Withdrawal

03//26/25

  • A lot of variance

    • what drug is/ was/were used

    • How frequently was it used

    • What quatinty of the drug was used

    • Changes in symptoms across time durring abstance

  • Homeostatic compensation

    • Durring chronic use we see changes in how the brain functions to adapt to changes in neurotranmiter systransmitter systems that result from the drug use

      • Ex

    • New basline levels of activity

      • dopamine

      • gaba

      • opioid

    • Brain tires to keep homeostaisis when you take a drug reguarly, the homeostsis starts to effect the drug, so your brain needs these drugs to maintain homeostaisis

    • Homeostatic responses to the drug effects (pleasure, Pain)

    • I

  • HPA axis

    • Changes in how hypothalimus tiriggers this system @ basline leads to more stress during withdrawls

    • leads to hightened stress response Blocking cortictropin-releasing factor (CRF) that they hypothalamus uses to activate the pitutary glans

  • Sypmotoms

    • phiscal

      • Tremors

      • Gi tract

    • emotional

      • irrablity

      • restlessness

    • Psychological

      • suicidality

      • memory (korsakoff’s) due to B1 loss- alcholol related mainly (alchol gets rid of B1 in system)

  • Timeline

    • short term

      • immediate (on the time scale of hours)

    • Long term

      • months

    • onset of symtoms related to drug half life

      • how quickly the drug is metabloized

  • specific drugs

    • i

  • acute withdrawl

    • drives drug seeking

    • changes in addcition circut encorgeing drug seeking

    • power point

    • cocaine immidate increase in matabloism

  • Protracted withdrawl

    • long term chronic withdrawl symptoms

      • not an apa dignoses

    • it takes months for the brain circuts to rewire- if they ever do

    • anhedoins- alchol withdrawl can lead to loss of pleasure for a year

    • I

    • changes in activity across frequcany bands

      • changes

      • just like with intoxication

  • Back and fourth between excitation and inhibition

    • all the time

    • the rate @ which we flip flop back and foruth switches

    • Zoneing out is slow back and fourth of waves

    • Attentive sate is higher back and fourth (arousal, directed attention)

    • shallow or deep wave (shallow is unsycned) (large wave is sycned)

    • In withdrawl there are changes in this activity to higher amplitde, higher force (higher levels of arousal)