of a bone around a longitudinal axis
Pronation or supination of the hand/arm from the shoulder joint
Hilton’s Law
A nerve trunk that supplies a joint also supplies the muscles of the joint, tissue, and the slin over the attachments of such muscles
This is important in that if an individual is injured, it is sometimes difficult to determine if the pain the person feels is coming from the muscle or joint
Pain from one injured or irritated area can radiate to other areas
Myofascial release and massage therapy works on an individual’s superficial tissues, it can cause a release of deeper tissues
Joint Diseases
Osteoarthritis- also called degenerative joint disease
Painful condition affecting the ends of bones
Hyaline cartilage on the ends of bones and cartilage between bones, start to degenerate or wear away
Rheumatoid Arthritis- autoimmune disorder where the immune system attacks the lining of the joint
Causes painful swelling, bone erosion, and joint deformity
Physics of Joint Movement
Three classes of lever are found in the human body, with fulcra are usually situated at the joint
All movements of the human body are dependent on the interaction of these three classes of levers
Levers in the Body
A first class lever is used in balancing weight and/or changing the direction of pull
There is usually no gain in mechanical advantage
A second class lever (think of weight lifted in a wheelbarrow)
It gains mechanical advantage therby allowing large loads to be moved, but with a loss of speed.
Raising up onto the toes is an example of such a lever system; the metatarsal heads act as the fulcrum, the weight of the body acting down through the tibia is the load while the calf muscles contract to produce the required force.
A third calss lever is the most common lever found within the body. It works at a mechanical disadvantage moving less weight but odften at great speed
the biceps brachi acting across the elvow is a good exampel of this calss of lever
The albow is the fulcrum, the weight is the forearm and hand being supported, with the ofrce being provided by biceps
Kinetic Chain
Many movements in the human body involve multiple joints
Kinetic chain: The (sometimes called the kinematic chain) is an engineering concept used to describe human movement
Body segments are connected via joints, and this creates a system where movement produced at one joint affects movement at another joint in the kinetic link
Closed Kinetic Chain
In a clsoed chain exercise, the end of the joint chain is fixed, or stationary
Examples: leg press machine, pushup, lung
Open Kinetic Chain
Open kinetic chain exercises, the segment furthest away from the body - known as the distal aspect, usually the hand or foot is free and not fixed to an object
Examples: throw, kick, chest fly with dumbells
Kinetic Chain Exercises
Athletic trainers, physical therapistsm chiropractors, and personal trainers use kinetic chain exercises to help with injury prevention and recovery, body scultping, and performance enhancement
Stretching vs. Strengthening Muscles
Definitions:
Stretch
Putting a body part in a position that promotes lengthening and elongation of the muscle or muscle group and improves its flexibility and elasticity.
Strengthen
Strengthening exercises overload the muscle until the point of muscle fatigue. This force and overload of a muscle ecnourages growth, increasing the strength.
Stretching:
Why Stretch?
Mobility
Injury reduction
Promote relaxation and joint health
How to stretch?
Move muscle insertion away from muscle origin
Dynamic vs static
When to stretch
Cool-down phase of a workout
Muscles must be warm
Flexibility
Ability to move a joint through its complete ROM
Static vs functional
Affected by various factors and structures
Flexibility Stretches
Static
Hold between 15-30 sec
Warm tissue is more elastic
Dynamic
Should mimic sport activity
Several reps, increasing in speed and intensity
Strength
Why strengthen?
Maintain mobility
maintain healthy body composition
Bone density
How to Strengthen
Bring muscle insertion closer to muscle origin with resistance
When to strengthen?
2-4 times per week
After a dynamic warm-up
Examples:
Isometric: muscular contraction with no movement
Isotonic: muscular contraction where the muscle shortens (concentric) and/or lengthens (eccentric)
Definitions:
Muscular Endurance:
Muscle’s ability to continue to perform successive exertions or many repetitions
Examples: sit-ups, push-ups, exercises of 12 or more repetitions
Muscular strength; Maximum force a muscle or muscle group can exert
Example: Bench press, squat; goal is lifting heavier weight, not repetitions
Muscular Power: strength applied over a distance for a specific amount of time
Example: Vertical jump, power clean, quick, explosive movements
Functional Training
Functional strength and mobility preserve the ability to perform motions needed to fulfill daily tasks as the body ages
Focus on ROM for stretch training
Focus on muscular balance in strength training
Include all fundamental movements: push, pull, rotate, lunge/step, squat/, balance, hinge
The Muscular System
Muscular System
An organ system consisting 3 muscle types
Skeletal
Smooth
Cardiac
Controlled through the nervous system
Voluntary
Involuntary
Muscle Types
Three types of muscle:
Skeletal
Attaches to the skeleton via tendons, contracts to move bones
Voluntary
Striated appearance
Smooth
Found on the walls of hollow organs and tubes (stomach & blood vessels)
Involuntary
Smooth appearance
Cardiac
Forms the walls of the heart
Involuntary
Smooth appearance
Functions
Permits movement of the body
Internal
External
Maintains posture
Body temperature regulation
Movement of lymph
Characteristics of Muscle
Defining qualities of muscle tissue function:
Excitability- ability to react to stimulus
Contractility- ability to shorten
Extensibility- ability to lengthen
Elasticity- ability to return to original resting length
Muscle Architecture
Parallel- most common
Non-fusiform- length of the fibers run parallel to the long axis of the muscle- flat shaped
Fusiform- more spindle-shaped; diameter at the center is greater than at either end
Circular- surround body openings
Convergent- broad origin converges toward a single tendon of insertion
Pennate- the fibers are short, and they attach obliquely to a central tendon that runs the length of the muscle
Unipennate- insert into only one side of the tendon
Bipennate- insert into the tendon from opposite sides so the muscle “grain” resembles a feather
Multipennate- like many feathers side by side, with all their quills inserted into one large tendon
Function Based on Fiber Arrangement
Circular- fibers increase the size of the opening, and when they contract, the size of the opening shrinks to the point of closure
Convergent- can adapt to different activities by stimulating different regions
Parallel- greater range of motion and speed of contraction, but less force
Pennate- only pull at an angle
produce relatively more tension for its size
Muscular Anatomy
Skeletal muscles are made up of many muscle fibers held in place by connective tissue (fascia)
Fascia is a band or sheet of superficial connective tissue made up primarily of collagen, that attaches, stabilizes, encloses, and separates muscles and other internal organs
Fascia
*provides support and structure throughout your body, holds muscles together
Superficial- the lowermost layer of the skin in nearly all regions of the body
Deep- a layer of dense, fibrous connective tissue that surrounds individual muscles and also divides groups of muscles
Visceral- supports organs within their cavities and wrapos them in layers of connective tissue
Fascia Troubles
Fascia looks like one sheet of tissue but has many layers
Liquid in between called hyaluronan
Factors that cause fascia to become gummy and crinkle up (adhesions: sticky, rigid spots that stick to nearby muscles and bones) include:
Physically inactive lifestyle
Repetitive movement
Trauma such as surgery or injury
Layers of Muscular Tissue
Fascia
Epimysium
Perimysium
Endomysium
Sarcolemna
Microanatomy of a Muscle
Muscle fibers are made up of myofibrils (protein filaments) composed of a series of repeating segments called sarcomeres
Sarcomeres, made up of thick (myosin) and thin (actin) myofliaments, are the functional contracting unit of skeletal muscle
Muscular Contraction
Sliding Filament Model
When acetylcholine (neruotransmitter) is released from the CNS and detected, calcium is released.
Calcium exposes binding sites along the actin for the myosin to attach.
If sufficient ATP is present, cross-bridges are formed and the myosin pulls the actin toward the center, thereby shortening the sarcomere.
Skeletal Muscle Fiber Types
Divided into two general categories based on how quickly they contract
Slow-twitch muscle fibers contain relatively large amounts of mitochondria and are surrounded by more capillaries than fast-twitch fibers.
Contract more slwoly than fast-stwitch fibers
Have lower force outputs, but are more fficient and fatigue-resistant than fast-twitch fibers- high aerobic capacity
Fast -twitch muscle fibers high capacity for anaearobic power
Tpye IIX muscle fibers
Contain a relatively small amount of mitochondria, have a limtied capacity for aerobic metabolism, and fatigue more easily than slow-twitch fibers
Have considerable anaerobic capacity, adn are the largest and fastest, and are capable of producing the most force, of all the skeltal muscle fibers.
Type IIa muscle fibers
Possess speed, fatigue, and force-production capabilities somewhere between type I and type IIx fibers
Type IIa fibers are also called intermediate fibers- can adapt to limited aerobic capacity
Proprioception
Proprioception is the sense of the orientation of one’s limbs in space
Without proprioception, humans would need to consciously watch their feet to make sure to stay upright while walking
The primary proprioceptors involved in muscular control and coordination are the Golgi tendon organs (GTO) and muscle spindles
Give information about muscle length, tension, and joint movement
Muscle Spindles
Found in the Muscles
Function to prevent muscles from overstretching by activating “stretch reflex”
Golgi Tendons
Located in the tendons
Prevents muscles from over-contracting and promotes involuntary relaxation
Prevents injury by causing the muscular contraction to release rather than tear
Proprioceptors
Provide information about movement and perception
Trigger protective responses
Proproception vs Kinesthesia
Proprioception is related to position and balance or cognitive/ subconscious awareness of your body in space
Kinesthesia is related to movement of your body in a behavioral sense- you can make conscious movement adjustments depending on the task or goal of movement
Tendons
Connect muscle to bone by fusing with the epimysium of the muscle and the periosteum of bone
Aponeurosis- like a tendon but flat- also connects muscle to bone
Tough, cord-like fibrous conncetive tissue - more collagen than elastic fibers
Transmit force from the muscle to the bone causing movement
Ligaments
Supports a joint by attachign bone to bone
Contain a greater mixture of collagen and elastic fibers than tendons
Muscular Function Terminology
Main function is voluntary and involuntary movement
Origin is where the tendon attachment of muscle begins and the less mobile of the two bones that make up a joint
Insertion is where the muscle ends and the more mobile of the two bones that make up a joint
Prime mover or agonist, is the muscle contracting
The opposing muscle or antagonist, is the muscle that is extending
Origin and Insertion of a Muscle
Origin is the site of muscle attachment that DOES NOT move when the muscle is contracted
Insertion is the site of the muscle attachment that DOES move when the muscle is contracted
Types of Muscular Contractions
Isometric (static)- length of muscle stays the same- joints dont move
Isotonic (dynamic) joint movement occurs
Concentric phase- shortening muscle-lifting phase- flexion
Eccentric- lengthening and contracting- down phase- extensions
Isokinetic (specialized equipment needed to control speed of contraction) used in rehab facilities
Muscle Movement
Agonist-Primary Movers: primarily responsible or generating the movement; concentric phase (up phase)
Antagonists- Oppose primary movers; usually lie opposite of the primary movers
Synergists- muscles that assist primary movers; smaller muscles that help
Stabilizers- prevent movement; isometric contraction
Movement Phases
Conentric Phase
The “up” phase of an exercise. When the gravity/weight is being lifted. Ex: stadning up from a seated position
Eccentric Phase
The down phase of the movement. When the gravity/ weight is being lowered . Ex: slowly sittign down
Strength vs. Endurace
Strength
The ability of a muscle or group to contract
How much resistance can muscle overcome
Endurance
Ability of muscle to contract sub-maximally repeatedly
How long can a muscle hold a weight
Strengthen vs Stretch
Strength is the ability of a muscle to overcome a resistance
Requires a muscle to contract against a resistance
Stretch isthe ability of a muscle to lengthen through a range of motion or ROM
Requires tnesio nto be placed on a muscle to lengthen it beyond its resitng length
Muscle Conditions or Injuries
Muscle Strain- Muscles and/or tendons are damaged
Ligament Sprain- Damage to a ligament
Both injuries have degrees of severity
First degree- stretched tissues but not torn
Second Degree- some of the tissue is torn
Third Degree- completely torn tissue
Nervous System
Functions: Collect information about the body’s external state, analyze it, and initiate appropiate responses.
Nervous System Structure
Divided into the central nervous and peripheral nervous system
The CNS consists of the brain and spinal cord
The PNS consists of all the nerve structures outside the brain and spinal cord
Sensory Division - picks up sensory stim
Motor Division - sends directions to te muscles or system
CNS
Brain
The command center for the human nervous system
Contains about 86 billion nerve cells (neurons)
Spinal Cord
The spinal cord is located in the vertebral foramen and is made up of 31 segments
Electrical currents tracel up and down the psunal cord, sending signals which allow different segments of the body to communicate with the brain
Brain
Made of 3 main parts: The Cerebrum, Cerebellum, and the Brainstem
The largest part of the human brain is the cerebrum, which is divided into two hemishperes
Protected by the skull sespended in cerebrospinal fluid and isolated from the bloodstream by the blood-brain barrier
Meninges
3 protective layers of Brain and Spinal Cord
Dura Mater
Outer layer, thick and tough (bark on tree)
Arachnoid Mater
Web-like, allows for shock absorption, middle layer
Cerebrospinal fluid is found in the subarachnoid space
Pia Mater
Deep and vascular, soft for protection of brain matter
Meningitis
Causes compression or pressure on the brain and spinal cord
Usually involves the arachnoid mater annd pia mater
Two Main Types
Bacterial: can be cured using antibiotics
Viral: not typically as sever but antibitotics dont work, immune system responds (can be deadly)
Fungal, Parasistic, amebic form but are very rare
Spinal Cord
Runs form the foramen magnum where it is continuous with the medulla to the level of the first or second lumbar vertbra where it tapers and then becomes the Cauda Equina
Housed inside the vertebral foramen
Spinal cord is sheathed i nthe same three meninges as is the brain: pia, arachnoid and dura mater
The Spinal Cord is 40-50 cm long and 1 cm to 1.5 cm in diameter
2 consectuive rows of nerve roots emerge on each of its sides to form 31 pairs of spinal nerves
Carries sensory information (sensations) from the body to the brain via afferent fibers
Reflex Loop
Sometimes called reflex Arc
Allows for faster reflex action
Decision made in spinal cord by interneuron in the gray matter
Spinal Cord Cross Section
31 pairs of spinal nerves emerge from the spinal cord and pass thorugh the intervertebral foramina
Ventral root is at the fron of the spinal cord
Dorsal root is at the back of the spina lcord
Ventral and dorsal roots merge to from the spinal nerve
Ventral root carries efferent impusles - motor nerves
Dorsal root carries afferent impusles- sensory nerves
Peripheral Nervous System (PNS)
Made up of nerve fibers and nerbve cell bodies that connect the CNS to perihperhal structures (glands, organs, muscles)
The PNS can be divided into 2 compontes - the afferent division and the efferent division
Afferent information is sent towards the nervous system regarding the environment of the body (sensory)
The efferent division sends information from the nervous system to the organs of the body which then carry out the approprate response (motor)
Peripheral Division
Somatic- voluntary system directs skeletal muscles
Affferent (Sensory)
Efferent (Motor)
Autonomic- involuntary system that directs functions like heartbeat, breathing, digestion (innervates viscera, smooth muscles and glands)
Afferent (Sensory)
Efferent (motor)
Sympathetic
Parasympathetic
Enteric
Response to Stress or Stimuli
Parasympathetic Nervous System
In control when the body is at rest
Kee[s heart rate., blood pressure, and metabolism low
Sympathetic Nervous System
In control when body is exerpeincing stress (flight or fight)
Signals to the adrenal glands to release hormones epinephrine and noreoinephrine (catecholamines), and cortisol
Catecholamines cause higher heart rate and faster breathing, muscle tenion; Cortisol increases blood sugar by inhibting insulin
Vagal Response
Vagus Nerve
10th cranial nerve
One of main nerves of the parasympathetic nervous system
Sensory and motor functions
Responsible for calming organs after stress response
Primarily measured through its influence upon heart rate
Exercise (a form of stress) activates sympathetic nervous system
Vagal Withdrawal
Defined: decreases in vagal activation
Happen during exercise and other stressors
After exercise vagal withdrawal is inhibited
Nerves and Neurons
Nerves are made up of mutliple nerce cells called neurons
Neuron Structures
Neurons share the same basic strctures
Cell Body- soma; this is the cells life support system with a nucleus, DNA, mitochondria, ribosomes, cytoplasm
Dendrites- branch like projections from the soma; they are the “listeners” that pick up information from other cells and convey it to the cell body
Axon- long extension or fiber; some are short but others can be up to a meter long; they are the “talkers” that transmit messages away from the cell body to other cells
Additional Neuron Strcutres
Myelin Sheath - surrounds axon to help increase veolicty of impulse conduction
Synapse- point of contact between neurons (where neurotransmitters are released to either excite or inhibit antoehr neuron)
Schwann Cells- (a typer of glial cell) are cells which wrap aroudn axons of motor and sensory neurones to form the myelin sheath
Nodes of Ranvier- a gap in the myelin sheath of a nerve, ebtween adjacent Schwann cells
Neurons
Sensroy- have dendrites on both ends, long axon and cell body in the middle
Motor- cell body on the end, dendrite on one side, and on the other,m a long axon
Associative (interneurons or relay neurons) neither sensory nor motor but connect neurons with other neurons
Glial Cells
Neurons only really make up a small part of yoru nervous system; they are outnumbered by glial cells
The “glue” holds neurons toegther and help maintain homeostasis in the bervous system
Found in both the CNS and PNS
CNS Glail Cells include: Astrocytes, Microglial Cells, Epndymal Cells, Oligodenrocytes
PNS Glial Cells include Satellite Cells and Schwann Cells
Also different glaicl cells perform many functions from support, insulation, assist in signal transmission, insulation, immune defense, and anchoring neurons to their blood supply.
How Nerves Transmit Signals
The nervous system is your body’s “communication superhighway”
First a sensory neuron is excited by a stimulus such as sound, rpessure, temperature chagne or an image
Next neurons carry messages in the form of electircal signals called nerve impusles; the travel from the dendrites to the cell body then down the axon to a synapse
Finally, at the synapse (gap separating neurons) neurotransmitters (chemical messengers) interpret the mesage to the next neuron’s dendrite and the mesage travels on to the CNS
Damage to Nerves
Peripheral nerves are fragil and can be easily damaged
Damge can include: compression, stretching, or a nerve cna be severed
Examples: Carpal tunnel sysndrome
Accidents or sport injuries
Metabolic diseases such as diabetees
Peripheral neuropathy- a result of damage to your peripnheral nerves; usually because of disease
pain can be stabbin, burning or tingling
Motor Unit
Definition: A motor unit is made up of a single motor neuron as well as all of the muscle fibers that neruon acitvates
Muscle fibers are activated by motor neurons when they recieve signals from the brain to contract the msucle
A single motor neuron can control several hundred muscle fibers at a time (large muslce like gluteal muscle) or for more finite musclular movement (lik eye movemnt) a single motor unit may control a single muscle fiber
All or None Principle
the all or non law is a principle that states that the strength of a repsonse of a nverve cell or muscle fiber is not dependent upon the strength of those stimulu
In skeletal muscles, not all fibers will be stimulated during the same interval, but for the ones recruite- there will either be a full reponse or there will be no response at all for an individual neruon or muscle fiber
What does that mean for skeltal muscle?
Not all fibers will eb stimulated ruing the same interval
You cannot partially contract a muscle fiber- it all contracts or it doesnt
Proprioception
Proprioception- is the sense of the orientation of one’s limb in space
Proproocepteors are found within the synovial hoin capsules
Without proprioception, humans would need to consciously watch their feet to stay upright while walking
The primary receptors involved are the golgi tendon organs and muscle spindles
Musculotendinous Receptors
Two Types of Musculotendinoues Receptors:
Muscle Spindle
Located in the muscle belly lying aprallel to the fibers
Causes a reflexive contraction (stretch reflex) the muscle when the muscle senses a stretch force (rotective mechanism)
Simultaneously causes the antagonist to relax (reciprocal inhibition), allowing contraction to happen
GTO
Located between te muscle belly and its tendon
Causes msucle inhibition (autogenic inhbition) tells the msucel to stop contracting when it senses tension, allowing further muscle stretching to happen and preventing tearing of tendon from bone in extreme cases. (Trainer wants to activate GTO to allow flexibility improvement)
Disorders of the Nervous SYstem
THere are more than 600 neurological diseases. Major types encuntered in Exercise Science field:
Multiple Sclerosis- Commonly referred to aS MS< mutliple sclerosis - autoimmune disorder that affects the central nervous system - the brain and spinal cord. Individual with MS may suffer muscualr spasticity, weakness, vertigo, abnormal gait, and general weaknessw
Fibromyalgia- a chroniz pain state in which the nerve stimuli causing pain origincates mainly in the tissues of the body- characterizes by widespread musculoskeltal pain accompanied by fatigue, sleep, memory and mood issues
Parkinson’s - a chronci and progressive movement disorder, involves the malfunction adn death of vital nerve cells in the brain, leaving a person unable to control movement normally
ALS- Amyotrophic lateral sclerosis- is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord; The progressive degeneration ofw the motor neurons in ALS eventually leads to their demise, and control of muscle movement is lost
Muscular Dystrophy- a group of diseases that cause progressive wekaness and loss of muscle mass; symptoms of the most common variety begin in childhood, primarily in boys.
Epilepsy - abnormal electrical activity causes seizures
Vasovagal Syncope- vagus nere overreacts to a trigger and can cause a suden drop in heart rate and blood preasure, resulting in fainting
Low vagal tone- associated with attention and mood disorders
Sensory Processing Disorder- a group of disorder wehre a person’s proprioceptors that do not function properly causing them not to have good spatial awareness or sensation of force or tension.
Human Brain
Brain Cells
Neurons
Transmit information
Glial Cells
Oligodendrocytes
Microglia
Astrocytes
Endothelial Cells
Line blood vessels
Blood-brain barrier
Brain Divisions
Cerebrum
Diencephalon
Cerebellum
Brainstem
Cerebrum
Largest part of the brain
Conscious thoughts and actions
Five senses
Language
Logic and Reasoning
Behavior and Personality
Working Memory
Diencephalon
AKA Through Brain
Connection between cerebrum and rest of the nervous system
Rest of brain, spinal cord and PNS all send info to cerebrum through the diencephalon
Thalamus: All sensory info (minus smell); processes info
Hypothalamus: Regulated homeostasis
Cerebellum
Comparatively small (little brain)
Holds more than half the neurons in the body
Plays a role in emotions and decision-making
Damage can impair verbal skills, balance, motor skills, and judgement
Compact tissue
The Brainstem
Midbrain
Hearing, motion, environmental changes
Pons
Origin of 4 cranial nerves
“bridge” between midbrain and medulla
Medulla
Essential for survival- controls breathing, heart rhythm
Gray Matter
Densely packed neurons
Found in outer layer of cerebrum, deep inside cerebrum, on the oter layer of the cerebleem, and inner layer of spinal cord
Processes information, thoughts, memories, feelings, emotions, sensory input, muscle motion
White Matter
Found deep in brain and in the outer portion of spinal cord
Consists primarily of axons wrapped in myelin sheath that connect Neuron
“Communication Cables”
Carries signals between areas of gray matter
Learning, recall, balance, walking, emotions
Brain Injury
Traumatic Brain Injury (TBI)
Causes
Blow to the head
Object penetration to the head
Symptoms
Can be physical, sensory, or cognitive/behavioral
Treatment
Rest and OTC pain relievers fr mild TBI
Emergency are for moderate to severe
Concussion
Mild to Moderate TBI
Damage
Symptoms
Can be physical, sensory, or cognitive/ behavioral
Stroke
Ischemic
Hemorrhagic/aneurism
TIA (transient ischemic attack)
Complications
Loss of msucel control
Cognitive or memory issues
Difficulty talking or swallowing
Behavioral or emotional changes
Diseas that Affect the Brain
Amyotrophic Lateral Sclerosis (ALS)
Multiple Sclerosis
Muscular Dystrophy
Epilepsy
Brain TUmors
Autism
Demntia
Alzheimers
Parkinsons