Biomedical

DRUG THERAPIES : USING STIMULANTS TO TREAT ADHD

biomedical therapies : treatments designed to reduce psychological disorder by influencing the action of the central nervous system

  • typically involve the use of medications but also include direct methods of brain intervention including electroconvulsive therapy, transcranial magnetic stimulation, and psychosurgery

DRUG THERAPIES

  • if there is a proper balance of chemicals then the persons mental health will be acceptable

  • psychological disorder will result if there is a chemical imbalance

  • the most frequently used biological treatments provide the patient with medication that influences the production and reuptake of neurotransmitters in the central nervous system

  • the use of drugs is rapidly increasing

  • drug therapy is now the most common approach to treatment of most psychological disorders

  • psychological drug therapies are not specific, they dont change particular behaviors or thought processes and they dont resolve the disorder

  • the best drug combination for the individual patient is usually found through trial and error

In summary : biomedical therapies include any treatments that affect actions of the central nervous system

USING STIMULANTS TO TREAT ADHD

  • adhd is frequently treated with biomedical therapy and cognitive behavior therapy

  • the most commonly prescribed drugs for ADHD are psychostimulants including : Ritalin, adderall, and Dexedrine

  • short acting forms of the drugs are taken as pills and last from 4 to 12 hours

  • some of the drugs are available in long acting forms ( skin patches) and last up to 12 hours

  • stimulants improve the major symptoms of ADHD including inattention, impulsivity, and hyperactivity

  • the effects of the drugs wear off quickly

  • the best drug and dosage varies from child to child

  • when large doses of stimulants are taken, they increase activity, but in smaller doses the same stimulants improve attention and decrease motor activity

  • the most common side effects of psychostimulants in children include increased appetite, weight loss, sleeping problems, and irritability as the effect of the medication wears off

  • stimulant medications may be associated with a slightly reduced growth rate in children, but growth isn’t permanently affected

DRUG THERAPIES : ANTIDEPRESSANT MEDICATIONS

antidepressant medications : drugs designed to improve moods

  • they are effective for patients who suffer from depression,, anxiety, phobias, and obsessive compulsive disorders

  • they work by influencing the production and reuptake of neurotransmitters that relate to emotion including : serotonin, norepinephrine, and dopamine

  • the amount of the neurotransmitters in the central nervous system is increased through the action of the drugs, the person often experiences less depression

  • the original antidepressants were the tricyclic antidepressants which were Tofranil and Elavil. and the monamine oxidase inhibitors Nardil and Parnate

  • those medications worked by increasing the amount of serotonin norepinephrine and dopamine at the synapses but they also had severe side effects including an increse in blood pressure and the need to follow a specific diet

  • the antidepressants most prescribed today are the selective serotonin reuptake inhibitors which are Prozac, Paxil, and Zoloft

  • they are designed to selectively block the reuptake of serotonin at the synapse, leaving more serotonin available in the central nervous system

  • they are safer and have fewer side effects than the tricyclic’s

  • SSRI’s are effective, but the patients taking them often suffer side effects such as : dry mouth, constipation, blurred vision, headache, agitation, drowsiness, or reduction in sexual enjoyment

  • there is a warning on ssri’s from the FDA

  • doctors are more selective about prescribing ssris to teens

  • the effects of antidepressants may take weeks or even months to develop

  • doctors work with each patient to determine which medications are most effective and may change medications to find the best fit

  • other types of antidepressants may be used instead of or with ssri’s

  • these medications work by blocking the reuptake of neurotransmitters including serotonin, norepinephrine, and dopamine. these medications may be Effexor and Wellbutrin

  • patients suffering from bipolar disorder are not helped by antidepressants

  • people with bipolar disorders are primarily treated with mood stabilizers such as lithium

DRUG THERAPIES : ANTIANXIETY AND ANTIPSYCHOTIC MEDICATIONS

anti anxiety medications : drugs that help relieve fear or anxiety

  • they work by increasing the action of the neurotransmitter GABA

  • the increased level of GABA helps inhibit the action of the sympathetic division of the autonomic nervous system, creating a calming experience

  • the most common class of antianxiety medications is benzodiazepines

  • benzodiazepines are tranquilizers

  • these drugs include Ativan, Valium, and Xanax

  • they act within a few minutes to treat mild anxiety disorders but also have major side effects

  • the drugs are addictive

  • the side effects are : drowsiness, dizziness, and unpleasant withdrawal symptoms

  • the drugs are very dangerous when mixed with alcohol

ANTIPSYCHOTIC MEDICATIONS

  • previous to the mid 20th century, individuals with schizophrenia were put in asylums because of their symptoms

  • in the 1950s, it was found that chlorpromazine could reduce many of the symptoms of schizophrenia

  • another name for an sntipsychotic is neuroleptic

antipsychotic drugs : drugs that treat the symptoms of schizophrenia and related psychotic disorders

  • there are many antispychotics such as : Thorazine, Haldol, Clozaril, Risperdal, and Zyprexa

  • some of the drugs treat the positive symptoms, and some treat both the positive, negative, and coognitive symptoms

  • the discovery os chlorpromazine has been described as the single greatest advance in psychiatric care bacuse it has dramatically improved the prognosis of patients in psychiatric hospitals worldwide

  • using antipsychotic medication has allowed hundreds of thousands of people to move out of asylums into households or community mental health centers and live near normal lives

  • antipsychotics reduce the positive symptoms of schizophrenia by reducing the transmission of dopamine at the synapses in the limbic system and improve the negative symptoms by influencing levels of serotonin

  • antipsychotics have some negaitve side effects such as : restlessness, muscle spasms, dizziness, and blurred vision

  • their long term use can cause permanent neurological damage

tardive dyskinesia : uncontrollable muscle movements, usually in the mouth are

  • newer antipsychotics treat more symptoms with fewer side effects than older medications do

DIRECT BRAIN INTERVENTION THERAPIES

  • in cases of severe disorder it may be desirable to directly influence brain activity through electrical activation of the brain or through brain surgery

electroconvulsive therapy : a medical procedure designed to alleviate psychological disorder in which electric currents are passed through the brain, deliberately triggering a brief seizure

  • ECT has been used since the 1930s to treat severe depression

  • when it was first developed, it involved strapping the pateint to a table before the electricity was administered.

  • the patient was knocked out by the shock, went into severe convulsions, and woke up later without memory of what happened

  • ECT is used only in the most severe cases when all other treatments have failed

  • NOW, the patient is given muscle relaxants and a general anesthesia, precisely calculated electrical currents are used to achieve the most benefit with fewest possible risks

  • ECT is very effective

  • about 80% of people who undergo three sessions of ECT report dramatic relief

  • ECT reduces suicidal thoughts

  • the positive effects of ect do not always last

  • over one half of patients who undergo the procedure relapse within one year

  • ECT may cause short term memory loss or cognitive impairment

transcranial magnetic stimulation : a medical procedure designed to reduce psychological disorder that uses a pulsing magnetic coil to electrically stimulate the brain

  • TMS works by activating neural circuits in the prefrontal cortex causing an elevation of mood

  • Tms can be performed without sedation, does not cause seizures or memory loss, and may be effective as ECT

  • TMS has also been used to treat Parkinsons and Schizophrenia

psychosurgery : surgery that removes or destroys brain tissue in the hope of improving disorder

  • psychosurgery is reserved for the most severe cases

  • the most well known psychosurgery is the prefrontal lobotomy

  • developed in 1935 by Egas Moniz

  • developed in order to treat severe phobias and anxiety

  • the procedure destroys the connections between the prefrontal cortex and the rest of the brain

  • the procedure left many patients in worse condition than before

  • the most notable failure was Rosemary Kennedy

  • there are very few centers that conduct psychosurgery

  • the ability to more accurately image and localize brain structures using modern neuroimaging techniques suggests that new, more accurate, and more beneficial developments in psychosurgery may soon be available

In summary :

  • psychosurgery is a procedure that removes or destroys brain tissue that is used hardly ever

  • TMS is a procedure where a magnetic coil electrically stimulates the brain that is used to treat severe depression and schizophrenia

  • ECT is a procedure where a brief seizure is induced by electric currents that is used to treat severe depression