Chapter3/Exam1

Functions and Activities of the Brain

  • The brain is responsible for the maintenance of homeostasis within the body.

  • It regulates the Autonomic Nervous System (ANS\text{ANS}) and the production and release of hormones.

  • It is the control center for biological drives and behavior.

  • It manages the cycle of sleep and wakefulness.

  • It regulates circadian rhythms.

  • It facilitates conscious mental activity.

  • It is responsible for memory storage and retrieval.

  • It enables social skills.

Cellular Composition of the Brain

  • Neurons: These are the primary functional units of the brain. Their roles include:

    • Responding to stimuli.

    • Conducting electrical impulses.

    • Releasing neurotransmitters.

  • Synaptic Transmission Process: The communication between neurons follows a specific pathway:

    • Presynaptic neuron: The neuron sending the signal.

    • Synapse: The junction or gap between neurons.

    • Postsynaptic neuron: The neuron receiving the signal.

  • Neurotransmitter Destruction: After a signal is transmitted, neurotransmitters must be removed to prevent overstimulation. This occurs via:

    • Enzymes: Chemicals that break down the neurotransmitter.

    • Reuptake: The process where the presynaptic neuron reabsorbs the neurotransmitter.

Organization of the Brain

  • Brainstem: Serves as the processing center for sensory information.

  • Hypothalamus: Manages basic drives and serves as a crucial link between thought and emotion and the function of internal organs.

  • Core: This region regulates internal organs and vital functions.

  • Cerebellum:

    • Regulates skeletal muscle activity.

    • Maintains equilibrium (balance).

  • Cerebrum: Responsible for higher-order functions including:

    • Mental activities.

    • A conscious sense of being.

    • Emotional status.

    • Memory.

    • Control of skeletal muscles and movement.

    • Language and communication.

Visualizing the Brain

  • Electroencephalography (EEG\text{EEG}): A technique used to record electrical activity of the brain.

  • Computed Tomography (CT\text{CT}): An imaging technique used to visualize anatomical structures.

  • Magnetic Resonance Imaging (MRI\text{MRI}): Uses magnetic fields to produce detailed images of brain structure.

  • Functional Magnetic Resonance Imaging (fMRI\text{fMRI}): Measures brain activity by detecting changes associated with blood flow.

  • Positron Emission Tomography (PET\text{PET}): An imaging test that helps reveal how tissues and organs are functioning.

  • Single Photon Emission Computed Tomography (SPECT\text{SPECT}): A nuclear imaging test that uses radioactive substance and a special camera to create 3D pictures to show how organs work.

Disturbances of Mental Function

  • Genetics: Genetic factors play a significant role in the development of mental function disturbances.

  • Neurotransmitters: Imbalances or issues with the following neurotransmitters are associated with mental function disturbances:

    • Norepinephrine

    • Serotonin

    • Dopamine

    • Glutamate

    • γ-Aminobutyric acid\gamma\text{-Aminobutyric acid} (GABA\text{GABA})

    • Neuropeptides

    • Acetylcholine

Action of Psychotropic Medications

  • Pharmacodynamics: This field examines what drugs do to the body and how they do it. It encompasses drug action and drug responses.

  • Pharmacokinetics: This field examines the movement of a drug through the body, defined by the following four processes:

    • Absorption

    • Distribution

    • Metabolism

    • Excretion

  • Pharmacogenetics: This field studies the effects of genetic variation on individual drug responses.

Drug Agonism and Antagonism

  • Agonists:

    • These substances mimic the effects of neurotransmitters naturally found in the human brain.

    • They bind to and stimulate the neurotransmitter's receptor.

  • Antagonists:

    • These substances block neurotransmitters from binding to their receptors.

    • They obstruct the action of the neurotransmitter.

Audience Response Questions

  • Question: Which neuroimaging technique would reveal problems in the anatomical structure of the brain but not problems in function?

    • A. CT

    • B. PET

    • C. SPECT

    • D. None of the above.

  • Answer: A. CT (Computed Tomography\text{Computed Tomography}) is designed to reveal anatomical structure, whereas techniques like PET and SPECT are used to evaluate brain function and metabolism.