Study Notes on Endogenous and Exogenous Cannabinoids

MS in Medical Cannabis Science and Therapeutics

Course Overview

• Program: Master of Science (MS) in Medical Cannabis Science and Therapeutics

• Institution: University of Maryland, School of Pharmacy

Course Module Information

• Module Title: MCST602: Module 3: Lecture 3

• Lecture Focus: Endogenous vs. Exogenous: How Drugs Work Part III: The Endocannabinoid System

• Instructor: Andy Coop, PhD

  • Position: Professor, Associate Dean for Academic Affairs

Module Objectives

1. Cannabinoid Differentiation:

   • Learn to differentiate between endogenous and exogenous cannabinoids.

Course Level Learning Objectives

• Physiological Functions:

  • Describe the physiological functions of the endocannabinoid system in the human body.

Cannabinoids

Endogenous Cannabinoids

• Definition:

  • Endogenous cannabinoids are compounds that are naturally produced in the body.

• Examples of Endogenous Cannabinoids:

  1. Anandamide

  2. 2-Arachidonoylglycerol

  3. 2-Arachidonyl glyceryl ether

  4. N-Arachidonoyl dopamine

  5. Virodhamine

Exogenous Cannabinoids

• Definition:

  • Exogenous cannabinoids are derived from external sources.

• Example of Exogenous Cannabinoid:

  • THC (Tetrahydrocannabinol):

  • THC is the primary neuroactive constituent of marijuana.

  • Mechanism of Action:

    • THC acts as an agonist at cannabinoid receptors CB1 and CB2, prompting physiological responses.

    • Comparison: Understanding the difference between exogenous THC and endogenous cannabinoids in function and action.

Pharmacological Considerations

FAAH Inhibitors

• Definition:

  • Fatty acid amide hydrolase (FAAH) inhibitors are substances that prevent the breakdown of endogenous cannabinoids, potentially enhancing their effects in the body.