Timing of Adverse Effects in Relation to Duration of Therapy

Timing of Adverse Effects in Relation to Duration of Therapy

1. Importance of Timing

   • Critical in clinical and epidemiologic evaluation of adverse drug effects.

2. Example

   • Angioedema associated with angiotensin-converting enzyme inhibitors is more common early in therapy.

3. Data Collection Requirements

   • Gather information on the timing of adverse events relating to:

     • Last exposure to the drug.

     • Duration of therapy.