Gpos

Gram Positive Bacteria AGR 329

Gram Positive Cocci

  • Key Points:

    • Comparison of Staphylococcus vs Streptococcus

    • Use of Sheep Blood Agar for hemolysis testing

Gram Positive Cocci Staphylococcus species

Macroscopic Appearance

  • On Sheep Blood Agar (SBA):

    • Appearance: white/cream, smooth, butter-like, round

Microscopic Appearance

  • Gram Stain: cocci in grape-like clusters

Metabolic Properties

  • Oxygen Respiration: facultative anaerobe

  • Catalase: positive

  • Oxidase: negative

  • Hemolysis: varies on species

  • Motility: non-mobile

Clinical Importance

  • Zoonotic: MRSA (Methicillin Resistant Staphylococcus aureus)

  • Common Commensal: skin and mucous membranes

  • Diseases:

    • Pyogenic/Suppurative infections (pus-forming) in various species

    • Specific conditions in dogs/cats: conjunctivitis, ear infections, skin infections, uterine infections, bladder infections

    • Mastitis in ruminants and horses, trauma-induced abscesses in horses

    • Bumblefoot in poultry

Gram Positive Cocci Staphylococcus aureus

Characteristics

  • Associated with MRSA and antibiotic resistance (oxacillin, penicillin, amoxicillin)

Diseases Associated

  • Botryomycosis: chronic granulomatous lesions in various animals

  • Scirrhous Cord: enlargement of spermatic cord in castrated horses

  • Bumblefoot: in poultry

  • Omphalitis: bacterial infection in feet of poultry and guinea pigs

  • Symptoms: suppurative wounds, septicemia, pyogenic urinary tract infections (UTI), pyoderma in dogs/horses, lameness and bacteremia in lambs

Gram Positive Cocci Staphylococcus hyicus

  • Commonly infects swine

  • Clinical Disease: exudative epidermitis (greasy pig disease)

    • Symptoms: sebaceous secretions, anorexia, depression, arthritis

Gram Positive Cocci Staphylococcus pseudintermedius

  • Found in dogs and cats

  • Infections: pyoderma, endometritis, cystitis, otitis externa

Staphylococcus -> Micrococcus

  • Nine species, biochemically different

    • Aerobic: oxidase positive, catalase positive

    • Staphylococci resistant to bacitracin, while Micrococcus is not

Gram Positive Cocci Streptococcus sp.

Macroscopic Appearance

  • Appearance: mucoid, round, smooth

Microscopic Appearance

  • Gram Stain: medium cocci in chains, can also appear as singles or pairs

Metabolic Properties

  • Oxygen Respiration: facultative anaerobe/aerobic

  • Catalase: negative

  • Oxidase: negative

  • Hemolysis: differentiates Streptococcus species

    • Beta: pathogenic

  • Tests: CAMP test for recognizing Staphylococcus agalactiae

  • Groups of Strep:

    1. Streptococcus

    2. Enterococcus

    3. Peptoniphilus (mostly anaerobic, not commonly seen)

Gram Positive Cocci Streptococcus species

  • Streptococcus pyogenes: human strep throat

  • Streptococcus agalactiae: bovine contagious mastitis

  • Streptococcus equi: equine strangles

  • Streptococcus zooepidemicus: genital infections in horses, mastitis in cattle, septicemia in swine

  • Streptococcus bovis: lactic acidosis in ruminants

  • Streptococcus suis: meningitis, septicemia, pneumonia, arthritis in swine

  • Streptococcus porcinus: causes jowl abscess/cervical lymphadenitis in swine

  • Streptococcus pneumoniae: pneumonia in cavies and humans

Gram Positive Cocci Enterococcus faecalis

  • Naturally found in GI tract of humans and animals, causing UTIs

  • Appearance: cocci in pairs, chains, facultative anaerobe

  • Pathogenicity: pathogenic in urinary or wound infections, resistant to antibiotics

Review Questions

  • Differentiating Staphylococcus vs Streptococcus: Catalase test

  • Staphylococcus under microscope: grape-like clusters

  • Streptococcus under microscope: chains

Gram Positive Rods

Gram Positive Rods Actinomyces

Macroscopic Appearance

  • Gram Stain: branching rods resembling fungi

Metabolic Properties

  • Oxygen: microaerophilic/anaerobic

  • Catalase: negative

  • Oxidase: negative

  • Hemolysis: gamma

  • Motility: non-motile

  • Normal Flora: opportunistic pathogens

Clinical Relevance

  • Species Examples:

    • Actinomyces viscosus & Actinomyces hordevulneris: associated with puncture wounds in dogs

    • Actinomyces suis: causes mastitis, cystitis, pyelonephritis in sows

    • Actinomyces bovis: causes lumpy jaw in cattle due to wounds in the oral mucosa

Gram Positive Rods Bacillus

Macroscopic Appearance

  • Gram Stain: large rods in chains or pairs, with a medusa head appearance

Metabolic Properties

  • Oxygen: facultative anaerobe/aerobe

  • Catalase: positive

  • Oxidase: positive

  • Hemolysis: beta or gamma

  • Motility: motile

  • Spore forming: capable of endospore formation

Clinical Relevance

  • Bacillus anthracis: bioterrorism agent associated with anthrax

    • Transmission: inhalation, ingestion, wounds, direct contact

    • Symptoms: respiratory failure, septicemia, often fatal

    • Recommendations: cremation or deep lime burial; necropsy should not be performed (no rigor mortis)

  • Bacillus cereus: foodborne illness in humans, gangrenous bovine mastitis, abortion in cows and ewes

Gram Positive Rods Listeria monocytogenes

Macroscopic Appearance

  • Gram Stain: short chains, medium clear/white, round

Metabolic Properties

  • Oxygen: facultative anaerobe

  • Catalase: positive

  • Oxidase: negative

  • Hemolysis: beta

  • Motility: motile at 20 °C

Clinical Relevance

  • Causes Listeriosis: meningitis, encephalitis, uterine infections, abortions, stillbirths

  • Sources: soil, feces, food

  • Two Forms:

    1. Neural: circling disease in ruminants

    2. Visceral: affects monogastric species with sepsis

Gram Positive Rods Corynebacterium

Macroscopic Appearance

  • Gram Stain: small pleomorphic rods/club-shaped

Metabolic Properties

  • Oxygen: facultative anaerobe/aerobe

  • Catalase: positive

  • Oxidase: negative

  • Hemolysis: weak beta

  • Motility: non-motile

Clinical Relevance

  • Species Examples:

    • Corynebacterium diptheriae: human diphtheria

    • Corynebacterium renale: opportunistic in the lower urinary tract

    • Corynebacterium pseudotuberculosis: causes caseous lymphadenitis in small ruminants, often seen in distinct palisades under the microscope

Gram Positive Rods Dermatophilus congolensis

Macroscopic Appearance

  • Gram Stain: branching filamentous rods resembling train tracks

Metabolic Properties

  • Oxygen: aerobe

  • Catalase: positive

  • Oxidase: negative

  • Hemolysis: beta

  • Motility: through zoospores

Clinical Relevance

  • Diseases: Lumpy Wool or Strawberry Foot Rot in sheep, often spreading in rain and wet conditions

Gram Positive Rods Erysipelothrix rhusiopathiae

Macroscopic Appearance

  • Gram Stain: small short rods, gray/white

Metabolic Properties

  • Oxygen: facultative anaerobe

  • Catalase: negative

  • Oxidase: negative

  • Hemolysis: alpha

  • Motility: non-motile

Clinical Relevance

  • Causes Erysipelas, affecting swine, turkeys, and humans, characterized by skin lesions, fever, and joint issues

Review Questions

  • Identify causative agents for specific conditions (e.g., lumpy jaw, anthrax, listeriosis, etc.)

Acid Fast Rods

Definition

  • Acid Fastness: Bacteria resistant to decolorization by acids during staining

Examples

  • Bacillus: Rhodococcus equi, Mycobacterium sp., Nocardia sp.

Acid Fast – Gram Positive Rhodococcus equi

Macroscopic Appearance

  • Microscopic: coccobacillus, mucoid colonies with gray/white coloration

Metabolic Properties

  • Oxygen: aerobic

  • Catalase: positive

  • Oxidase: negative

  • Hemolysis: gamma

  • Motility: non-motile

Clinical Relevance

  • Causes Foal Pneumonia: transmitted via manure and nasal discharge; at risk foals under 6 months

Acid Fast – Gram Positive Mycobacterium sp.

Macroscopic Appearance

  • Gram Stain: medium rods, small yellow/cream round colonies

Metabolic Properties

  • Oxygen: aerobic

  • Catalase: positive

  • Oxidase: negative

  • Hemolysis: varies by species

  • Motility: non-motile

Clinical Relevance

  • Causes granulomas; notable zoonotic species include Mycobacterium tuberculosis (TB), Mycobacterium bovis (bovine TB), and Mycobacterium leprae (leprosy)

Acid Fast – Gram Positive Nocardia asteroides

Macroscopic Appearance

  • Gram Stain: branching rods, pleomorphic, small yellow colonies

Metabolic Properties

  • Oxygen: aerobic

  • Catalase: positive

  • Oxidase: positive

  • Hemolysis: gamma

Clinical Relevance

  • Infects dogs, cattle, swine, sheep; known for causing lesions in thoracic cavity and skin

Review Questions

  • Identify causative agents for various bacterial infections (e.g., foal pneumonia, tuberculosis, Johne's disease, leprosy).