Kevin McStay's Mayo will be desperate for a first Division 1 victory at the third attempt, while Malachy O'Rourke's Tyrone will be looking to bounce back from a comprehensive defeat by Armagh last time out when the sides meet in Allianz National Football League action.
Tyrone started off well in Round 1, defeating Derry by seven points, but they won't have been happy with their display against Armagh at the Athletic Grounds in Round 2.
There's likely to have been a fair bit of video work done on their speed of transition compared to Armagh, their failure to follow runners and anything else you're having some of. Armagh were vastly superior in almost every area of the game.
It's this inconsistency from one day to the next and within games that has dogged Tyrone in recent years and something Malachy O'Rourke will go after hard.
Where is the game being played?
The game is being played at MacHale Park, Castlebar
What time is throw-in?
Throw in is at 1.45pm
Can I watch the game on TV?
Yes, the game is live on TG4 with coverage beginning at 1.15pm
Is the game being streamed online?
Yes, it is live on the TG4 Player.
Betting Odds?
Mayo: 1/2