11/08 Synaptic plasticity & addiction/ substance use disorder

Normal fxn of VTA fire to reward cues and can cause LTP and LTD

• reward circuit helps use

drugs basically highlacked he system

What happens when DA increase in concentration in the nucleus ascumbuns

• Typical amount the synapse in this circuit makes it more responsive

paper one: giving concacine to mice: another study gave them coke for only 24hrs dont get potentionation and get a decrease, this is during the early withdrawl period

• a single injection of coke is not enough to get this coke induced synaptic trans

back to altered D1 and D2 functions