Parasympathetic pathway

Overview of the Parasympathetic Nervous System

  • The parasympathetic nervous system is primarily active during rest and digest activities.
  • It is also referred to as the cranial sacral division of the autonomic nervous system.

Structure and Origin

  • The parasympathetic nervous system arises from the brain stem nuclei.
    • A nucleus is defined as a collection of cell bodies located in the central nervous system (CNS).
    • Key control centers located in the brain stem include:
    • Cardiovascular function
    • Vasomotor tone: the regulation of blood vessel constriction or relaxation
    • Respiratory centers
    • Overall, these centers regulate many automatic functions through the autonomic nervous system.

Pathway of Neurons

  • Parasympathetic nervous system pathways consist of two neurons:
    • First Order Neuron: Originates from brain stem nuclei and travels through cranial nerves.
    • Typically represented in purple in textbooks.
    • First order neurons leave through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus).
    • Known as preganglionic neurons because they synapse close to the target organ.
    • Second Order Neuron: Known as postganglionic neurons, synapse with the first order neurons at specific ganglia before innervating target organs.
    • Preganglionic cells are also referred to as presynaptic cells, while postganglionic cells are referred to as postsynaptic cells.

Neuron Characteristics

  • First order neurons are myelinated type B fibers, which are important for faster conduction along the axon.
  • The length of the pregaglionic neuron is typically long to reach the target organs.
  • The synapse between the preganglionic and postganglionic neurons occurs close to the target organ, in nearby ganglia.
    • The approach of comparing these ganglia to stardust helps visualize the arrangement of ganglia in relation to organs.

Synapse and Neurotransmission

  • The synaptic transmission involves the following:
    • The presynaptic neuron communicates with the postsynaptic neuron by releasing neurotransmitters at the synapse.
    • Postsynaptic neurons have specific receptors that bind to these neurotransmitters.
  • After synapse, the postganglionic neuron (or second order neuron) innervates the target organ directly.
    • These neurons can be referred to interchangeably as postganglionic neurons or, less commonly, ganglionic neurons.
    • Postganglionic neurons are typically unmyelinated and of shorter length. They are classified as type C fibers.

Functional Implications

  • The function of the parasympathetic nervous system is primarily motor, controlling smooth muscle, cardiac muscle, and glandular secretion.
  • An example of this involvement is the pancreas, where postganglionic neurons stimulate cells to release digestive juices in the duodenum during digestion.
  • Each neuron will relay impulses and signals necessary for the proper function of organs during rest and digestive activities.