Insulin deficiency leads to ketoacidosis.
Invariably fatal before insulin discovery.
Therapeutic focus on:
Treating and preventing diabetic ketoacidosis.
Preventing long-term vascular complications.
Insulin resistance with a relative lack of insulin leads to hyperglycemia.
Symptoms include (P-UD-B):
Polyuria (excessive urination)
Polydipsia (excessive thirst)
Blurred vision
Major risk factor for atheromatous disease.
Increasing in affluent and developing countries.
Represents a major public health challenge.
Importance of addressing risk factors distinct from blood glucose, especially hypertension.
Types of insulin and oral hypoglycemic agents.