PSC 4215 - Exam 2 - PLP Plasma Proteins

Front:
Effect of increased plasma protein binding on drug distribution?
Back:
↓ Volume of distribution — more drug stays in plasma

Front:
T/F: Both free and bound drugs can exert effects.
Back:
False — only free drugs are active

Front:
What is fraction unbound?
Back:
[Unbound] ÷ [Total drug]

Front:
Drug is 90% unbound — where is it likely found?
Back:
Tissue — higher Vd, likely tissue-bound

Front:
Warfarin is 0.5% unbound — where is it mostly located?
Back:
Plasma — low Vd, bound to albumin

Front:
T/F: Unbound drug increases overdose risk.
Back:
True — free drug is active

Front:
If all drug is albumin-bound, where does it stay?
Back:
Vascular compartment

Front:
When can plasma proteins cross into tissues?
Back:
During inflammation — ↑ vascular permeability

Front:
Which drugs bind albumin vs. glycoproteins?
Back:
Acidic = albumin; Basic = glycoproteins/lipoproteins

Front:
Effect of protein binding on CT vs. effect curve?
Back:
No CT effect; ↓ intensity, ↑ duration in effect curve

Front:
How does protein binding affect drug onset and duration?
Back:
↓ Onset, ↑ Duration

Front:
T/F: Inactive drugs don't bind plasma proteins.
Back:
False — they bind but exert no effect

Front:
Effect of nephrotic syndrome on albumin-bound drugs?
Back:
Loss of albumin & drug → ↓ effect

Front:
What happens when one drug displaces another from albumin?
Back:
↑ Free drug → effect or faster elimination

Front:
T/F: α1-acid glycoprotein binds fewer drugs than albumin.
Back:
True — easier to saturate

Front:
What kind of drugs bind lipoproteins?
Back:
Basic, lipophilic drugs

Front:
Increased α1-acid glycoprotein → effect on basic drugs?
Back:
↑ Binding → ↓ effect

Front:
Relationship between plasma protein binding and free drug?
Back:
Inverse

Front:
T/F: Plasma conc.–time curve includes both bound and unbound drug.
Back:
True — but mostly bound drug is measured

Front:
Why do low-binding drugs have steeper negative CT slopes?
Back:
More unbound drug → faster elimination

Front:
T/F: High protein binding → more effect and elimination.
Back:
False — drug is sequestered, less effect

Front:
What maintains balance between bound and unbound drug?
Back:
Tissue demand — pulls drug off protein as needed

Front:
T/F: A fast-acting drug is either unbound or lipophilic.
Back:
True — reaches target quickly

Front:
How should you dose a highly protein-bound drug in low-albumin states?
Back:
Lower dose — ↑ free drug, ↑ risk of toxicity