Brain
Spinal cord
Cranial nerves I and II
Cranial nerves III to XII
Spinal nerves
Neurons: Primary functional unit
Excitability
Conductivity
Influence
Glial cells: Support, nourish, and protect neurons.
Nerve impulse: Initiation of neuronal message, generating action potential.
Synapse: Structural/functional junction where nerve impulse transmits between neurons.
Neurotransmitters: Chemicals affecting impulse transmission across the synapse.
Excitatory
Inhibitory
Spinal cord
Brain
Gray matter
Cerebrum: Right and left hemispheres
White matter
Brainstem: Midbrain, pons, and medulla
Cerebellum: Posterior cranial fossa below the occipital lobe
Ascending tracts
Descending tracts
Reflex arc
Upper motor neurons
Originate in the cerebral cortex and project downward.
Influence skeletal muscle tone (spasticity).
Lower motor neurons
Final common pathway for descending motor tracts to influence skeletal muscle.
Spinal nerves
Series of spinal segments without visible boundaries.
Dorsal (afferent) pair: Sensory nerve fibers/roots.
Ventral (efferent) pair: Motor fibers/roots.
Cranial nerves
12 paired nerves exiting the cranial cavity.
Autonomic Nervous System (ANS)
Sympathetic: Activates "fight or flight" response.
Parasympathetic: Conserves and restores energy; localized and discrete regions.
Physiological barrier between capillaries and brain tissue. Protects brain from harmful agents, allows nutrient entry.
Medication entry into CNS from bloodstream.
Meninges
Skull
Vertebral Column
CNS
PNS
Subjective data
Characteristics of present illness.
Birth history, TBI, stroke, degenerative disease.
Medications.
Surgery or other treatments.
Functional health patterns.
Objective data
Physical examination.
Mental status: alert/oriented; thought process; mood and affect.
Assessment: person, place, time, and situation.
Documentation: A & O x4 (alert and oriented to person, place, time, and situation).
Cranial nerve function
Olfactory (CN I)—smell.
Optic nerve (CN II)- visual fields; visual acuity.
Oculomotor (CN III), trochlear (CN IV), and abducens (CN VI).
Motor function: gait and station
Strength: Push and pull against resistance
Pronator drift: Sensitive to vasospasm or edema in one cerebral hemisphere
Close eyes and hold out arms with palms up for 30 seconds
Sensory function: Sensation to light touch.
Extinction: Simultaneously touching both sides of the body symmetrically.
Normal: both are perceived.
Abnormal: stimulus perceived on only one side.
Pain.
Temperature: Assess only if response to deep pain is abnormal.
Position sense (proprioception): Romberg test.
Cerebellar function: Balance and coordination.
Reflexes: Measure response on a 0 – 5 scale.
0 = absent reflex
1 = weak response, seen only with reinforcement
2 = normal response
3 = brisk response
4 = hyperreflexia with non-sustained clonus
5 = hyperreflexia with sustained clonus
Diagnostic testing
Cerebrospinal fluid analysis
Lumbar puncture (LP)
Contraindications
Pre-procedure preparation
Post-procedure monitoring
PET scan
Single-photon emission computed tomography (SPECT)
Myelogram
Electrographic studies
Electroencephalography (EEG)
Electromyography (EMG)
Electroneurography (nerve conduction studies)
Ultrasound
Carotid artery duplex scan
Transcranial doppler
Biopsies