Golgi Transport Models

Golgi Transport Models

Stationary Cisterna Model

• This model explains how molecules move through the Golgi stack (CGN, MGN, TGN).

• Transport between Golgi stacks occurs via vesicles.

• Vesicles bud off from one Golgi compartment and fuse with the next.

  • Vesicles arriving at the CGN from the ER fuse with the CGN.

  • The CGN then forms vesicles that bud off and fuse with the MGN.

  • The MGN, after processing, forms vesicles that fuse with the TGN.

• The Golgi stacks themselves remain stationary; movement is solely vesicle-mediated.

Retrograde Transport

• Retrograde Transport: Movement of molecules in the opposite direction (e.g., from TGN back to CGN).

• Involves vesicles budding off and fusing to an earlier Golgi compartment or the ER.

• Example: If a protein in the TGN is needed in the CGN, a vesicle buds off from the TGN and fuses with the CGN or ER.

• Like anterograde transport, retrograde transport is also vesicle-mediated.R