Leukotriene Receptor Antagonists (Leukotriene Modifiers)

Leukotriene Receptor Antagonists (Leukotriene Modifiers)

Overview

  • Oral agents like montelukast are used for mild persistent asthma.

  • Recommended dosing: once daily at bedtime for optimal effect.

Mechanism

  • Leukotriene receptor antagonist: Selective competitive inhibitor of CysLT receptor.

Indications

  • Montelukast

    • Long-term control for patients ≥1 year of age.

    • Can be used with ICS for moderate persistent asthma.

  • Zafirlukast

    • Long-term control for patients ≥7 years of age.

    • May also be combined with ICS for moderate persistent asthma.

Summary

  • Both agents are effective for controlling asthma symptoms and can be dosed at bedtime for better management of nighttime symptoms.