Layers of the hippocampus

They are the layers of the hippocampus (hippocampus proper / Cornu Ammonis)

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Correct, exam-perfect statement

Stratum oriens, stratum pyramidale, stratum radiatum, and stratum moleculare are layers of the hippocampus proper (Cornu Ammonis).


Breakdown of the layers (deep → superficial) 🧠

  1. Stratum oriens

    • Contains basal dendrites of pyramidal cells

    • Interneurons and axons

    • Lies closest to the alveus

  2. Stratum pyramidale

    • Contains pyramidal neuron cell bodies

    • Principal output neurons of the hippocampus

    • Gives rise to fibres forming the alveus → fimbria → fornix

  3. Stratum radiatum

    • Contains apical dendrites of pyramidal cells

    • Receives synaptic input (e.g. Schaffer collaterals)

  4. Stratum moleculare

    • Most superficial layer

    • Rich in synapses and distal dendrites

    • Receives cortical input (via entorhinal cortex)


High-yield note (often tested)

  • The hippocampus is archicortex3-layered cortex

  • These layers represent subdivisions of those 3 basic layers


One-line oral exam answer

Stratum oriens, pyramidale, radiatum, and moleculare are layers of the hippocampus proper (Cornu Ammonis).

If you want, I can also:

  • Compare hippocampus vs dentate gyrus layers

  • Link layers to memory circuits

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