Uremic bleeding solved with dialysis, normal platelets/PT/PTT

Abruptio placentae –. DIC via tissue factor

CKD → high NO → platelet dysfunction, normal coag/platelet counts

Vit C def → impaired collagen → normal PT/PTT/bleeding time, keratosis, coiled hair

Cystic fibrosis → Vit K def → coag factors 2,7,9,10

DIC → decreased platelets, coag factors, and fibrinogen, protein C/S, high D-dimer

TTP = low ADAMTS13 = uncleaved vWF, high LDH, normal PT/PTT

heat stroke → ischemia/necrosis + procoagulants (tissue factor = extrinsic cascade)→ DIC = increased fibrinolysis, thrombin production, & plasmin generation, PT/PTT, D dimers

HITT = heparin induced thrombocytopenia & thrombosis → decreased platelets &IgG again heparin/PF4 complexes

• Fc of antibodies binds platelets → prothrombotic

Platelet factor 4 released from alpha granules of platelets and binds heparin to inactivate

Multiple Myeloma = replicated in bone marrow → osteolytic lesions, replace marrow with plasma cells/plasmablasts

Protein C def → warfarin induced skin necrosis

Nephrotic syndrome = hypercoagulable state due to low antithrombin III

Tumor lysis syndrome →hyperuricemia →crystals in collecting ducts due to low urine pH

Elderly = low bone marrow mass, high bone marrow fat

Direct factor Xa inhibitors → high PT/PTT but normal thrombin time

Antiphospholipid antibody syndrome = SLE, long PTT, thrombosis, recurrent miscarriage

Severe aortic stenosis → acquired vQF deficiency due to shear stress

TTP = thrombocytopenia, microangiopathic hemolytic anemia, renal insufficiency, neurologic symptoms, fever