Hydrophobic clustering and LDFs

Hydrophobic means water fearing

• Cannot interact with water or other polar molecules

• Connor form hydrogen bond or ionic bond forces

• Mostly non polar covalent bonds

• Hydrophobic effect: no polar molecules avoid contact with polar molecules

  • Hydrophobic clustering

  • Biological systems are aqueous

London dispersion forces:very weak attraction between transient opposite partial charges

• very weak force

• Transient force

• Need many interactions to generate apprieciable

• Molecules must be close together

• Hydrophobic molecule affected by hydrophobic effect

Summary

• very weak compared to covalent bonds

• Most relevant for hydrophobic molecules

• Type of covalent bond determines the kinds of non Ava lent interactions that can occur

  • Molecules with mostly polar covalent bonds are hydrophilic

    • can form hydrogen bonds with water

    • Can interact with other polar molecules,including ions

  • Molecules with mostly no polar covalent bonds are hydrophobic

    • Cannot form hydrogen bonds with water or other polar molecules including ions