UMD NSFC100
NSFC 100
Course Objectives
To learn the basic concepts of nutrition and ot understand how nutritional needs change over the lifespan
To learn how the body digests, absorbs, and utilizes the nutrients we obtain from food
To learn the role of food and nutrition in the promotion of health, the prevention of chronic diseases, and the impact on our environment
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January 24, 2024
Nutrition: the science of food and the nutrients they contain
Scientific Method:
Formulate hypothesis: best guess to explain previous observations
Test hypothesis: use different study designs
Evaluate study results: get conclusion
Compare to original hypothesis: proven (become theory) or not proven (revise hypothesis)
Types of studies:
Case (individual)
Epidemiological studies (populations) : correlation of nutrition and health outcomes
Laboratory (pre-clinical) studies : mechanism-based study using experimental animals
Intervention (clinical) studies : experimental vs control (placebo) group
Food labeling:
Provides information about nutrients in food
Help to make the “best” choice & can be used to decide what is the “healthier” choice
Nutrition labeling and Education Act (NLEA) 1990 - US Federal Law signed in 1990 gave the FDA the authority over nutrition labeling and claim on most foods
January 31, 2024
% Daily Value:
Indicates how much of a specific nutrient one serving of food contains compared to daily nutrient recommendations based on a 2,000 calorie diet
5-10-20 rule:
Below 5% is considered low or poor source
10-19% is considered a good source
Above 20% is considered high, or excellent source
Types of Claims:
Nutrient content claims (level of nutrients & terms: free, low, reduced, etc)
Calorie free: less than or equal to 5 calories per serving
Low calorie: less than or equal to 40 calories per serving
Reduced calorie: at least 25% lower in calories than regular food
Sodium free
Fat free: less than 0.5g of fat per serving
Low fat: up to 3 grams of fat per serving
Reduced, less, fewer: at least 25% less of fat than a reference food
Health Claims: approved by FDA based on scientific evidence
Examples follow: calcium → osteoporosis, sodium → hypertension, etc
Structure/Function Claims (need additional science evidence and FDA approval or state that “FDA has not evaluated the claim”
January 29, 2024
What causes hunger?
Hypothalamus
Regulate hunger by communicating between brain & body
Regulate the release and uptake of chemicals
Satiety center in brain
Processes nerve signals throughout the body
Hormones/Brain Chemicals
Ghrelin from stomach, a major physiological hunger signal
Leptin from adipose (fat) tissue, suppresses the desire to eat
Neuropeptide Y from hypothalamus
A type of neurotransmitter
Send message to the brain when the body need nourishment
Composition of Meals
Dietary fiber and water are more filling
High protein vs high carbohydrate
“Want to”
Psycho-social response
Food as reward/coping device
What influences food choices
Natural environment (climate, rainfall, etc)
Technology (farming practice, food storage, food distribution, advertising)
Income, demand, population size
Food desert
Are with limited access to affordable and nutritious food, particularly an area composed of predominantly low income neighborhoods
Food Insecurity: inability of an individual or household toa ford and to access a health and adequate diet
Hypertension & dietary factors
Excessive body weight, abdominal fat : calorie in > calorie out
High sodium intake
Excessive alcohol consumption
Inadequate potassium intake
Nutrient → components of food used for the body’s functioning
Nutrition → the study of the nutrients in food and in the body
Classes of Nutrients
Proteins
4 cal/g
Main structural material in the body
Component of blood cells, enzymes, and immune factors
Made up of amino acids which are bonded together
Carbohydrates
4 cal/g
Simple sugars: monosaccharides and disaccharides
Complex carbohydrates: glycogen, starch, and fiber
Lipids
Energy yielding 9 cal/g
Fats & oils : both plant and animal sources
Animal fats (solid at room temperature) - limited can raise blood cholesterol contributing to cardiovascular disease
Plant oils (liquid at room temperature)
Vitamins
Enable chemical reactions to occur in the body
fat-soluble–A, D, E, and K
Water soluble–B vitamins and C
Cooking destroys water soluble more readily than fat soluble
Provides no calories/energy
Minerals
Numerous functions in the body
Water
Alcohol - 7 cal/g
Macro vs Micro nutrients
Macronutrients : proteins, carbohydrates, lipids
Micronutrients : vitamins and minerals
Calorie - amount of heat energy needed to raise the temperature of one kilogram of water by 1 C
Kilocalorie = calorie
Recommended Macronutrient Proportion by Age
Nutrient density
Food is nutrient-dense when it provides a large amount of a nutrient for a relatively small amount of calories compared to other foods
Nutrient dense food are rich in vitamins, minerals, other beneficial substances
Few calorie, low in fat, minimized added salt, fat, refined starches, etc
Vegetables, fruits, whole-grains, low-fat dairy, legumes, nutes
Consuming nutrient-dense food is the best way to control calories
Characteristics of “nutritious diet”
Adequacy: nutrients, fiber, energy in amounts sufficient to maintain health
Moderation: certain food constituents need to be consumed with limitation
Variety: a wide selection of foods are included
Balance: all food groups are represented
Calorie control: control of energy intake
January 31, 2024
Obesity: body mass index (BMI) of 30 or higher
Body Mass Index (BMI): kg/m^2
Limitation of BMI (athletes)--therefore obesity refers to an excess of body fat
Obesity ratings have increases upwards of 20% from 1990 until today
73% of US adults are overweight
Diet Evaluation
Dietary reference intakes (DRI’s)
Umbrella term for:
RDA (recommended dietary allowances) → average daily dietary nutrient intake sufficient to meet the nutrient requirement of nearly all healthy individuals in the group
To set the RDA scientists need to estimate the average need for a group
Add 30-50% to cover needs to nearly all in that group
Set high to allow for some variation over time to cover most of the population
EER (estimated energy requirement)
Estimates energy (kcal) intake needed to match the energy use of an average person in a specific life stage
EER needs to be specific, taking into account age, gender, height, weight, and physical activity
Serves as a starting point for estimating calorie need
EAR (estimated average requirement) → average daily nutrient intake estimated to meet the requirement of half the healthy individuals
Limited in number due to few human studies
For health professionals to develop RDA’s and plan diets for groups of individuals
AI (adequate intake)
Recommended average daily intake based on observed, experimentally determined estimates of nutrient intake by a group of healthy people
Assumed to be adequate
Used when RDA cannot be determined
Tolerable Upper Intake (UL)
Total intake from food, fortified food, and supplements should not exceed the amount, or adverse health effects may result
Not a recommended amount
Dietary guidelines for Americans
Updated every 5 years
Purpose is to provide science-based advice for ages 2 & above
Includes those at increased risk of chronic disease
Goals: follow a healthy pattern at every life stage (1), customized nutrient-dense food & beverage choices (2), focus on meeting food group needs (3), and limit foods and beverages higher in added sugars, saturated fats, and sodium, and limit alcoholic beverages (4)
There are 3 Key Dietary Principles that can help people achieve the Dietary Guidelines
Meet nutritional needs primarily from food and beverages
Choose a variety of options from each food group
Pay attention to portion size
Healthy eating pattern limits: saturated, trans fats, added sugars and sodium
Consume less than 10% of calories a day from added sugars and saturated fats
Consume less than 2,300 milligrams of sodium per day
Foods to increase
Make half your plate fruits & vegetables
Make at least half your grains whole grains
Switch to fat-free or low-fat (1% milk)
Balancing calories → enjoy your food but eat less & avoid oversized proportions
Foods to reduce → compare sodium in foods (soup, bread, frozen meals)
DRINK WATER
Macronutrient Breakdown of Diet
CHO 45-60% of kcal
Protein 10-35% of kcal
Total fat 20-35% of kcal
10% saturated fat
Less than 300 mg cholesterol
Serving vs Portion
Serving → a unit of measure
Position → amount of food actually served or consumed
How much fruit for me 2 cups & 2.5 cups of vegetables, 3 cups of “dairy & 5.5 oz for age group
Book Notes (ch. 03):
Nutrient density = (amount of nutrient per serving)/(amount of calories per serving)
Oranges are more nutrient dense than orange juice
Choose a variety of options from each food group
Important because no singular food will meet all someone's nutrient needs
Select foods from each of the five major food groups: fruits, vegetables, grains, protein, and dairy
All forms of food can be nutrient dense (though this is dependant upon other factors such as processing)
Portion size: the amount of food consumed in one eating
Serving size: on labels are used to help someone choose an appropriate portion size
Energy density is a measurement that best describes the calorie content of a food → (amount of energy/kcal per serving)/(weight or volume of serving)
Energy dense but empty calories include sugar-sweetened beverages, cookies, fried foods, and even fat-free snacks
Low energy density includes fruits, vegetables, and any food that incorporates lots of water during cooking, such as oatmeal
Low energy dense foods are better as they tend to contain less sugars, unhealthy fats, and are low in fiber
People consume fewer calories in a meal if most of the food choices are low in energy density, compared with foods high in energy density–an eating pattern low in energy density can aid in losing and managing weight
Foods with lots of water and fiber are good as they contribute fewer calories but maintain fullness
Concept check 2.1:
List three benefits or eating plenty of fruits and vegetables
F&V are nutrient dense (a lot of nutrients for the amount of calories it provides), have low energy density (not many calories for each portion), and will maintain fullness for longer periods of time because of the above qualities
Describe a change that could be made to improve the nutrient density of typical food choices
Reduce added sugar intake, and rely on natural sources such as fruits
Digestion = the process by which food is broken down into absorbable nutrients (mechanical and chemical)
Absorption = the uptake of nutrients by the cells of the small intestine for transport into either the blood or the lymph
Metabolism = how your processes it after that
Gastrointestinal tract the digestive tract
Digestive system includes the tract and the accessory organs
Mouth: mastication=chewing=teeth crushing and food mixes with saliva
Tongue pushes food back to be swallowed
Food passes over tongue into the pharynx (shared by airways and GI tract)
Epiglottis covers the airway
Large intestine = colon
February 5, 2024
The Cell - basic unit of life
Genes – determine cell function
Nucleus – “control center” send directions to the cell to grow, mature, divide or die (contains DNA)
Plasma membrane – regulates what enters/leaves cell
Cytoplasm – fluid and organelles between nucleus and outer membrane
Mitochondria - power plant, supply ATP, have their own genetic material (seperate from the DNA)
Endoplasmic reticulum (ER) - membranous channels involved in the synthesis, modification and transport of cellular materials (works closet with Golgi apparatus & ribosomes)
Golgi apparatus - packaging center (packages molecules processed by ER to be transported out of the cell)
Ribosomes – process the cell’s genetic instructions to create proteins (protein synthesis)
Lysosomes – housekeeper & recycling center of the cell (digest foreign bacteria, rid toxic substances, digest excess organelles, recycle work-out cell, etc)
Tissue - group of cells performing a specialized function (epithelial, connective, muscular, nervous)
Organ – group of tissues performing a specialized function
Different body systems
Integumentary system (skin, hair, nails, sweat glands)
Provides covering for the body and maintains body temperature
Cardiovascular system (heart, blood vessels, blood)
Transports nutrients and oxygen around the body
Review capillaries
Lymphatic system (lymph vessels, lymph nodes, organs including spleen and tonsils)
Returns fluids to blood & involved in lipid absorption
Defense against pathogens
Plasma = fluid in the blood
Extracellular fluid = outside cells in tissues
Intracellular fluid = inside cells
Skeletal & Muscular Systems (bones, joint, ligaments, cartilage)
Provides support and protection
Body can move
Nervous system (central & peripheral)
Brain, spinal cord → main control system for the body
Nerves and nerve cell clusters → receive information and send it to the brain
Concerned with sensation, interpretation, integration
Endocrine system (Hypothalamus and glands including pituitary gland, thyroid, adrenal, pancreas, etc)
Secretes hormones that help control body activities such as growth and reproduction
Digestive & Urinary System (mouth, esophagus, stomach, intestines, kidneys, bladder, ducts)
Takes in, breaks down, and absorbs food; then excretes
Excretes waste as urine and regulates body water and salt balance
Regulates acid-base balance of blood
Respiratory System (lungs and respiratory passages: pharynx, larynx, trachea, bronchi)
Takes in O2 and excretes CO2 and other wastes
Nutrients affect ability to carry O2 and protection mechanisms
Reproductive system (gonads & genitals)
Production of offspring
Immune System
Nonspecific defense (innate immune system) vs specific defense (adaptive immune system)
Main cells of the immune system
Lymphocytes and phagocytes
Produce antibodies
February 7, 2024
Digestion = the process by which food is broken down into absorbable nutrients
Absorption = the uptake of nutrients by the cells of the small intestine for transport into either the blood or the lymph
Metabolism = how your body processes it after that
Gastrointestinal (GI) tract = the digestive tract
Mouth → mastication = chewing = teeth crush food into smaller pieces, and food mixes with saliva
Swallowing → food passes over tongue into the pharynx (shared by airways and GI tract)
Epiglottis covers the airway to prevent food from entering lungs
The lump of food is now called a blouse
The bolus passes through the upper esophageal sphincter into the esophagus
Slides down and pass through the lower esophageal sphincter and into the stomach
The Stomach
Stomach = retains the food for a while
Adds lots of digestive juices…bolus is now semi-liquid and call chyme
Slowly released chyme through the pyloric sphincter into the small intestine
Food is churned
Thickest walls and strongest muscles of the whole GI tract
The Small Intestine
Small intestine – 10 feet long
Accepts secretions through the bile duct and pancreatic duct coming from the gallbladder/liver and the pancreas
The Large intestine
Large intestine = colon
Chyme travels through the ileocecal valve to enter the colon
Exit → rectum & anus
Sphincter Contraction : open and close to make sure food is moving in the right direction
Wrong direction or leaks = problems (heartburn…)
Digestive Enzymes
Enzymes = a biological molecule that increases the rate of chemical reactions
Enzymes end in “-ase”
Protease (protein)
Lipase (lipid)
Carbohydrase (carbohydrate)
Sucrase (sucrose)
Digestive Secretions
Mouth : salivary glands
Saliva moistens food for chewing & saliva contains enzymes that start ot break down
Carbs: salivary amylase breaks amylose starch
Triglycerides (lipids/fats) : salivary lipase starts to break down lipids
Mucus and salts also protect the linings of the mouth & esophagus
Stomach : gastric juice
A mixture of water, enzymes, and HCl (low pH)
Carbs: salivary amylase is inactivated by the acid
Fats: salivary lipase is still active in stomach acid
Protein: the acid and pepsin (enzyme) start to break down protein
Intestines: pancreatic juice: enzymes that act on all 3 macronutrients (enters through the pancreatic duct in the small intestine
Bile = emulsifies the chyme
Produces in liver, stored in gallbladder
Enters through the bile duct
Bile neutralizes the stomach acid
Intestinal wall enzymes
Final step of nutrient break-down
Absorption → most nutrient absorption occurs in the small intestine
Surface area of the small intestine is roughly 30 m^2
Colon → water and mineral re-absorption
Bacterial fermentation of some fiber (gut microbiome)
Absorption of fermentation products
Changes pH
Rectum and Anus → stores and regulates elimination of feces
Fiber holds water, regulates bowel activity, and binds cholesterol and some minerals, carrying them out of the body
Excretory Products:
Feces → fiber and other undigested food components
Bile Products
Urine → urea from amino acids
Book Notes (ch. 3):
Common heafutres in human cells:
Membranes, cytoplasm & organelles
Cell (Plasma) Membrane
Not an organelles but holds together the cellular contents and regulates the flow of substances into and out of the cell
Cell to cell communication also cocurs by way of the cell membrane
Phospholipids are a unique type of liid that has a water soluble head and a fat soluble tail
Enzymes regulate chemical reactions
Cytoplasm
The combination of fluid material and organelles within the cell
Mitochondria
Organelles are largely responsible for converting the chemical energy carbohydrates, lipids, proteins, and alcohol from foods and drinks into a form of energy that cells can use
Nucleus
Surronded by double membrane (nuelcear envelope)
Nucleus stores and protects th ecells DNA
DNA is packaged as structures called chromosomes
A segment of DNA on a chromosome that codes for a specific protein is called a gene
Endoplasmic Reiculum
RER (rough) - covered in ribosomes (protien synthesis location)
SER (smooth) - are involved in liid synthesis detoxification of harmful substances and storage of calcium in the cell
Golgi Complex
Packaging site for proteins and lipids produced in the cell
Conisstis of sacs within the cytoplasm where proteins and lips are packaged into secretory vesicles for transport within the cell or secretion from the cell
Lysosomes
Digestive system
Sacs contain enzymes of the digestion of foreign material
Responsible for digesting worn-out or damaged cell components
Peroxisomes
Contain enzymes that detoxify harmful chemicals
To counter the damaging effects of hydrogen peroxide within the cell they contain a protective enzyme called catalase (breaks doen hydrogen peroxide into water and oxygen)
Tissues
Epithelial tissue is composed of cells that cover surfaces both inside and outside the body
Connective tissue supports and protects the body, stores fat, and produces blood cells
Muscle tissue designed for movement
Nervous tissue which is found in the brain and spinal cord
“Only the enzymes from the digestive system are made of protein” help?
Lymphatic system removes foreign substnances from the blood and aids in fat absorbtion VS cardiovascular system that transports nutrients, waste, gases, and hormones through the body
The exchange of nutrients, oxygen, and waste products between the blood and the cells throughout the body occurs across the cells lining the capillaries
Plateles and red blood cells are not present in lymph
Lymph and blood have white blood cells and plasma in common
Roles of the endocrine system: roduce hormons, maintinas water balance, plays a major role in the regulation of metabolism
Amylase is produced by the pancrease and salivary glands
The coordinated muscular contraction that propels food along the gastrointestinal tract is called peristalsis
Digestive system supports the immune system by transporting fats to the immune system
Compared to the small intestine the large intestine absorbs fewer nutrients and houses more bacteria
Stomach makes dietary minerals soluble, activates digestive enzymes, digests proteins
Imbalance of good and bad microbes in the gut is called gut dysbiosis
Presence of fat in the small intestine causes the release of a hormonal signal that triggers the gallbladder to release bile
Small intestine is a highly folded surface covered with villi
Probiotics: live microorganisms that clonize the large intestine and may provide health benefits
Prebiotics: forms of dieary fiber that are poorly digested by humand but can serve as food for probiotics and in tirn support gut health
February 12, 2024
Carbohydrates
Monosaccharides - simple sugar units: glucose, fructose, galactose
Disaccharides - formed by chemical bonding of 2 monosaccharides
Sucrose: glucose + fructose - also known as simple sugars
Lactose: glucose + galactose - milk products
Maltose: glucose + glucose - from fermentation & alcohol production
Simple vs. Complex CHO
Monosaccharides: single units
Disaccharides: two units
Complex carbohydrates
Polysaccharides: many glucose units
Starch (plant CHO storage)
Glycogen (animal CHO storage)
Fiber (undigestable CHO)
Formation of polysaccharides
Fiber: indigestible starch. The human body cannot break the bonds to digest fiber
Insoluble or nonfermentable fiber are:
Cellulose and hemicellulose
Not fermented by colonic bacteria
Soluble or viscous fiber are:
gum , pectin & mucilage
Fruit, vegetable, rice brain & psyllium seed
DIgestion & absorption of CHO
role : break down starches into monosaccharides, so they can be absorbed
By the time food reaches the large intestine, most of the starches are digested, only fiber remains
Starch and Sugar Digestion
Enzymes made by mouth, pancreas, and small intestine participate in the process of digestion
Digestion starts in the mouth with Salivary amylase:
Breaks starch to shorter saccharides
Prolonged chewing
Food has short duration in mouth
Stomach
Acidic environment stops salivary amylase activity
No further starch digestion
Small intestine
Pancreas releases pancreatic amylase
Acted on by maltase, sucrase, and lactase on luminal surface of intestinal absorptive cells
Monosaccharides are absorbed
Amylase: starch-digesting
Made in salivary glands found in saliva
Made by pancreas: secreted into small intestine
Maltase: acts on maltose
Made by absorptive cells of small intestine
Digests maltose two glucoses
sucraseL acts on sucrose
Made by absorptive cells of the small intestine
Digests lactose to glucose and galactose
Lactose intolerance → results from a lactase deficiency (breaks down lactose into glucose and galactose & activity of lactase is highest after birth
Lactase deficiency → amount of lactase decline in childhood and adolescence & genetics affects your ability to produce lactase
CHO absorption
Glucose and galactose:
Generally follow active absorption process
Requires specific carrier and energy inputs
Fructose: facilitated diffusion & carrier is used, no energy input needed
Galactose and fructose
Liver metabolizes into glucose
Transport metabolism & storage of CHO
Monosaccharides are absorbed from small intestine into capillaries
Main function of glucose: supply cells of the body with energy/calories
Certain tissues use only glucose for energy:
Brain prefers glucose, but can adapt to using ketones over weeks
Red blood cells
Carbohydrates are protein sparing if the diet supplies enough carbohydrate
Prevents ketosis–a high concentration of ketone bodies and related breakdown products in bloodstream and tissues
Regulating Blood Glucose:
After a meal, blood glucose rises
The body takes action to store it (pancreas release insulin to tell body’s cells to take up glucose)
Between meals, blood glucose drops
Pancreas releases the hormone glucagon (blood glucose rises)
You have enough glycogen supply for few hours
If you eat too much carbs: glycogen stores in the liver and muscles are full (immediate energy needs are met) the, metabolism shifts to use more sugar than fat for energy (liver converts excess glucose to fat)
Diabetes:
Diabetes: glucose rises after a meal and remains above normal because insulin is either inadequate or ineffective
High blood glucose can damage many parts of the body : lenses of eye, nerve damage, blood vessel damage & kidney damage
Typex 1: the pancreas fails to produce insulin
Type 2: cells don’t respond adequately to insulin
HypoglycemiaL blood glucose drops below normal values (weak, dizzy, sweating, tremling)
Health effects of High-Fiber Foods
Heart disease: diets rich in whole grains and soluble fibers lower risk for heart disease and stroke
Lower blood pressure & risk of diabetes
Reduce inflammation
Improve blood cholesterol
Recommended intake: total carbs
Total cho: 45-65% of total kcals (FNB)
2000 kcal diet: 900-1300 kcals=225-325g CHO
RDA : 130g
AI 25g for women
AI 38g for men
Lipids!
Functions in the body:
Long term energy stores
Protects organs from physical shock
Thermal insulation (temperature extremes)
Two fatty acids must be supplied by the diet to maintain health
Alpha-linolenic acid
Linoleic acid
Other fatty acids and regulatory compounds can be synthesized from the essential fatty acids
Cholesterol is not an essential nutrient
Lipase: fat-digesting enzyme produced by salivary glands, stomach, & pancreas
Long-chain fatty acids (dietary fats) absorbed into lymphatic system which empties into the bloodstream
In the small intestinal cells, fatty acids are re-formed into triglycerides & packaged as chylomicrons (transport vehicles for dietary lipids
LDL (lousy) = low-density lipoprotein → bad “cholesterol” when it is high the risk of cardiovascular disease increases
HDL (helpful) = high-density lipoprotein → good “cholesterol” when it is high the risk of cardiovascular disease decreases
Lipoprotein: transport vehicle for lipids in the blood
Trans fat intake increase LDL and inflammation
Trans Fat consumption increases risk for cardiovascular disease (partial hydrogenation)
Heart healthy fats: monounsaturated & polyunsaturated
Saturated Fatty Acids: increase blood levels of cholesterol
Long chain → sources include animal fats (lard)
Medium & short chain → butter & coconut oil
Monounsaturated Fatty Acids: decrease blood levels of cholesterol
canola oil
Polyunsaturated Fatty Acids: decrease blood levels of cholesterol
Fish oil
Essential Fatty Acids: omega 3 reduces inflammation responses, blood clotting & plasma triglycerides → cold water fish & soybean oil
Omega 6: regulates blood pressure & increases blood clotting → beef & poultry
Trans fatty acids increase blood cholesterol more than saturated fat (margarine)
Recommendations for fat intake:
Total fat: 20%-35% of kcal from total fat
Saturated fat (limit intake) → less than 10% of kcal saturated fat
No limits on dietary cholesterol
AHA recommended 2 or more servings of fish per week
Dietary patterns that promote cardiovascular health : mediterranean diet & vegetarian diet plan