PHQ - 2 is for depression
questions
if it is positive then we do a PHQ 9
Major depressive disorder
first line
SSRI Sertraline (zoloft)
2 SSRIs that are safe in older adults
zoloft and lexapro
Dangerous in older adults
fluoxetine - long half-life
Paxel (most sedating) 3:29
What SSRI would you avoid with someone who has anxiety?
Prozac - nervousness is a known side effect
In a pediatric patient for whom therapy has not helped, what is the first line for depression
prozac
SNRI - (Duloxetine (Cymbalta), Venlafaxine (Effexor)
DO NOT USE WITH uncontrolled HTN
cause increase in BP due to norepi
Key education
4-6 weeks to start working
after that we can increase dose or check out the underlying conditions
Usually we keep them on these for 6-12 months after symptoms are gone
Sides
GI issues - no need to stop, they will disappear
sexual issues
weight gain
Tricyclic antidepressants - Nortriptyline (pamelor)
not first line
cause
weight gain and ECG changes
NONE IN OLDER ADULTS
Bupropion (Wellbutrin)
Avoid in patients with anxiety and insomnia because it stimulates
can be used for smoking cessation
can be used with SSRI for low libido
Herbal supplements
St john’s wort for depression
Do not take with any SSRI or SNRI due to serotonin syndrome
Signs of Seratonin syndrome
shivering
tachy
agitation
EMERGENCY prompt referral to ED
Anxiety
pneumonic
WATCHERS
First line
SSRI or SNRI
adjunct med
buspar or buspiroe
screening
GAD 2 if score is above 3 then GAD 7
PTSD
Medication and therapy first line
first line
SSRI
Insomnia
first line
education about sleep hygiene
then therapy
then meds
benedryl / melatonin
Ambien but sides are a lot
BOX warning for sleep driving
Bi polar
characterised
extreme mood episodes
mania like bipolar 1 then they get depressed
First line
Lithium
narrow therapeutic range 0.6-1.2
anything at 1.5 or greater is toxic
signs of lithium toxicity
N/V
tremors
hyperactive reflexes
vision changes
What gland to watch
Thyorid cause lithium can lead to hypothyroid
Antipsychotics -
typical or first gen
halodol
Atypical second gen
serequel or zyprexa
Weight gain hyperlipids, hyperglycemia
Most psych meds are liver metabolism with CYP450 enzyme or CYPA4 and CYP2C19
don’t play with digoxin and warfarin