Hormonal Control of Calcium Homeostasis

Hormonal Control of Calcium Homeostasis

• Calcium homeostasis involves dietary intake and calcium storage.
• Key players include osteoblasts and osteoclasts in bone remodeling, formation, mineralization, and resorption.
• Vitamin D plays a crucial role.
• Parathyroid hormone (PTH), calcitonin, and other hormones regulate calcium homeostasis.
• Understanding osteoporosis and other bone diseases is essential.

Calcium Homeostasis

• Calcium homeostasis is a complex equilibrium between:
  • Bone formation/resorption (osteogenesis/osteolysis)
  • Calcium absorption/secretion from kidneys and the gastrointestinal (GI) tract

Cells Involved

• Osteoblasts: Derived from fibroblasts; build the bone matrix and are converted into osteocytes.
• Osteoclasts: Derived from macrophages;