WEEK 4 HUMAN ENERGY
Human Energy
HSCI 4662
Measures of Energy
Energy forms:
Mechanical
Chemical
Heat
Electrical
Light
Nuclear
For sport purposes, mechanical, chemical, and heat energy are most important.
Energy Sources
Sun (solar energy)
Animals (chemical energy):
Carbohydrates
Fats
Protein
Plants (chemical energy):
Carbohydrates
Fats
Protein
Humans (chemical energy):
Carbohydrates
Fats
Protein
ATP-PCr
Human Energy Types
Mechanical energy: Capacity to do metabolic work.
Chemical energy: Storage form of energy.
Heat energy: Product of metabolism.
Measuring Work, Physical Activity, and Energy Expenditure
Work and power:
Work = force x distance
Power = work/time
Measurement systems:
English
Metric
International (SI)
Energy Measurement Systems
Terms in English, metric, and international systems:
Mass: slug, kilogram (kg), kilogram (kg)
Distance: foot (ft), meter (m), meter (m)
Time: second (s), second (s), second (s)
Force: pound (lb), newton (N), newton (N)
Work: foot-pound (ft-lb), kilogram-meter (kgm), Joule (J)
Power: horsepower (hp), watt (W), watt (W)
Work and Power Measurement
Interrelationships between work measurement systems:
Weight:
1 kilogram = 2.2 pounds
1 kilogram = 1,000 grams
454 grams = 1 pound
1 pound = 16 ounces
1 ounce = 28.4 grams
3.5 ounces = 100 grams
1 newton = 0.102 kg
Distance:
1 meter = 3.28 feet
1 meter = 1.09 yards
1 foot = 0.30 meter
1,000 meters = 1 kilometer
1 kilometer = 0.6215 mile
1 mile = 1.61 kilometers
1 inch = 2.54 centimeters
1 centimeter = 0.39 Inch
Work:
1 kgm = 7.23 foot-pounds
1 kgm = 9.8 joules
1 foot-pound = 0.138 kgm
1 foot-pound = 1.35 Joules
1 joule = 1 newton meter
1 kilojoule = 1,000 Joules
1 megajoule = 1,000,000 joules
1 joule = 0.102 kgm
1 joule = 0.736 foot-pound
1 kilojoule = 102 kgm
Power:
1 watt = 1 joule per second
1 watt = 6.12 kgm per minute
1 watt = 0.0013 horsepower
1 horsepower = 550 foot-pounds per second
1 horsepower = 33,000 foot-pounds per minute
1 horsepower = 745.8 watts
Measurement of Work and Physical Activity
Ergometer to measure work output:
Cycle
Arm
Devices to measure physical activity:
Pedometer
Accelerometer
Intelligent Device for Energy Expenditure and Activity
Global Positioning Systems
Measurement of Energy Expenditure
Measurement of work is not the same as measurement of energy expenditure.
Isometric muscle contraction: no work produced.
Calorimetry measures energy expenditure:
Direct calorimetry
Indirect calorimetry
Direct Calorimetry
Involves measuring heat production in a chamber with insulation, a thermometer, an air space, a wire to ignite food, and water.
Indirect Calorimetry
Laboratory conditions: Measurement of oxygen uptake and carbon dioxide production.
Real-life conditions: Doubly labeled water technique with stable isotopes of hydrogen and oxygen ingested, followed by analysis of urine and blood for hydrogen and oxygen to measure carbon dioxide fluctuation.
Commonly Used Measure of Energy
In the United States, the Calorie.
In most of the world, the joule.
1 gram calorie will increase the temperature of 1 gram of water 1 degree Celsius.
1000 gram calories = 1 kilocalorie.
Kilocalorie (Calorie or ,C,) is the most common measure of energy.
The Calorie
Some approximations of 1 Calorie (kilocalorie):
foot-pounds
kilogram-meters
kilojoules (kJ) or joules
milliliters of oxygen (approximately)
Calories in macronutrients and alcohol.
Calories in Macronutrients and Alcohol
: One gram of carbohydrate
: One gram of fat
: One gram of protein
: One gram of alcohol
Atwater Factors
Energy values in foods:
: One gram of carbohydrate
: One gram of fat
: One gram of protein
: One gram of alcohol
Calories in Food
The Calories in 8 ounces of orange juice provides enough energy for the average male to run a mile.
Human Energy Systems
Energy systems for muscular activity in the human body are designed to produce energy for work at varying rates.
How Energy is Stored in the Body
Adenosinetriphosphate (ATP)
Phosphocreatine (PCr)
Carbohydrate
Fat
Protein
Energy for Metabolic Activity
ATP is the immediate source of energy for metabolic activity, including muscle contraction.
PCr can regenerate ATP rapidly.
Both ATP and PCr are in very short supply.
Carbohydrate, fat, and protein can be metabolized to produce ATP and PCr but takes more time.
Energy Pathways
Protein
Carbohydrate (Glucose)
Fat (Fatty acids)
Acetyl CoA
Krebs cycle
ATP
Electron transport chain
Major Energy Stores
Major energy stores in the human body with approximate total caloric value:
ATP:
Major storage form: Tissues
Total body Calories: 4.2
Total body kilojoules: 16.8
Distance covered: 17.5 yards
PCr:
Major storage form: Tissues
Total body Calories: 16.8
Total body kilojoules: 70
Distance covered: 70 yards
Carbohydrate:
Serum glucose:
Total body Calories: 20
Total body kilojoules: 88
Distance covered: 350 yards
Liver glycogen:
Total body Calories: 400
Total body kilojoules: 1,680
Distance covered: 4 miles
Muscle glycogen:
Total body Calories: 1,500
Total body kilojoules: 6,300
Distance covered: 15 miles
Fat:
Serum-free fatty acids:
Total body Calories: 7
Total body kilojoules: 29.2
Distance covered: 123 yards
Serum triglycerides:
Total body Calories: 75
Total body kilojoules: 315
Distance covered: 0.75 mile
Muscle triglycerides:
Total body Calories: 2,500
Total body kilojoules: 10,500
Distance covered: 25 miles
Adipose tissue triglycerides:
Total body Calories: 80,000
Total body kilojoules: 336,000
Distance covered: 800 miles
Protein:
Muscle protein:
Total body Calories: 30,000
Total body kilojoules: 126,000
Distance covered: 300 miles
Human Energy Systems for Runners
Anaerobic power (ATP-PCr): 60-200 meters (6-20 seconds)
Anaerobic capacity (anaerobic glycolysis; lactic acid): 400-800 meters (43-103 seconds)
Aerobic power (aerobic glycolysis): 5,000-10,000 meters (12-26 minutes)
Aerobic capacity (aerobic lipolysis): 42.2-100 kilometers (125-360 minutes)
The ATP-PCr Energy System
Adenosine Triphosphate
Adenosine with 3 high energy phosphate bonds
Energy is released when a phosphate bond is broken for muscle contraction
The ATP-PCr Energy System
Phosphocreatine (PCr)
Creatine with a high-energy phosphate bond.
PCr donates its phosphate to ADP to regenerate ATP.
The Lactic Acid Energy System (Anaerobic Glycolysis)
Glycolysis converts carbohydrate (glycogen) to lactic acid, producing ATP.
Energy Pathways of Carbohydrate, Fat, and Protein
Glycolysis: Glucose to Pyruvate
Takes place in the cytosol of the cell.
Enzymes in the cytosol participate at the following steps:
Hexokinase
Phosphohexose isomerase
Phosphofructokinase
Aldolase
Phosphotriose isomerase
Glyceraldehyde-3-phosphate dehydrogenase
Phosphoglycerate kinase
Phosphoglycerate mutase
Enolase
Pyruvate kinase
Lactate dehydrogenase is used to recycle NADH + H+ back to NAD (anaerobic glycolysis).
Presents a phosphate group.
Addition of phosphorus to glucose by ATP
Glucose activates the 6-carbon glucose molecule.
The later metabolism of fructose 6-phosphate to fructose 1-6 bisphosphate uses another ATP.
The 6-carbon molecule, fructose 1,6-bisphosphate, is split into two 3-carbon molecules: one is glyceraldehyde 3-phosphate, and the other is eventually converted into that product as well.
The conversion of each pyruvate to lactate allows a cell to recycle NADH + H+ back to NAD. This then allows glycolysis to continue, as NAD is needed. This latter pathway occurs primarily in only a few types of cells, such as red blood cells, and under high-in anaerobic conditions such as very intense exercise.
Metabolism of each 1,3-bisphosphoglycerate to 3-phosphoglycerate results in the synthesis of ATP.
Metabolism of each phosphoenolpyruvate to pyruvate results in the synthesis of another ATP.
Pyruvate can undergo further metabolism to enter the citric acid cycle, which occurs in the mitochondria.
The Oxygen Energy System
Aerobic glycolysis: Oxidation of glycogen or glucose.
Aerobic lipolysis: Oxidation of fatty acids (beta oxidation).
Aerobic proteolysis (limited energy production): Oxidation of glucogenic or ketogenic amino acids.
Respiration and Circulation
Lungs take in oxygen from the atmosphere.
Central circulation: Heart pumps oxygen-enriched blood.
Peripheral circulation: Arteries carry oxygen-rich blood to muscle tissues.
Metabolism: Muscle cells take in and use oxygen to produce energy (ATP) from carbohydrates and fats.
Muscle Metabolism
Muscle protein (Amino acids)
Muscle glycogen (Glucose)
Muscle triglycerides (FFA)
Krebs cycle occurs
and are produced
Electron transport (ETS)
ATP produced
Energy Production Overview
Liver (Glucose)
Adipose tissue (Triglycerides)
Active muscle (Amino acids, Glucose, Free fatty acids, Oxygen, Muscle glycogen)
Lungs (Oxygen)
Blood transports Glucose, Free fatty acids, Amino acids, and Oxygen.
Muscle: Acetyl CoA, Krebs cycle, Electron transport system produces , , and ATP
ATP is used for muscle contraction
Phosphocreatine (PCr) provides energy for muscle contraction
Transition Reaction
Pyruvate is first metabolized in a transition reaction to acetyl-CoA.
It is acetyl-CoA that actually enters the citric acid cycle. In the process, NADH + H+ is produced and is lost.
Acetyl CoA may also be generated from fatty acids and amino acids to serve as a source of energy.
Conversion of pyruvate to acetyl CoA by PDH
The Citric Acid Cycle (Krebs Cycle)
The citric acid cycle begins when an acetyl group carried by CoA combines with a C4 oxaloacetate molecule to form citrate.
Oxaloacetate is re-formed during the final step of the cycle.
Twice over, substrates are oxidized, NAD+ is reduced to NADH + H+ and is released.
ATP eventually is made as energy is released from the breakdown of an intermediate in the cycle.
Once again an intermediate in the cycle is oxidized, and NAD+ is reduced to NADH + H+.
Again an intermediate in the cycle is oxidized, but this time FAD is reduced to FADH2.
Electron Transport System
Electrons move from one molecular complex to the other, hydrogen ions () are pumped from the mitochondrial matrix into the intermembrane space (steps 1-4).
Hydrogen ions flow down a concentration gradient from the intermembrane space into the mitochondrial matrix; ATP is then synthesized by the enzyme ATP synthase (step 5).
ATP leaves the mitochondrial matrix by way of a channel protein.
Energy Pathways for Fatty Acids
Triglycerides in adipose tissue are catabolized by hormone-sensitive lipase, with fatty acids released to plasma and binding to albumin; glycerol component is transported to the liver for metabolism.
A receptor at the muscle cell transports the fatty acid into the muscle cell where it is converted into fatty acyl CoA by an enzyme (fatty acyl CoA synthetase).
Fatty acyl CoA is transported into the mitochondria with carnitine as a carrier.
Fatty acyl CoA then undergoes beta-oxidation, splitting off acetyl CoA units for entrance into the Krebs cycle.
Lipoproteins and Lipid Metabolism
Chylomicrons carry absorbed fat to body cells.
VLDL carries fat taken up from the bloodstream by the liver, as well as any fat made by the liver, to body cells.
LDL arises from VLDL and carries mostly cholesterol to cells.
HDL arises from body cells, mostly in the liver and intestine and buds off other lipoproteins. HDL carries cholesterol from cells to other lipoproteins and to the liver for excretion.
Intermediate Density Lipoprotein (IDL)
Nutrients for Human Energy Systems
Water: Involved in hydrolysis.
Vitamins: B vitamins, as coenzymes, are involved in many energy processes.
Minerals: Minerals, as metalloenzymes, are also involved in energy processes; iron is part of hemoglobin to transport oxygen.
Dietary Supplements
Carnitine, coenzyme Q10, and others marketed to athletes
Human Energy Metabolism during Rest
What is metabolism?
Basal Metabolic Rate (BMR): Resting; post-absorptive; Maintain basal metabolism; Only sleeping metabolism is lower.
Basal Energy Expenditure (BEE): BMR extrapolated over 24 hours.
Resting Metabolic Rate (RMR): BMR + small amounts due to prior activity.
Resting Energy Expenditure (REE): RMR extrapolated over 24 hours.
Human Energy Metabolism
What is metabolism?
Thermic Effect of food (TEF): Also known as Dietary Induced Thermogenesis (DIT); Post-meal elevation in RMR due to digestive processes.
Human Energy Metabolism
What is metabolism?
Thermic Effect of Exercise (TEE): Also known as Exercise Metabolic Rate (EMR); Increase in metabolic rate associated with exercise; Metabolic aftereffects of exercise
Total Daily Energy Expenditure (TDEE) = sum of BEE (REE), TEE, and TEF
Human Energy Metabolism
What is metabolism?
Metabolism represents the sum total of all physical and chemical changes that take place within the body.
Anabolic metabolism (anabolism): Constructive processes
Catabolic metabolism (catabolism): Disintegration processes
Metabolism
Total Daily Energy Expenditure (TDEE):
Basal and resting energy expenditure
Thermic effect of food
Thermic effect of exercise
Factors Affecting Energy Expenditure During Rest
Basal metabolism:
Basal metabolic rate (BMR): Energy needed to stay alive when awake; Only sleeping metabolic rate is lower
Basal energy expenditure (BEE): Basal metabolism over 24-hour period
Factors Affecting Energy Expenditure During Rest
Resting metabolism:
Resting metabolic rate (RMR): BMR plus small amounts associated with eating, prior activity; About 10 percent higher than BMR
Resting energy expenditure (REE): Resting metabolism over 24 hour period
Effect of Eating on Metabolic Rate
Metabolic rate is elevated after a meal
Specific dynamic action
Dietary-induced thermogenesis
Thermic effect of food (TEF)
Effect of Eating on Metabolic Rate
TEF is expressed as the % of meal energy content
5-10% for a mixed meal
TEF may be a consideration in some weight-control diets
Estimating Daily Resting Energy Expenditure
Estimate not as accurate as BMR test
May be useful for weight control programs
Other methods include effects of daily activity
Estimating Daily Resting Energy Expenditure
Simple methods to estimate RMR
1 Calorie/kilogram body weight per hour
Various formulae
Estimation of RMR (Males)
Equations for Males (based on age in years):
3-9:
10-17:
18-29:
30-60:
> 60:
Example: 154-lb male, age 20
154 lbs/2.2 = 70 kg
Estimation of RMR (Females)
Equations for Females (based on age in years):
3-9:
10-17:
18-29:
30-60:
>60:
Example: 121-lb female, age 20
121 lbs/2.2 = 55 kg
RMR Range of Values
To get a range of values, add or subtract a normal 10-percent variation to the RMR estimate.
Male example: 10 percent of 1,750 = 175 Calories
Normal range = 1,575-1,925 Calories/day
Female example: 10 percent of 1,304 = 130 Calories
Normal range = 1,174-1,434 Calories/day
Genetic Factors Affecting REE
Age: Infancy through adulthood
Gender: Females REE about 10-15% lower
Natural hormonal activity
Body surface area
Genetically lean versus stout
Body Composition and REE
Body composition: Muscle versus fat
Losing body weight, both fat and muscle, lowers REE
Maintaining normal body weight while reducing body fat and increasing muscle mass may raise REE
Decline in REE with aging may be associated with loss of muscle mass
Environmental Factors Influencing REE
Exposure to cold weather: Thermogenesis
Exposure to warm or hot weather: Sweating and cardiovascular demands
Exposure to altitude: Increased ventilation
Environmental Factors Influencing REE
Cigarette smoking: Nicotine
Caffeine: One study found increases of 10 percent
Energy Sources Used During Rest
The oxygen energy system prevails during rest
About 60 percent of energy from fat
About 40 percent of energy from carbohydrate
Small amount of energy from protein
Energy Sources Used During Rest
The diet may affect the energy source during rest
Eating a diet rich in carbohydrate or fat will, respectively, increase energy production from carbohydrate and fat
Human Energy Metabolism during Exercise
Exercise stresses most body systems
Neuromuscular system determines the energy system to be used during exercise
Muscle Influence on Energy Production During Exercise
Skeletal muscle fiber (cell) with Sarcolemma and Nucleus
Skeletal muscle (Epimysium, Perimysium, Connective tissue)
Bundle (a group of muscle fibers)
Myofibril myofilaments (Sarcomere)
Actin and myosin
Muscle Fiber Types
Three main types of muscle fibers
Type I: Slow twitch red fiber; Slow oxidative (SO)
Type IIa: Fast twitch red fiber; Fast oxidative-glycolytic (FOG)
Type IIb (IIx): Fast twitch white fiber; Fast glycolytic (FG)
Muscle Fiber Types Characteristics
Type I
Twitch speed: Slow
Color: Red
Size (diameter): Small
Fatigability: Slow
Force production: Low
Oxidative processes: Highest
Mitochondria: Highest
Myoglobin: Highest
Blood flow: Highest
Triglyceride use: Highest
Glycogen use: Lowest
Phosphocreatine levels: Lowest
Energy for sports: Aerobic capacity; aerobic power
Type IIa
Twitch speed: Faster
Color: Red
Size (diameter): Medium
Fatigability: Moderate
Force production: High
Oxidative processes: Moderate
Mitochondria: Moderate
Myoglobin: Moderate
Blood flow: Moderate
Triglyceride use: Moderate
Glycogen use: Moderate
Phosphocreatine levels: Higher
Energy for sports: Aerobic power; anaerobic capacity
Type IIb (IIx)
Twitch speed: Fastest
Color: White
Size (diameter): Large
Fatigability: Fast
Force production: Highest
Oxidative processes: Lowest
Mitochondria: Low
Myoglobin: Low
Blood flow: Lowest
Triglyceride use: Lowest
Glycogen use: Highest
Phosphocreatine levels: Higher
Energy for sports: Anaerobic power; anaerobic capacity
Muscular Exercise and Metabolic Rate
All physical activity increases the metabolic rate
Activities of daily living (ADL)
NonExercise Activity Thermogenesis (NEAT)
Planned exercise activity
Exercise metabolic rate (EMR)
Thermic effect of exercise (TEE)
Exercise Intensity and Metabolic Rate
Caloric expenditure per minute at different intensity levels relative to resting metabolic rate:
Resting metabolic rate: 1.0
Sitting and writing: 2.0
Walking at 2 mph: 3.3
Walking at 3 mph: 4.2
Running at 5 mph: 9.4
Running at 10 mph: 18.8
Running at 15 mph: 29.3
Running at 20 mph: 38.7
Maximal power weightlift: >90.0
Measuring Exercise Intensity
Actual work output: Ergometer (watts)
Physiological cost of the activity:
ATP-PCr energy system
Muscle biopsy
Computerized imaging procedures
Measuring Exercise Intensity
Lactic acid energy system
Onset of blood lactic acid (OBLA); steady-state threshold
Oxygen energy system
Oxygen uptake; maximal oxygen uptake ()
Example
3.6 L (3600 ml) = 60 kg body weight, : 60 ml /kg/minute
4.0 L (4000 ml) = 60 kg body weight, : 66 ml /kg/minute
Training
Training increases
Relationship between and Steady state threshold
Steady state occurs at 50% of
Stead state threshold occurs at 80% of
Expressing Energy Expenditure of Exercise Metabolism
Calories
Kilojoules
Oxygen uptake
METS (One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml per kg body weight x min.)
Multiples of the RMR
Energy Expenditure Constants
1 MET = 3.5 ml /kg body weight/minute
Heat to raise 1 kg of water 1°
1 Calorie = 4.2 kilojoules (kJ)
Energy Expenditure
1 MET resting oxygen uptake
3.5 ml x 70 kg = 245 ml per minute
1 Liter Oxygen = 5 Calories (kilocalories)
1 Liter Oxygen = 1000 milliliters
245/1000 = 0.245 liter oxygen per minute @ 1 MET
0.245 L x 5 Calories/L = 1.225 Calories/minute
Exercise Energy Equivalencies
Liters of oxygen/minute | Calories/minute | Kilojoules/minute | METS | |
|---|---|---|---|---|
Rest | .25 | 1.25 | 5 | 1 |
Slow walk (2 mph) | .5-.75 | 2.5-3.75 | 10-15 | 2-3 |
Fast walk (5 mph) | 1.5-1.75 | 7.5-8.75 | 30-35 | 6-7 |
Run (8 mph) | 2.5-3.0 | 12.5-15.0 | 50-60 | 10-12 |
Energy Interconversions Scenario
A sedentary, untrained, 80-kg male is running 12 minutes per mile (5 mph) and is consuming 3.36 liters of oxygen per minute. Assume the following:
1 Calorie (C) = 4 Kilojoules (kJ)
1 liter oxygen = 5 Calories
1 MET = 3.5 ml oxygen/kilogram/minute
Energy Interconversions
Assume the following:
1 Calorie (C) = 4 Kilojoules (kJ)
1 liter oxygen = 5 Calories
1 MET = 3.5 ml oxygen/kilogram/minute
Calculate the following:
Calories per minute he is using
Kilojoules per minute he is using
MET level at which he is exercising
Metabolic Rate During Exercise
Oxygen consumption is precise, but not very practical
Other physiological measures
Heart rate
Respiratory rate
Physiological Response vs Exercise Intensity
Low Intensity Exercise
Low Oxygen consumption
Low Heart Rate
Low Respiration
High Intensity Exercise
Maximal Oxygen consumption
Maximal Heart Rate
Maximal Respiration
Determining the Energy Cost of Exercise
Example with body weight in kilograms and pounds, and energy expenditure for different activities like skiing, soccer, squash, and swimming.
Activities to Increase Energy Expenditure
Activities involving large muscle groups
Walking
Running
Swimming
Cycling
Group Exercise
Activities to Increase Energy Expenditure
Activities involving large muscle groups
Home exercise equipment
Resistance or weight training (lower than aerobic)
Passive and occupational energy expenditure
Intensity and duration
Classification of Physical Activities Based on Energy Expenditure
Light, mild aerobic exercise (<5 Calories/min)
Archery
Badminton, social
Baseball
Bicycling